Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc

... The Authors Journal compilation ª 2006 FEBS Benzo [a] pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for ... significant weight gain and increased fat mass without detectable changes in food intake. Upon withdrawal of this PAH, the excess weight g...

Ngày tải lên: 30/03/2014, 11:20

... mitochond- rial b-ketoacyl-ACP synthase, bacterial plus plastid b-ketoacyl-ACP synthases I and II, and a domain of human fatty acid synthase, have a Cys-His-His triad and also a completely conserved Lys in ... extracts of this strain are unable to extend radiolabeled acetate (lane 5) in 30 min assays at 42 °C. Addition of wild-type KAS I resulted in syn- thesis of lo...

Ngày tải lên: 19/02/2014, 08:20

... Watanabe,T.,Kobori,K.,Kiyotaka,Miyashita,Fujii,T.,Sakai, H. & Makot, Uchida and Tanaka, H. (1993) Identification of glutamic acid 204 and aspartic acid 200 in chitinase A1 of Bacillus circulans WL-12 as essential residues for chitinase activity. ... which increases in molecular mass and DA resulted in efficient loading and minimization of the release of entrapped...

Ngày tải lên: 19/02/2014, 12:20

... (snowdrop) GNA Man Mana6(Mana3)ManaR Glycine max (soybean) SBA GalNAc GalNAca3Galb6Glc Griffonia simplicifolia I GSA I GalNAc GalNAca3Gal, GalNAca3GalNAcb3Gala4Galb4Glc Griffonia simplicifolia II GSA II ... Gal Galb3GalNAca Canavalia ensiformis (jack bean) Con A Man ⁄ Glc GlcNAcb2Mana6(GlcNAcb2Mana3)Manb4GlcNAc Datura stramonium (thorn apple) DSA GlcNAc (GlcNAc) n , Galb4GlcNAcb6(Galb4GlcNA...

Ngày tải lên: 16/03/2014, 10:20

... it appears that at least three oligomannoside structures may be involved as degradation signal for ERAD (Man8GlcNAc2 and Man6GlcNAc2 for glycoproteins bearing Man9 species and Man4GlcNAc2 for ... Man9 glycans and glycoproteins bearing Man5 glycans can be efficiently degraded. A wide variety of variables can lead to defective synthesis of lipid- linked oligosaccharides and, th...

Ngày tải lên: 16/03/2014, 16:20

... Bose 1 and Ira W. Levin 2 1 Laboratory of Cell Biology, National Heart, Lung, and Blood Institute and 2 Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, ... dynamic parameters derived from intermolecular and intramolecular motions. Band shapes are often analyzed in the context of statistical mechanical theories of irreve...

Ngày tải lên: 17/03/2014, 03:20

... line extract and in sputum Mast cells contain substantial amounts of a variety of proteases, including chymase, tryptase, carboxypepti- dase A3 and dipeptidyl peptidase I (cathepsin C), that participate ... does not cleave P1- Lys containing substrates [24] and, more recently, as a result of a phylogenetic analysis of mammalian CGs [37]. Human chymase also has an Ala res...

Ngày tải lên: 28/03/2014, 22:20

... (Caspase 9) and DYRK1B SmartPool (Dharmacon) comprising four different duplexes: 5¢-GAAAUUGACUCGCUCAUUGrUrU-3¢,5¢-ACACGG AGAUGAAGUACUArUrU-3¢,5¢-GCCAGAGGAUCUA CCAGUArUrU-3¢,5¢-GCACAUCAAUGAGGUAUACr UrU-3¢. ... DYRK 1A (sense strands): 5¢-UAAGGAUGCUUGAUUAUGAdTdT-3¢ (DYRK 1A# 1), 5¢-AAACUCGAAUUCAACCUUAdTdT-3¢ (DYRK 1A# 2). Other siRNAs used were 5¢-CGUACG CGGAAUACUUCGAdTdT-3¢ (Luciferase), 5¢...

Ngày tải lên: 30/03/2014, 02:20

... chain of the human/rat CRH analogue seems to fold to an almost linear tertiary structure with the main features being the high degree of helical character and a small bend along the principal molecular ... meaningful NOE and 32 H-bonds distance limits) and 21 angle constraints. A family of 40 energy-minimized conformers was obtained with average rmsd of 0.39 ± 0.16 A ˚...

Ngày tải lên: 17/03/2014, 10:20

... InsP 6 gradually into InsP 5 , InsP 4 , and the final product – Ins(2,4,6)P 3 and Ins(1,3,5)P 3 – via two alternative pathways [14]. Bacterial BPPs containing two tandemly repeated domains (dual domains) ... can increase the amount of available phosphate by interacting together. Additionally, fusing PhyH-DI to a single-domain phytase appears to be an efficient way to improve the activit...

Ngày tải lên: 14/02/2014, 15:20