Báo cáo khoa học: The mitochondrial permeability transition from in vitro artifact to disease target ppt

... a rate-limiting step in steroid synthesis [159]. The PBR also binds some porphyrins, including protoporphyrin IX, a potent inducer of the PTP [160], and is thought to be involved in transport of porphyrins ... protein located in the outer mitochondrial membrane [153] and was initially identified as a binding site for ben- zodiazepines in tissues that lack 4-aminobutyrate rece...

Ngày tải lên: 30/03/2014, 11:20

... in the table using the ~-expression, and then finding the corresponding element in the model. If the element in the model that was the denotation of the h-expression was not expanded in the ... maintaining the correctness of the denotations of ~-expressions basically involves incorporating the table from the first mechanism into the model. In effe...

Ngày tải lên: 21/02/2014, 20:20

... on the role of this protein in the biogenesis of heme-containing proteins in plants. To gain insight into this process, we decided to study the role of frataxin using the enzyme catalase as a model. ... demonstrated that fra- taxin serves as a potential donor to FC for insertion of iron into the protoporphyrin ring during heme synthe- sis. Knocking down the expression of...

Ngày tải lên: 28/03/2014, 23:20

... decomposing the persulfide into sulfide in the presence of thiols, whereas, in vivo, it involves the transfer of the persulfide-sulfur sulfane to a cysteine residue of a sulfur acceptor protein. In E. ... associated with the protein moiety. The addition of 0.1 mm cyste- ine to the protein sample induced a shift in the major peak in the range 390–420 nm, which indi...

Ngày tải lên: 18/02/2014, 04:20

... of the purified proteins indicated that they contained < 5% contaminating proteins. The concen- trations of proteins used in these studies were determined by spectrophotometric methods using ... of aB-crystallin is target protein-specific In order to investigate the effect of Arg-HCl on the chaperone activity of aB-crystallin, we examined a variety of model target proteins...

Ngày tải lên: 18/02/2014, 16:20

... for their cytotoxic action, and their target RNA is in the cytosol. It has been proposed that the cytosolic RNase inhibitor (cRI) plays a major role in determining the ability of an RNase to be ... to be cytotoxic. However, to interact with cRI RNases must reach the cytosol, and cross intracellular membranes. To investigate the interactions of cytotoxic RNases with mem...

Ngày tải lên: 19/02/2014, 06:20

... N-linked oligosaccharide side-chains are important for the GABA transport activity. 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal ... analysis. To construct the GAT1 ⁄ GFP fusion proteins, HindIII— StuI fragments containing the cDNAs of GAT1 wild type or mutants were cut from the pAlter-1 vector, the...

Ngày tải lên: 19/02/2014, 17:20

... necessary; in this case, it is precisely the end point of the building event that coincides with the beginning of the event of the house being new. In a system using Allen's primitives, the ... Under the interpreta- tion that the cake is warm while John is frosting it, the time span during which the cake is warm must include the time 3:00; however, the s...

Ngày tải lên: 21/02/2014, 20:20

... adjoin- ing (OA) constraint. Whether/3 can be adjoined at the node (labeled by A) in 7 is determined by the SA constraint of the node. In 7 t the nodes contributed by/3 have the same constraints ... associated with the corresponding nodes in/ 3. The remaining nodes in 7 ~ have the constraints of the corresponding nodes in 7. Given p E dom(7), by Ibl(7,p) we r...

Ngày tải lên: 22/02/2014, 10:20

... cytoplasmic DP8 and DP9. The observed decreases in DP9-overexpressing cells of the ECM-interacting molecules discoidin domain receptor 1, a kinase activated by collagen binding, and the MMP inhibitor, ... inhibitors in pathogenic conditions, such as can- cer. To gain a better understanding of the effectiveness and outcomes of therapeutic DP inhibitors, it will be valuable to a...

Ngày tải lên: 06/03/2014, 09:22