Báo cáo khoa học: Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways docx
Báo cáo khoa học: Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways docx
... affecting signaling
pathways.
Enrichment ranking of both signaling pathways and
GOs indicated apoptosis to be the most enriched. The
miRNA–mRNA interaction network analysis further
integrated the bioinformatic ... staining assay;
the positive rate is determined by comparing the number of red ⁄
green double-stained cells with the number of desmin-positive
cells. (B) The mRNA levels o...
Tài liệu Báo cáo khoa học: Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2 pptx
... major interaction site for the adenine
moiety. In b1, an arginine residue (Ile417 in rPDE2)
binds to N1 and a threonine (Ser419 in rPDE2) inter-
acts with N7 and the N
6
amino group. The inter-
actions ... (Phe433 ⁄ Asp434 in rPDE2) that interacts
with the pyrimidine ring of the purine, either individu-
ally or in various combinations in 12 different con-
structs, enhanced cAM...
Tài liệu Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix doc
... protease;
carboxymethyllysine.
A striking characteristic of normal aging in long-lived
animals is the gradual decline in their physiological func-
tions. This decline is associated with an increase in reactive
oxygen ... immunological signals increased with
aging. These findings are consistent with previous reports
showing an increase in carbonyl proteins in mitochondria
from...
Báo cáo khoa học: Changes in specific lipids regulate BAX-induced mitochondrial permeability transition pptx
... mPTP-opening induced by rBAX
To gain insight into the existence of putative mito-
chondrial lipid microdomains in vivo, we evaluated the
inducing effect of rBAX on opening of the mPTP
in kidney ... insertion. Conversely, in hypothyroid mitochondria, rBAX inser-
tion was diminished dramatically compared with control mitochondria.
The membrane and protein changes associated with t...
Báo cáo khoa học: Changes in acetylcholine receptor function induce shifts in muscle fiber type composition docx
... tropo-
nin I
slow
. Troponin I
fast
, however, is not changed in a
reciprocal manner, indicating that troponin I
slow
and
troponin I
fast
respond independently to distinct fast
and slow signaling pathways ... 10–15 min, and then
in ATP staining buffer (3.6 mm ATP, 20 mm barbital,
18 mm CaCl
2
, pH 9.4) for 2 h. Incubation in 1% CaCl
2
for
10 min was followed by incubation in 2% Co...
Báo cáo khoa học: "Adaptivity in Question Answering with User Modelling and a Dialogue Interface" pptx
... We
introduce adaptivity in QA and IR by cre-
ating a hybrid system based on a dialogue
interface and a user model. Keywords:
question answering, information retrieval,
user modelling, dialogue interfaces.
1 ... expansion, which consists in
creating additional queries using question word
synonyms in the purpose of increasing the recall
of the search engine. Synonyms are obtained via
the...
Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... may lie within
their respective mRNA sequences that contains within it
the information needed to determine their stability within
the cells. Interestingly, Kondo et al. have identified, in the
3¢-untranslated ... through various protein kinase and monomeric
GTP-binding protein signaling pathways including MAP
kinases and Rho GTPases [18,20,31]. To determine the
signal transduction pathw...
Báo cáo khoa học: a-Fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation docx
... [28]. To determine
whether AFP is involved in this process, we established a
typical cell- free system using HepG2 cells and measured
caspase activation in this system with or without addition
of ... standard. This indicates that AFP
may be involved in formation of the high-molecular-mass
multimeric complexes with cytosolic proteins and
may modulate protein–protein interactions...
Báo cáo khoa học: Cold exposure and associated metabolic changes in adult tropical beetles exposed to fluctuating thermal regimes ppt
... exposure and associated metabolic changes
Generally, cold stress is associated with an increase in
the levels of several FAA during the first days in most
species tested to date, resulting in an increase ... regimes in the
beet armyworm [23].
In the present study, we investigated the impact of
cold exposure and associated metabolic changes in a
year-round active beetle,...
Báo cáo khoa học: Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa potx
... metarhodop-
sin Ib, proposed to interact with transducin without activating it. This may
be one of the causes contributing to the molecular mechanisms underlying
cell death associated with some retinitis ... transducin.
J Biol Chem 263, 2119–2122.
48 Liu X, Garriga P & Khorana HG (1996) Structure and
function in rhodopsin: correct folding and misfolding in
two point mutants i...