Báo cáo khoa học: [Na+]i-induced c-Fos expression is not mediated by activation of the 5¢-promoter containing known transcriptional elements ppt
Tài liệu Báo cáo khoa học: Hepatic stimulator substance mitigates hepatic cell injury through suppression of the mitochondrial permeability transition pdf
... decreasing the activity of caspase-3 in the three cell lines. Effect of HSS knockdown on CCCP-induced apoptosis To further elucidate the functional role of HSS in CCCP-induced apoptosis, the expression ... to the uncoupling of oxidative phosphorylation. MPT is caused by the opening of the nonselective, highly conductive PTP in the mitochon- drial IM [39]. The...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx
... [30]. Thus, the role of L-PGDS in adipogenesis and diabetes-related phenotypes is not clear. Moreover, because of the dual functions of L-PGDS, whether PGD 2 regulates the differentiation of adipocytes ... distribution of adipose tissues as determined by computed tomography (C T) analysis To further assess the effect of H-PGDS overexpression on the increase in adip...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
... in the AP2 domain of RAP2.4 does not affect assembly with BPMs, this does not rule out a possible role of the domain for this type of interaction. However, to date, there is no evidence that the ... expression in 3-day- old seedlings in cotyledons and in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves were sta...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: Phenol hydroxylase from Acinetobacter radioresistens S13 Isolation and characterization of the regulatory component docx
... of PHI to either the complex PHR- PHO or to PHR alone, in the stoichiometry ratio PHR : PHO : PHI 2 : 1 : 1 (Fig. 5). On the contrary, the emission spectrum of PHO-bound ANS is not affected by the ... The absence of redox centres (FAD, Fe/S) excludes the first hypothesis and therefore a direct involvement of PHI in electron transfer. This conclusion is consistent...
Ngày tải lên: 21/02/2014, 00:20
Tài liệu Báo cáo khoa học: Evidence for proteasome dysfunction in cytotoxicity mediated by anti-Ras intracellular antibodies pdf
... occurs in the cell whenever the degradative capacity of the proteasome is exceeded. It is thought to be a symptom of saturation of the UPS [12,13]. To verify whether the expression of aggregating ... release and activation of caspase 3 (data not shown). This appears to be a general mechanism, which is not dependent on the presence of the intracellular a...
Ngày tải lên: 21/02/2014, 00:20
Báo cáo khoa học: a-Fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation docx
... sup- pression of apoptosis and enhancement of the malignance and therapy resistance of tumors [39–43]. The existence of a high background level of antiapoptotic factors in the cytosol of tumor cells often ... cancel their resistance to apoptosis. There are several hypotheses that may help to explain these findings. The release of cyt-c from the mitochondria into the c...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: UDP-galactose 4-epimerase from Kluyveromyces fragilis – catalytic sites of the homodimeric enzyme are functional and regulated docx
... dissociation–association. In the absence of this information, Scheme 1 is not valid. Subse- quently, we verified whether the Michaelis–Menten relationship is or is not maintained by the enzyme. When product ... case of inactivation by trypsin, the profile distinctly indicated the existence of a stable intermediate between 0.1 mm and 0.2 mm of the inhibitor. Thi...
Ngày tải lên: 16/03/2014, 00:20
Báo cáo khoa học: 2-Oxo acid dehydrogenase complexes in redox regulation Role of the lipoate residues and thioredoxin pot
... the inactivation. This is in good accord with the independence of the inactivation on the presence of oxygen. The dihydrolipoate -mediated inactivation of E1 at low NAD + concentrations is more ... Participation of the 2-oxo acid dehydrogenase complexes in the redox regulation of metabolism. The redox state of the surrounding medium is sensed by the co...
Ngày tải lên: 17/03/2014, 09:20
Báo cáo khoa học: TioS T-TE – a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides potx
... rich resource for the discovery of novel pharmaceutical agents. The biosyn- thesis of the oligopeptides can be either carried out via a ribosomal strategy, as in the case of capistruin or patellamide, ... Encouraged by the results obtained, and to investigate the mechanism of macrocyclization, the steric demand of the C-terminal amino acid was further increased by...
Ngày tải lên: 23/03/2014, 06:20
Báo cáo khoa học: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation doc
... analysis system Leica Q500MC (Leica). Analysis of fatty acid and TG metabolism To assess the effect of inhibition of fatty acid synthesis on TG accumulation, THP-1 macrophages infected with either Ad.CMV.adipophilin ... The mechanism of TG accumulation in human monocyte–macrophages primarily involves the direct uptake of free fatty acids generated by the extracellular lipo...
Ngày tải lên: 23/03/2014, 10:21