Báo cáo khoa học: Signaling pathways and preimplantation development of mammalian embryos potx

... FEBS 4359 REVIEW ARTICLE Signaling pathways and preimplantation development of mammalian embryos Yong Zhang 1 , Zhaojuan Yang 1 and Ji Wu 1,2 1 School of Life Science and Biotechnology, Shanghai ... Rac, and Rac can induce JNK ⁄ MAPK signaling. Dkk1 and SOX7 are antagonists of Wnt signaling. Both are identified as direct targets of the p38 and JNK pathways....

Ngày tải lên: 30/03/2014, 03:20

... to quickly and cheaply evaluate the impact of new ideas, algorithms, and data sets. BLEU and re- lated metrics work by comparing the output of an MT system to a set of reference (‘gold standard’) translations, ... communicative goal; and that corpus texts are often not of high enough qual- ity to form a realistic test. 2.2 Automatic evaluation of generated texts in MT and...

Ngày tải lên: 24/03/2014, 03:20

... dis- tribution of the energy between the overall tumbling and the internal mobility, and is indicative of the degree of internal restraint of each 15 N– 1 H vector motion. In Fig. 4, most of the points ... graph of R 1 , R 2 and { 1 H}– 15 N NOE val- ues along the sequence of the TTF1 HD at 11.7 T and 286 K. Fig. S2. Plot of J(0.87x N )–J(0) correlation from 15 N relax...

Ngày tải lên: 18/02/2014, 16:20

... Pro, Val or Lys, c-carboxylation of Glu, glycosylation of Ser or Thr, bromination of Trp, sulfation of Tyr, cyclization of N-terminal Gln, and epimerization of several different residues. It ... structure of conomarphin was similar to those of other conotoxin cDNAs. The cDNA-encoded precursor of conomarphin consisted of a conserved M-superfamily signal peptide of 25 re...

Ngày tải lên: 18/02/2014, 17:20

... and the CFU counted. The per- centage of surviving CFU was calculated by the formula N ⁄ N control · 100, where N and N control were the numbers of CFU obtained after 3 h of incubation with and ... (2006) Secretion of serine peptidase by a clinical strain of Candida albicans: influence of growth conditions and cleavage of human serum proteins and extracellular matrix co...

Ngày tải lên: 18/02/2014, 17:20

... concentration of Rep245 pre- pared in 10 mm sodium phosphate (pH 7.4) was 5 lm. CD spectra were recorded at 60, 70 and 80 °C between 190 and 260 nm with a step increase of 0.2 nm, and a bandwidth of 1 ... presence of 0.2 mm dNTPs and 0.5 U of Taq DNA polymerase (Promega). To analyze the effect of temperature on primase activity, Rep245 and Rep516 proteins were incubated...

Ngày tải lên: 18/02/2014, 18:20

... software swiss-pdbviewer and visual molecular dynamics [49]. Acknowledgements We thank G. Magni and S. Ruggieri for helpful com- ments and suggestions and T. Begley (Department of Chemistry and ... electrophoresis of the PCR product indicated the presence of two distinct bands between 1000 and 1100 bp of roughly the same extent (not shown). Clo- ning and nucleotide seque...

Ngày tải lên: 19/02/2014, 02:20

... catalytic proper- ties of HpSDH and the effects of pH and temperature on HpSDH. The results show that HpSDH has a k cat of 7.7 ± 0.9 s )1 , K m of 0.148 ± 0.028 mm and k cat ⁄ K m of 5.2 · 10 4 m )1 Æs )1 toward ... shikimate, k cat of 7.1 s )1 and K m of 0.182 mm toward NADP, k cat of 5.2 s )1 and K m of 2.9 mm toward NAD. The optimum pH of the enzyme activity i...

Ngày tải lên: 19/02/2014, 05:20

... domains and have a similar mode of activation [1]. There are two isoforms of S6 kinase, S6K1 and 2. Both have highly homologous kinase and kinase extension domains flanked by the less conserved N- and ... activated by an array of mitogenic stimuli and is a key player in the regulation of cell growth. The activation process of S6 kinase involves a complex and sequential se...

Ngày tải lên: 19/02/2014, 07:20

... bonds between NH of Thr5 and CO of Arg2, as well as NH of Arg2 and CO of Thr5. Structure of cyclic hexapeptides – cYT peptide. The NMR data of the cYT peptide wer e indicative of its flexible nature. ... structure of peptide cER consists of two b-turns, located at the N- and C-termini. A comparison of the b-turn structure of cER with the similar region in the crysta...

Ngày tải lên: 19/02/2014, 13:20