Báo cáo khoa học: Prions and prion diseases docx

Ngày tải lên: 30/03/2014, 09:20

... 597–601. MicroRNAs and cardiovascular diseases K. Ono et al. 1630 FEBS Journal 278 (2011) 1619–1633 ª 2011 The Authors Journal compilation ª 2011 FEBS 58 Rowland RT, Meng X, Cleveland JC, Meldrum ... disease and that, when miR-1 is overexpressed in normal and infracted rat hearts, this results in a slowed conduction velocity, excessively prolonged repolarization and the induction of...

Ngày tải lên: 14/02/2014, 19:20

... protein science and cell biology. However, large and slow-fold- ing fluorescent proteins may influence the folding of their fusion partner, and, in the case of prion disease and other conformational diseases, ... were stained with FlAsH (B) or CrAsH (C), and imaged under the confocal microscope. In cells that express TCC (Bb and Cb) and TCN (Bc and Cc), FlAsH and CrAsH selec...

Ngày tải lên: 06/03/2014, 11:20

... sites of chronic inflammation in prion- infected animals can alter the organ tropism of prions [56–58], and the activation of these immune cells may also facilitate prion replication in peripheral organs ... MacPherson GG (2004) Dendritic cells and oral transmission of prion diseases. Adv Drug Deliv Rev 56, 901–913. 50 O’Neill LAJ (2002) Toll-like receptor signal transduc- tion an...

Ngày tải lên: 07/03/2014, 05:20

... for insightful comments and suggestions. References 1 Turk E, Teplow D, Hood L & Prusiner S (1988) Purifi- cation and properties of the cellular and scrapie hamster prion proteins. Eur J Biochem ... Syn- thetic mammalian prions. Science 305, 673–676. 4 Legname G, Nguyen HO, Baskakov IV, Cohen FE, Dearmond SJ & Prusiner SB (2005) Strain-specified characteristics of mouse synthet...

Ngày tải lên: 23/03/2014, 10:21

... Carbohydrate, glycolysis Lactococcus lactis Modeling Pi explicitly and regulation of pyruvate kinase (by Pi and FBP), PFK (by PEP) and GAPDH (by NADH) are critical to describe observations (rapid increase in PEP, Pi and gradual decrease ... metabolite concentrations and metabolic fluxes, both measured and nonmeasured. A general parameter sensitivity analysis is carried out to deter...

Ngày tải lên: 14/02/2014, 14:20

... H4-K5, K8 and K12 acetylation [136–138]. In yeast, this group is made up of NuA4 and Piccolo NuA4 which both uti- lize Esa1 as the HAT, and Esa1 was found to be essen- tial for H4-K5, K8 and K12 ... acetylation and deacetyla- tion, and transient recruitment of remodellers and transcription factors. A cycle of transcription commences with the recruit- ment of transcription factor...

Ngày tải lên: 14/02/2014, 18:20

... tumors and cell lines, miR-17- 5p and miR-20a are induced in a manner that depends on cyclin D1 and repress the expression of cyclin D1. Hence, miR-17-5p ⁄ 20a and cyclin D1 form a feedback loop and ... transcription factors E2F and Myc but, in turn, miR-17-92 downregulates the expression of E2F and Myc [52]. In tumor progression, the tran- scription repressors ZEB1 and SIP1...

Ngày tải lên: 14/02/2014, 19:20

... signaling [11], cardiovascular diseases [12] and carcinogenesis [13]. The biogenesis and RNAi functions of miRNA (i.e. how miRNAs are generated and processed into a mature form, and how they regulate ... cancer. DNMT 3A and 3B DNMTs 1, 3A, and 3B are key DNA methylation enzymes. Recent studies in human cells have demon- strated that PRC2 and DNMTs are physically and function...

Ngày tải lên: 14/02/2014, 19:20

... binding and cleav- age by ribonuclease A and variants at Lys7, Arg10, and Lys66. Biochemistry 37, 12121–12132. 31 Anderson DG, Hammes GG & Walz FG Jr (1968) Binding of phosphate ligands to ... where I i (h) and I(h) are the ith and the mean measurements of the intensity of reflection h, respectively. R cryst = R h |F o ) F c | ⁄ R h F o , where F o and F c are the observed and...

Ngày tải lên: 14/02/2014, 22:20