Báo cáo khoa học: Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c pot
Báo cáo khoa học: Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c pot
... 6295–6308 ª 2008 Institute of Genomics and Integrative Biology. Journal compilation ª 2008 FEBS Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c Preeti Sachdeva 1,2 , ... and anti-anti-sigma factor, the loss of kinase activity of Rv1364c and UsfX appears to form a missing link in the phosphorylation-dependent interac- tion i...
Ngày tải lên: 30/03/2014, 02:20
Báo cáo khoa học: Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family pdf
... protein bands of 52 kDa. These results suggest that the Myc tag fusion in the C-terminus of THTR1 protein may interfere with the cellular expression and/or stability of the protein. In view of ... THTR1 protein lacks thiamine transport activity. Furthermore, this finding is in accord with Rogers syndrome patients carrying this D93H mutant protein which apparently lost t...
Ngày tải lên: 30/03/2014, 20:20
Báo cáo khoa học: Loss of sense transgene-induced post-transcriptional gene silencing by sequential introduction of the same transgene sequences in tobacco pot
... overexpressed as a result of the interaction of RNA silencing. The instability of transgene expression has often been observed in offspring and, in some cases, overexpression and silencing of the transgene ... phenotype in S44-SH lines. After self-pollination, the offspring of three lines (S44-SH2–4) showed increased 18:3 content in leaves relative to that of the wild-type...
Ngày tải lên: 22/03/2014, 21:20
Báo cáo khoa học: Regulation of the muscle-specific AMP-activated protein kinase a2b2c3 complexes by AMP and implications of the mutations in the c3-subunit for the AMP dependence of the enzyme docx
... AMP-activated protein kinase kinase; CAMKKb,Ca 2+ ⁄ calmodulin-dependent protein kinase b; CBS, cystathionine-b-synthase; TAK1, transforming growth factor b-activating kinase 1; ZMP, 5-aminoimidazole-4-carboxamide ... Momcilo- vic M, Johnstone SR, Carlson M & Carling D (2005) Ca2+ ⁄ calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein k...
Ngày tải lên: 30/03/2014, 08:20
Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... levels remained decreased. There is evidence showing that oxidative stress contrib- utes to the inhibition of CYP activity observed in the absence of changes in protein e...
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
... elevations in the expression of activating transcription factor 4 (ATF4) and of CCAAT⁄ enhancer-binding protein homologous protein (CHOP) proteins downstream of eIF2a were observed (Fig. 4A), indicating ... long-chain saturated fatty acids (SFAs) led to increased expression of proin- flammatory cytokines, inhibition of insulin signaling, induction of endoplasmic reticulum (ER...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Structure of the putative 32 kDa myrosinase-binding protein from Arabidopsis (At3g16450.1) determined by SAIL-NMR docx
... classified as a myrosinase-bind- ing protein- like protein. Myrosinase is a glucosinolate- degrading enzyme [4], and myrosinase-binding protein (MyroBP) has been identified as a component of high-molecular-mass ... 27.5°Cat 1 H fre- quency of 800 MHz. In the case of the SAIL protein, 2 H decoupling was applied during the 13 C chemical shift evolution. SAIL-NMR structure of a myr...
Ngày tải lên: 18/02/2014, 14:20
Tài liệu Báo cáo khoa học: Binding of N- and C-terminal anti-prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse doc
... dilutions of samples (Fig. 2). Linearity consisting of continuous signal increase and of repro- ducible glycoprotein patterns was determined in the range between 4 and 10 lL of brain homogenate ... Comparison of the PrP C banding patterns of various species detected by amino- and carboxyl-binding antibodies. After immuno- blotting, PrP C proteins were detected using N- or C-term...
Ngày tải lên: 19/02/2014, 02:20
Báo cáo khoa học: Roles of conserved arginines in ATP-binding domains of AAA+ chaperone ClpB from Thermus thermophilus pptx
... these three arginines in TClpB. By combining an arginine mutation with the WalkerA mutation in the other AAA+ module, we tested the roles of the arginines in ATP binding and hydrolysis in each module. ... of the hexameric form, but not for the ATP-induced motion of the middle domain. Results The conserved arginines are not involved in nucleotide binding To examine the roles o...
Ngày tải lên: 06/03/2014, 00:20
Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx
... factor-jB in the anti -in ammatory action of glutamine, the stimulatory role of activating protein- 1 and the inhibitory role of C/EBP homology binding protein in growth-promotion, and the role of c-myc ... addition in endothe- lial cells, resulting in inhibition of endothelin-1 expres- sion [37]. In these two cases, the presence of amino acid(s) resulted in inhibit...
Ngày tải lên: 07/03/2014, 00:20