Báo cáo khoa học: Leishmania donovani bisubunit topoisomeras

Báo cáo khoa học: Leishmania donovani bisubunit topoisomerase I gene fusion leads to an active enzyme with conserved type IB enzyme function doc

... Leishmania bisubunit topoisomerase I into a single ORF encoding a new monomeric topoisomerase I (LdTOPIL-fus-S). It was found that LdTOPIL-fus-S is active. Gene fusion leads to a signiﬁ- cant modulation ... hetero- dimeric topoisomerase I within the parasite. This un- usual structure of DNA topoisomerase I may provide a missing link in the evolution of type IB...

Ngày tải lên : 30/03/2014, 10:20

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Tài liệu Báo cáo khoa học: Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves ppt

... addition to their roles in myelination, trophic sup- port and axon regeneration, SCs exhibit potential immune functions, similar to the non-myelinating glia of the CNS. SCs can be induced to produce ... Neuroregeneration, Nantong University, Jiangsu, China 2 Department of Microbiology and Immunology, Medical College, Nantong University, Jiangsu, China 3 Department of Surgery, RICH Hospi...

Ngày tải lên : 18/02/2014, 18:20

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Báo cáo khoa học: Leishmania donovani methionine adenosyltransferase Role of cysteine residues in the recombinant enzyme pptx

... describes the molecular cloning and characterization of a recombinant MAT-II enzyme from Leishmania infantum (similar to mammalian MAT II). The protein contains seven cysteine residues which function ... the etiological agent of visceral leishmaniasis, Leishmania donovani, as well as the relevance of cysteine residues to both the AdoMet synthesis and the PPP i hydrolysis activi...

Ngày tải lên : 08/03/2014, 08:20

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Báo cáo khoa học: Leishmania donovani phosphofructokinase Gene characterization, biochemical properties and structure-modelling studies doc

... exclude the enzyme as a target for selective inhibitors that bind with high afﬁnity, particularly irreversibly binding inhibitors. The most important aspects to consider in drug target selection are ... Coombs, G.H. (1985) Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals. Exp. Parasitol. 59, 151–160. 35. Reinh...

Ngày tải lên : 23/03/2014, 21:21

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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt

... Medical Genetics and Biochemistry, University of Fukui, Japan 3 Division of Legal Medicine, University of Fukui, Japan 4 Third Division of Internal Medicine, University of Fukui, Japan Deoxyribonuclease ... 1a. Results Mapping of transcription initiation sites in the human DNASE1 gene To identify the transcription initiation sites of DNASE1 in pancreas, 5¢-RACE based on RNA ligase- mediat...

Ngày tải lên : 19/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Parvalbumin deficiency in fast-twitch muscles leads to increased ‘slow-twitch type’ mitochondria, but does not affect the expression of fiber specific proteins doc

... identical to those in WT SOL (i. e. signiﬁ- cantly higher than in WT TA). Thus, PV deﬁciency induces regulated mitochondrial biogenesis of ‘slow- twitch’ mitochondria in TA, resulting in a mitochondrial ... chronic exercise [8]. The mechanism of control of mitochondrial biogenesis in muscles in response to muscle activity, as well as the mechanism controlling differential biogenesis of...

Ngày tải lên : 19/02/2014, 07:20

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Báo cáo khoa học: Super life – how and why ‘cell selection’ leads to the fastest-growing eukaryote doc

... certainly relevant, as it will increase upon an increase in s ⁄ v ratio, and ultimately begin to limit further increases in growth rate [67]. In general, targeting sites of major control with inhibiting ... fastest independently replicating organism, relatives of which are used commercially as ‘living factories’. The fastest-dividing organisms are micro-organisms, and we limit our analy...

Ngày tải lên : 16/03/2014, 04:20

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Báo cáo khoa học: Solution structure of 2¢,5¢ d(G4C4) Relevance to topological restrictions and nature’s choice of phosphodiester links docx

... families: BFI (Fig. 4A) with 39 structures, and BFII (Fig. 4B) with 20 structures when the starting model was ideally iso BDNA; and AFI (Fig. 4C) with 85 structures and AFII (Fig. 4D) with 15 s ... peaks, respectively. At this level o f NOE inte nsity quantification, spin diffusion is not expected to influence the distance restraints to a significant extent. Even so, the larger the n...

Ngày tải lên : 16/03/2014, 18:20

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Báo cáo khoa học: Leishmania infantum LeIF protein is an ATP-dependent RNA helicase and an eIF4A-like factor that inhibits translation in yeast docx

... affects translation in mammalian cells as it does in yeast, and whether it has cytotoxic effects because of its sequence similarity to eIF4AIII. In this regard, it is interesting that Leishmania EF- 1a, ... Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinan...

Ngày tải lên : 23/03/2014, 10:20

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Báo cáo khoa học: Overexpression of putative topoisomerase 6 genes from rice confers stress tolerance in transgenic Arabidopsis plants ppt

... OsTOP6A2, OsTOP6A3, and OsTOP6B increased in response to auxin and cytokinin, indica- ting their role in cell proliferation and hormone signa- ling. The interaction of OsTOP6A3 with OsTOP6B along with ... classi- ﬁed into two types, according to their ability to cleave one (type I) or both (type II) strands of a DNA double helix [1,2]. Type II topoisomerases can be divided into...

Ngày tải lên : 30/03/2014, 10:20

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