Báo cáo khoa học: Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells potx

... FEBS Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells K. Rathinasamy and D. Panda School of Biosciences and Bioengineering, ... the suppression of microtubule dynamics by benomyl was the cause for the loss of tension across the kinetochores and activation...

Ngày tải lên: 30/03/2014, 10:20

... levels, and sLe a expression in cancer cell lines and recombinant clones We also measured the levels of b3Gal-T5 transcript and b1,3Gal-T activity in different cancer cell lines and clones, and compared ... formed in metabolically radiolabelled cells. The main radioactive oligosaccharides formed in BxPC3 cells (j in lower part, and A, B, and C of upper part)...

Ngày tải lên: 19/02/2014, 12:20

... termination, and recy- cling. Initiation is the rate-limiting step [1]. This phase is mediated by initiation factor 1 (IF1), initiation fac- tor 2, and initiation factor 3. IF1 is the smallest of ... substrates for the binding of ribo- somal proteins and maturation factors [13]. Among these structures are double-stranded stems that are composed of terminal flanking sequences of...

Ngày tải lên: 06/03/2014, 00:21

... of ROS production in pancreatic b -cells [6]. Those authors found suppression of high glucose-induced ROS production and decreased glucose-stimulated insulin secretion by DPI in cells of the insulin-producing cell ... USA). Determination of apoptosis occurrence To assess the occurrence of apoptosis in NIT-1 cells, cells were double-stained with Annexin V and...

Ngày tải lên: 06/03/2014, 02:20

... Terao, T. (2001) Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun-dependent signaling pathways. J. ... Terao, T. (2001) Structure and function analysis of urinary trypsin inhibitor (UTI): identification of binding domains and signaling property of UTI by analysis of...

Ngày tải lên: 17/03/2014, 11:20

... mL) and incu- bations continued in fetal bovine serum-free culture medium for 24 h in the presence of ApoA-I ⁄ phosphatidylcholine (100 lgÆmL )1 ). At the times indicated in the text, aliquots of the ... 0.001) (Fig. 1). Inhibition of NF-jB transcrip- tional activity by CRLPs containing trilinolein or triacylglycerol from corn oil was confirmed by mea- suring luciferase activ...

Ngày tải lên: 23/03/2014, 04:20

... levels of the expression of hsps differed depending on the drug. Induction of thermotolerance of cells by IND As IND and NDGA caused hsps to accumulate in mammalian cells, we next examined whether ... is otherwise insufficient. In contrast, IND induces the expression of Hsp70 in human umbilical vein endothelial cells [18] or induces the nuclear localiz ation of H...

Ngày tải lên: 30/03/2014, 15:20

... performance of upper-level residents and other medical staff across a variety of disciplines. We likewise agree that optimizing patient hand- offs, medical education, and trainees’ sense of professionalism ... rapidly increases after 16 hours of sustained wakefulness, a finding reflected in the twofold increase in interns’ attentional failures after they had been working for...

Ngày tải lên: 25/10/2012, 10:45

... bias in the selec- tion of recombination points. It has been suggested that optimal recombination points allow swapping of structural blocks [19], and combination of large pro- tein fragments in ... chimera, recombination preserved the integrity of domain D1 and the very end part of domain D3, two regions that interact precisely in the natural laccase fold (Fig. 5). Becaus...

Ngày tải lên: 18/02/2014, 06:20

... morphology of the strains used in this study. (A) Morphology of deletion strains. The indicated strains were grown in YPD to stationary phase. The cells were then fixed with formaldehyde and examined by ... formation of a mating projection [28]. Furthermore, homologues of oxysterol- binding proteins, a family of proteins that regulate the synthesis and transport of ster...

Ngày tải lên: 18/02/2014, 13:20