Báo cáo khoa học: Modelling and simulating interleukin-10 production and regulation by macrophages after stimulation with an immunomodulator of parasitic nematodes potx

... factor. Discussion We modelled the production and regulation of IL-10 via ERK and p38 signalling by macrophages after Av17 stimulation. Quantification of IL-10 in the super- natant over a certain time course ... Modelling interleukin-10 production and regulation FEBS Journal 276 (2009) 3454–3469 ª 2009 The Authors Journal compilation ª 2009 FEBS 3469 Modelling a...

Ngày tải lên: 29/03/2014, 23:20

... The inhibition of HGFA by PCI is competitively impaired by APC in the presence of heparin. Figure 2 shows a possible mechanism of PCI-mediated regulation of HGFA and regulation of the protein ... by pretreatment with antibody against human PCI. The regulation of HGFA by PCI was also shown in humans, as PCI levels were observed to decrease and levels of HGFA–P...

Ngày tải lên: 22/03/2014, 21:21

... family kinases in health and disease – loss -of- function of BTK and ITK and the gain -of- function fusions ITK–SYK and BTK–SYK Alamdar Hussain 1,2, *, Liang Yu 1,3, *, Rani Faryal 1,2 , Dara K. ... and Rlk ⁄ Txk in T lym- phocytes: cross -regulation of cytokine production and T cell fates. FEBS J 278, 1980–1989. 41 Qi Q, Kannan AK & August A (2011) Tec family kinases:...

Ngày tải lên: 14/02/2014, 18:20

... occurs at an early stage of tumorigenesis, as illustrated by the detection of high titers of autoantibodies in patients with early-stage cancer [64], and correlates with the progression of malignant ... to leukemia, pancreatic cancer and normal pancreas, and one of them is the only acetylated residue in cervix tumor. Three acetyla- tions are common to both leukemia an...

Ngày tải lên: 14/02/2014, 19:20

... concentration of enzyme active sites was determined by titration with MeOSuc-AAPV-CH 2 Cl and measurement of Fig. 6. Inhibition of elastase-2 by H-TNVV-OMe (amino acids 60–63 of eglin c) with and without ... co-poly- mers of the 4- and 6-sulfate isomers (Ch4S, Ch6S) with various compositions and mean molecular masses that depend on animal species and tissue. Figu...

Ngày tải lên: 16/02/2014, 14:20

... final elongation step of 10 min at 72 °C. All PCR products (NTAIL, PNT and SIC1) were digested with DpnI and purified by precipitation with ethanol, restricted with ClaI and NcoI, checked by agarose (0.8%, ... ellip- ticity values per residue of proteins 1 and 2, respectively, and n 1 and n 2 correspond to the number of residues of proteins 1 and 2. When recordin...

Ngày tải lên: 18/02/2014, 04:20

... gametogenesis and neuro- genesis, in the maintenance of sensory and ciliated tissues, and in immune responses [12–14]. HSF1- and HSF3-mediated mechanisms of cellular adaptation to heat shock have been analyzed ... except for human HSF3. Expression of classical heat shock genes induced by two heat-responsive HSFs After the identification of mammalian HSF1 and HSF2 [20–22],...

Ngày tải lên: 18/02/2014, 04:20

... the enhanced uptake of rhodamine dyes inhibited the efflux of these dyes from the cells. The efflux of rhodamine 123 and TMRM was inhib- ited by NBD-Cl and MK571 and, to a lesser extent, by ATP ... medium by centrifugation through an oil cushion and dissolved prior to determination of the amount of dyes associated with them. The advantages of such an assay are tha...

Ngày tải lên: 18/02/2014, 13:20

... buffer supplied with the enzyme, and contained Aba, Abb and Abcat 40 nm each, and the start and stop primers Abstart and Abstop at 600 nm each, and 200 lm each of dATP, dCTP, dGTP and dTTP. The ... the length and complexity of the purification procedure. Moreover, as with the studies by Lee et al. [21] and Subramanian and Shree [42], there was no rigorous assessme...

Ngày tải lên: 18/02/2014, 13:20

... signaling and loss of apoptosis [141]. Silencing of FASL and TRAIL-R1, TRAIL-R2 and Caspase-8 expression by DNA methylation has been linked to resistance of small cell lung cancer cells to FASL and ... mem- brane raft composition, on the one hand [91,172–178] and the DNA-methylation status [26–28] of many genes (e.g. FAS and CLU), on the other hand. EGCG can bind to GpC-...

Ngày tải lên: 18/02/2014, 14:20