Báo cáo khoa học: Upregulation of endothelial adhesion molecules by lysophosphatidylcholine pptx

... 2573–2584 ª 2007 The Authors Journal compilation ª 2007 FEBS Upregulation of endothelial adhesion molecules by lysophosphatidylcholine Involvement of G protein-coupled receptor GPR4 Yani Zou 1 , Chul ... protein pathway, resulting in upregulation of adhesion molecules. Further evidence showed that overexpression of human GPK4 enhanced lysophosphatidyl- choline-induced...

Ngày tải lên: 30/03/2014, 09:20

... word -by- word translation often proves deficient with respect to simple English connec- 16 j. w. perry tives such as of and “to.” In spite of these shortcomings word -by- word translations of ... the case of certain crystals (a number of which do not possess center of symmetry) polar- ization can be caused by mechanical and also by thermal action. Electrical polarization...

Ngày tải lên: 16/03/2014, 19:20

... removal of the disintegrin domain of ADAM10 did not grossly affect shedding of APP in cell culture experiments [23], cleavage of some sub- strate molecules is likely to be influenced by noncata- lytical ... diseases, upregulation of ADAM10 might also be beneficial: the reduction of all species of the prion protein in ADAM10 overexpressing mice was accompanied by a prolonge...

Ngày tải lên: 16/02/2014, 09:20

... activa- tion of DR5 after MG132 treatment was not affected by the knockdown (Fig. 5A). Furthermore, the knockdown of CHOP did not result in a significant attenuation of apoptosis induced by TRAIL ... cells, we investigated the effect of MG132 on DR5 upregulation in the pres- ence of the JNK-specific inhibitor SP600125 by wes- tern blot analysis. At concentrations of 10–30 lm...

Ngày tải lên: 18/02/2014, 17:20

... clea- vage of both FAK (106 ± 12% of intact FAK) and p130 Cas (91 ± 11% of intact p130 Cas ) proteins. Meval- onate alone had no effect on the integrity of focal adhesion proteins (101 ± 11% of intact ... Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem 272, 26056–26061. 21 Levkau BB, Herren B, Koyama H, Ross R & Raines EW (1998) Caspase-mediat...

Ngày tải lên: 23/03/2014, 11:20

... blocked by antioxidants, it appears that the generation of ROS may be involved in the induction of PAI-1 expression by TNFa via the activation of NF-jB. Results Upregulation of PAI-1 expression in endothelial cells ... )680 of the PAI-1 promoter. This reaction involves the TNFa- induced generation of superoxide leading to activation of NF-jB, and can be abolished by an...

Ngày tải lên: 30/03/2014, 11:20

... solu- tion of ThT and the fluorescence intensity of the solu- tion was measured at 482 nm. Figure 4A shows the kinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 ... aggregation even in the absence of com- ponents of mitochondrial complex I. In contrast to the effect of dopamine on the aggregation of a-synuclein alone, in the presence...

Ngày tải lên: 14/02/2014, 19:20

... the presence of various concentrations of 2A2 mAb. The binding of 2A2 mAb was followed by native gel elec- trophoresis. Increasing the concentration of 2A2 mAb at a fixed molar ratio of cathepsin ... & Bjork I (2000) Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of...

Ngày tải lên: 18/02/2014, 11:20

... hydrolysis of triolein by purified recombinant rat adipocyte HSL, with a decrease in the effect of bis-ANS upon PKA phosphorylation of HSL. The interaction of HSL with bis-ANS was found to have a K d of ... typically incubated for a period of 30 min at 37 °C before the reaction was quenched by the addition of 3.25 mL of methanol ⁄ chloroform ⁄ heptane (10 : 9 : 7) and 1.1 m...

Ngày tải lên: 18/02/2014, 11:20

... presence of this enzyme in different tissues with properties of endothelial NOS, nNOS, and ⁄ or iNOS [14,31,32]. In different models of sepsis and tissues, the existence of both mtNOS and i-mtNOS isoforms ... formation of O 2 – through the partial reduc- tion of oxygen by one electron. Subsequent reduction by one or two electrons can yield H 2 O 2 , and HO, respect- ively [4...

Ngày tải lên: 19/02/2014, 00:20