Báo cáo khoa học: Natural polyphenols as proteasome modulators and their role as anti-cancer compounds doc

... 2008 FEBS REVIEW ARTICLE Natural polyphenols as proteasome modulators and their role as anti-cancer compounds Laura Bonfili 1 , Valentina Cecarini 1 , Manila Amici 1 , Massimiliano Cuccioloni 1 , ... cancer Phase II Bronchial dysplasia Phase II Prostate cancer Phase II High-grade prostatic intraepithelial neoplasia Phase II Breast cancer Phase II Nonmetastatic bladder can...

Ngày tải lên: 30/03/2014, 02:20

... mammalian lens and guard against ischemic and reper- fusion injury due to heart attack and stroke. On the other hand, mutated sHSPs are implicated in diseases such as desmin-related myopathy and they have ... aB-crystallin and HspB2, develop as expected under nonstress conditions and show normal contrac- tility [85]. However, when exposed to ischemia and Small heat shock pro...

Ngày tải lên: 19/02/2014, 18:20

... 665 and 937, shown in (C) and (E). However, there are only few similarities: 7232 and 7237 in (A) and (E), or 7509 and 7514 in (A) and (C). An obvious shift is the appearance of higher mass peaks ... server (http://www.expasy.org/) or the peptide mass calculator (http://rna.rega.kuleuven.ac.be/masspec/pepcalc.htm). To correlate observed mass peak data, masses of various N- and C...

Ngày tải lên: 19/02/2014, 02:20

... of the isomer was dissolved in 10 lL 100 m M NH 4 HCO 3 (pH 8.0) and 0.5 lg endoproteinase V8 was added. HPI was used as a positive control in each enzyme digestion. The reaction was carried out ... gradient was 25% B to 65% B linear in 35 min. The flow rate was 0.5 mLÆmin )1 and the detection wavelength was 210 nm. The characteristic peaks on HPLC were manually collected, lyophilized a...

Ngày tải lên: 19/02/2014, 12:20

... nosocomial diseases [3]. P. aeruginosa has considerable infectious potential, as it can infect both surface tissues, such as skin and wounds, and inter- nal organs, such as the lungs and urinary ... ethanol were added, and the mixture was cooled to 0 °C. The sam- ple was then centrifuged (12 000 g, 15 min, 0 °C), and the pellet was sonicated in a solution of Tween-20 and tet...

Ngày tải lên: 07/03/2014, 05:20

... ring of IDN5390 and Leu217, His229 and Leu230, as well as between the C4 acetate and Phe272, Pro274 and Leu371. IDN5390 too is engaged in two hydrogen bonds involving the oxetane ring and the C2¢ ... interac- tions are shown in Fig. 7. The position of the ligand in the E1 and E3 structures is not as similar as in the case of paclitaxel and IDN5390 and, especially in E3,...

Ngày tải lên: 16/03/2014, 13:20

... with aldolase, lactate dehydrogenase and triose phosphate isomerase showing quite promising behavior as detection tools, drug targets and vaccine candidates [5–8]. P. falciparum enolase (Pfen) ... of enolases. Most of the enolases are inhibited by Na + ,whereasthe effect of K + depends on the source of the enzyme. K + has no effect on yeast enolase whereas it activates rabbit enolases [...

Ngày tải lên: 16/03/2014, 18:20

... one of the most difficult tasks of natural lan- guage processing. In machine translation we are confronted with the related task of target word se- lection - the task of deciding which target ... paragraphs classify these sources into two major types, based on either understanding of the text or frequency characteristics of it. One kind of information relates to the under- standing o...

Ngày tải lên: 17/03/2014, 08:20

Ngày tải lên: 23/03/2014, 03:20

... non-trivial for single-document summarization, as it has long been recognized as an actual strategy taken by human summarizers (Jing, 1998; Jing and McKeown, 2000) and acknowledged early in ... identification, interpretation, and summary generation (Hovy, 2005). In the simple case of extraction, topic identification and interpretation are conflated to sentence selection an...

Ngày tải lên: 23/03/2014, 16:20