Báo cáo khoa học: Functionally different pools of Shiga toxin receptor, globotriaosyl ceramide, in HeLa cells doc

... species composition of the cel-lular Gb3[28,29]. In in vitro binding assays, the fattyacid chain of Gb3was found to in uence the bindingto Shiga toxin [30,31]. In this study, we investigated ... Authors Journal compilation ª 2006 FEBS Functionally different pools of Shiga toxin receptor, globotriaosyl ceramide, in HeLa cells Thomas Falguie`res1,*, Winfried Ro¨mer1, Mohamed Amessou1, ... microdomains of the raft type often increasesupon ligand binding.Plasma membrane dynamics of Gb3 In the next step, we investigated how Shiga toxin in uences the plasma membrane dynamics of Gb3.Ultrastructural...

Báo cáo khoa học: Does different orientation of the methoxy groups of ubiquinone-10 in the reaction centre of Rhodobacter sphaeroides cause different binding at QA and QB? potx

... E.(1994) Binding sites of quinones in photosynthetic bacterialreaction centers investigated by light-induced FTIR diﬀerencespectroscopy: binding of chainless symmetrical quinones to theQAsite of ... (1994) Binding sites of quinones in photosynthetic bacterialreaction centers investigated by light-induced FTIR diﬀerencespectroscopy: assignment of the interactions of each carbonyl of QA in Rhodobacter ... stretching vibration of QAby  60 cm)1[10,11], indicating strong asymmetricbinding of UQ10at the QAsite, in contrast to symmetric,weaker binding of UQ10at the QBsite [12,13].To explain...

Báo cáo khoa học: Two different types of hepcidins from the Japanese ﬂounder Paralichthys olivaceus ppt

... Expression of mam-malian hepcidins is induced by interleukin-1,interleukin-6, LPS and iron overloading [6–8]. Mousehas two distinct hepcidins. Both genes are predomin-antly expressed in the liver ... expression of Hep-JF2 in kidney increased after injection of iron-dextran andduring iron overloading.Up-regulation of hepcidin gene expression by LPSThe gene expressions of Hep-JF1 and Hep-JF2 in ... of human hepcidin, while the number and posi-tions of cysteine residues in Hep-JF1 are the same asthose in type II hepcidin of winter ﬂounder. Both genesexist as single copies in the Japanese...

Tài liệu Báo cáo khoa học: "Evaluating the Accuracy of an Unlexicalized Statistical Parser on the PARC DepBank" docx

... and of differing syntactic annotation of similar infor-mation, which lead to problems mapping betweenour GR output and the current DepBank. Finally,differences in the linguistic intuitions of ... nodes representing lemma-afﬁx-tags and arcs representing named grammati-cal relations. The encoding of this mapping withinthe grammar is similar to that of F-structure map-ping in LFG. However, ... extended in a variety of ways – for example, by pruning PoS tags but al-lowing multiple tag possibilities per word as in- put to the parser, by incorporating lexical subcate-gorization into parse...

Tài liệu Báo cáo khoa học: "Arabic Tokenization, Part-of-Speech Tagging and Morphological Disambiguation in One Fell Swoop" pdf

... use the no-tion of ambiguity class in the feature classiﬁers; in- stead we investigate different ways of using the re-sults of the individual feature classiﬁers in directlychoosing among the ... a total of 71machine learning features per word. We specify awindow of two words preceding and following thecurrent word, using all 71 features for each word in this 5-word window. In addition, ... request.575velopment, training, and test corpora with roughly12,000 word tokens in each of the development andtest corpora, and 120,000 words in each of the train-ing corpora. We will refer to the training corpora...

Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx

... of Serb122 is hydrogen-bonded to the amide oxygen of theg-acetamide side chain of the corrin ring in glyceroldehydratase (red dotted line in Fig. 4B). In diol dehydra-tase, the corresponding ... mode of cobalamin bindingTo identify the Co-coordinating base, EPR spectra of thesuicidally inactivated complexes of the enzyme with unla-beled and [imidazole-15N2]-labeled adenosylcobinamide3-imidazolylpropyl ... certainamino-acid residues, because the C-terminal three residues of aD, the N-terminal 45 residues of bD, and the N-terminal36 residues and the C-terminal three residues of cDweremissing...

Tài liệu Báo cáo khoa học: "THE BY RESOLUTION OF LOCAL SYNTACTIC AMBIGUITY THE HUMAN SENTENCE PROCESSING MECHANISM" doc

... underlining was not present in the experimental items.) The amount of inferencing required to process the relative target was manipulated by changing the (underlined) wording in the preceding ... suspicious of& quot; ("inferencing") to "had his doubts about" ("minimal inferencing"). Apart from finding strong effects of context (thereby replicating Crain's ... in the "minimal inferencing" condition vs. 385 msec in the "inferencing" condition). It would appear, then, that much of the evidence cited in the literature concerning...

Báo cáo khoa học: Site speciﬁcity of yeast histone acetyltransferase B complex in vivo pot

... treatment.To investigate whether HU induces an increase of the Hat1 protein, we used a yeast strain expressing ahemagglutinin (HA)-tagged version of Hat1. TheHat1–HA protein level did not increase ... histoneloading, did not detect differences in the amount of histone H3 between the two strains, indicating that cells lacking Hat1 display normal levels of histonesduring the course of HU treatment.To ... pro-cess. In yeast, the substitution mutation of Lys5 andLys12 of histone H4, in combination with deletion of the histone H3 N-terminus, does not result in defectivechromatin assembly, either in vitro...

Báo cáo khoa học: Cloning and characterization of the genes encoding toxic lectins in mistletoe (Viscum album L) pot

... However, the amino acidsforming the catalytically active center of the A-chains of the MLp toxins are fully conserved and retained in corresponding positions, as in the A-chain of ricin [27] andMLI ... B-chain andposition of the carbohydrate-binding sites areindicated. Each B-chain domain is composed of three homologous subdomains a, b, c andlinking k subdomain which joins the B-chainto ... ﬁlm.Activity of recombinant A-chains in reticulocyte lysateThe biological activity of the recombinant MLpA-chains was determined by their ability to inhibit[3H]Leu incorporation into protein in a...

Báo cáo khoa học: Molecular dynamics structures of peptide nucleic acidÆDNA hybrid in the wild-type and mutated alleles of Ki-ras proto-oncogene ppt

... deciphering theorigin of the destabilization and hence, diminution of the melting temperature (Tm) in the former.Base stacking in the vicinity of A C mismatch in PNAÆDNA and DNA duplexesIntra ... endo domain.DiscussionBase pair mismatch in duplex DNA contributes an ele-ment of instability resulting in lowering of the meltingtemperature and increase in free energy. Surprisingly,the ... at one of the fewcritical positions of ras proto-oncogenes results in asingle amino acid substitution in p21 [30] causingmalignancy [31]. One such point mutation, occurring in codon 12 of the...

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