Báo cáo khoa học: Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine⁄chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-jB pdf

... Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine ⁄ chemokine production in endothelial cells via activation of both mitogen-activated protein ... proinflam- matory cytokine ⁄ chemokine production by activating mitogen-activated protein kinases and nuclear factor-jB in endothelial ce...

Ngày tải lên: 30/03/2014, 01:20

... studying protein folding. In addition, this protein contains a large number of charged amino acids, including 20 negatively charged residues and 32 positively charged residues (more than 35% of ... (E129G) and 43.43% (E75G) lower than that of the wild-type protein, suggesting that Glu residues at positions 75 and 129 play key roles in maintaining the native structure of...

Ngày tải lên: 07/03/2014, 21:20

... reaction(s). Fate of the adenosyl group of AdoCbl in inactivation of a mutant holoenzyme during catalysis To study the fate of the adenosyl group, the upper axial ligand of AdoCbl, in the inactivation of the Sa224A ... spectrum obtained at 30 min of incubation. In the case of the Sa224A mutant, how- ever, the peak at 478 nm increased gradually upon prolonged incubation,...

Ngày tải lên: 23/03/2014, 06:20

... Japan; 4 Peptide Institute Inc, Protein Research Foundation, Minoh, Osaka, Japan Previously, we isolated a 4-kDa peptide capable of binding to a 43-kDa receptor-like protein and stimulating protein kinase ... capability of binding of insulin and the 4-kDa peptide to the 43-kDa protein is similar, in our previous paper we named the 4-kDa peptide as leginsulin. But the 4-kDa...

Ngày tải lên: 31/03/2014, 07:20

... effective in protecting the enzyme from inactivation and its effect was again dose-dependent, suggesting that inhibition by DON occurs at the active site or the glutamine-binding site of the enzyme ... group of glutamine in yeast [4], while glutamate is the source of the ring nitrogen in E. coli [5]. Recently, two independent groups identified pyroA and SOR1 (PDX1) as participa...

Ngày tải lên: 19/02/2014, 12:20

Ngày tải lên: 08/03/2014, 01:20

... nature of protein glycation, the existence of specific protein targets is quite intriguing. An interesting feature is how nondividing yeast cells neutralize the harmful effects of protein glycation. Answering ... and a high rate of methylglyoxal formation, hinting that glycation might occur in these cells [21]. Protein glycation by methylglyoxal in yeast, monit...

Ngày tải lên: 30/03/2014, 20:20

... participating Table 1. Amino acid frequencies (%) in a-amylase linkers, in a set of globular proteins, in the Swiss-Prot databank and in intrinsically unstructured proteins. Amino acid Linkers a Globular proteins b Swiss-Prot c Intrinsically unstructured proteins b Ala ... remain unfolded, extended and flexible. Keywords glycoside hydrolases; intrinsically disordered proteins; p...

Ngày tải lên: 14/02/2014, 18:20

... Levels of the RAN binding protein 1 were reduced in a-syn cells with respect to b-gal cells and RuvB-like 1 is upregulated in a-syn cells in the absence of dopamine. CRMP4, a member of a family of ... dopamine treatment, overexpres- sion of a-synuclein significantly affected the levels of four proteins [stathmin 1, glutathione S-transferase (GST)p, Ran 1 binding pr...

Ngày tải lên: 15/02/2014, 01:20

... basis of ligand recognition by PABC, a highly specific peptide- binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. EMBO J 23, 272–281. 9 Craig A (1998) Interaction of polyadenylate-binding protein ... Bag J (2006) Reduced stability of mito- gen-activated protein kinase kinase-2 mRNA and phos- phorylation of poly (A)-binding protein (PABP1) in...

Ngày tải lên: 18/02/2014, 12:20