Báo cáo khoa học: Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism docx

... compilation ª 2009 FEBS 3453 Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism Michelle Cook Sangar 1 , Hindupur K. Anandatheerthavarada 1 , ... of 250 lLÆmin )1 was used with solvents A (0.1% HCO 2 HinH 2 O, v ⁄ v) and B (0.1% HCO 2 Hin CH 3 CN) and the gradient: t 0–1 min, 100% A; t 1 min; t 1–1 6...

Ngày tải lên: 29/03/2014, 23:20

... bind, leading to a reduced P450 producing a char- acteristic CO-binding difference spectrum with an absorbance maximum at 450 nm. This P450 CO com- plex is inactive and has given the name to P450 ... domains involved in heme binding and proton transfer [2]. P450s have been categorized in families and subfamilies. They belong to the same family when they share ‡ 40% amino acid i...

Ngày tải lên: 22/03/2014, 16:21

... binding of ACP to the docking site followed by a conformational change in ACP proposed to inject the acyl chain into the sub- strate-binding pocket [32]. If a similar mechanism is involved in ... statistics. WT–C8 WT H298Q H298Q–C12 H298E H298E–C12 K328A K328A–C12 K328R Resolution (A ˚ ) 15. 0–2 .40 29. 7–1 .9 26. 1–1 .86 116. 4–1 .95 32. 5–2 .20 31. 6–2 .00 29. 8–1 .70 37....

Ngày tải lên: 19/02/2014, 08:20

... didn’t understand the previous instruction; and handleStatusInformation gets called once per second and after each user action to inform the server of the player’s position and orientation and the ... player in a 3D game world with an NLG system over the Internet. It is imple- mented and open source, and can be a used online during EACL at www.give-challenge.org. In Section 2,...

Ngày tải lên: 22/02/2014, 02:20

... contrast, recombinant Ste12 and Tec1, both produced in insect cells, are capable of binding individually to an FRE-containing oligonucleotide in vitro (Fig. 2C, lanes 1 and 2), and form a higher-order ... the binding of recombinant maltose-binding domain-Ste12 fusions or Ste12 DNA-binding domain fragments to an FRE [15], or the FUS1 promoter in vitro [23]. We have expressed 6-His-...

Ngày tải lên: 06/03/2014, 22:21

... queries to the headline and leading text than if they were to apply their queries to the full text. Documents in our news database have several text fields including HEADLINE and BODY fields. ... these documents in order to include the logical lead in most instances. Using a fixed amount of leading text regardless of document length would have resulted in LEADs that include...

Ngày tải lên: 17/03/2014, 07:20

... of RIP1 and subsequent binding to the ubiquitin-recognition domain of NEMO. NEMO itself can be conjugated to linear polyubiquitin chains joined head-to-tail by the linear ubiquitin chain assembly ... NEMO a C-terminal ubiquitin bind- ing zinc finger in conjunction with the NOA ⁄ UBAN confers much higher affinity for binding K63-linked polyubiquitin chains than head to tail conjugated lin- e...

Ngày tải lên: 28/03/2014, 23:20

... cyanide-insensitive alternative oxidase and an antimycin-insensitive, myxothiazol-sensitive, quinol- cytochrome c oxidoreductase [1]. It also contains active membrane-bound NAD + -independent D -and L -lactate dehydrogenases ... reaching phase III. In consequence, the iLDH/COX ratio increased in the three culture media, from 0.4 to 0.5 in phase I, to 0. 8– 2.0 in phase III. D...

Ngày tải lên: 30/03/2014, 20:20

... (Goodman and Gao, 2000) as well as lower- ing the complexity of related clustering algorithms (Whittaker and Woodland, 2001). In (Emami and Jelinek, 2005) a clustering algo- rithm is introduced ... linearly in the size of the vocabulary. With N pre c and N suc c denoting the average number of clusters preceding and succeeding another cluster, B denoting the number of distinct bi...

Ngày tải lên: 31/03/2014, 00:20

... to show a higher affinity for mitochondrial heavy strand promoter and light strand promoter [13]. TFAM binding to DNA induces unwinding and bending [14], and the mitochondrial TFAM content (approximately ... fusion proteins, implying involvement of these residues in nuclear targeting. Interestingly, mutations in three invariant residues (P66, W88, and K96) resulted in a signi...

Ngày tải lên: 07/03/2014, 05:20