Báo cáo khoa học: Role of calcium phosphate nanoclusters in the control of calciﬁcation pot

... importance of serum fetuin A (FETUA), osteopontin (OPN) andmatrix Gla protein (MGP) for inhibiting the precipita-tion of calcium phosphate (CaP) in serum and prevent-ing ectopic calciﬁcation of soft ... scattering was used toconﬁrm that a plasmin phosphopeptide of one of the identiﬁed proteins,osteopontin, formed a novel type of calcium phosphate nanocluster in which the radius of the amorphous calcium ... used to describe the bindingisotherms obtained previously for the b-casein 1–25 phos-phopeptide in this pH range, and the same model wasadapted to ﬁt the binding isotherm of OPN 1–149 mea-sured...

Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx

... ele-ments, very little is known about their role in DIDOactivity. The combination of domains (domain shufﬂing)is a driving force in Eukarya in the acquisition of KeywordsCGBP; DATF1; DIDO1; DIO; ... from the other bran-ches, which was indeed predicted. The other maingroup, obtained 97% of the time in 20 740 exploredtrees, contained the DIDO PHD sequences clusteredwith the PHF and the ... modiﬁcations of chromatin [9]. Little isknown, however, of the functional role of the remain-ing subclass members. In this study, the yeast protein SPP1 (alias cps40), amember of the COMPASS...

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated transcript. Taken together, these ﬁndingsprovide a compelling argument for the role for malo-nyl-CoA in regulating ... [13,23,28,30–33]. The genetic evidencefor the role of AMPK in the hypothalamus is less clearbecause the loss of the AMPKa2 subunit in speciﬁchypothalamic cell types resulted in the opposite pheno-type to ... entry of fatty acid into mitochon-dria. Thus, the steady-state level of malonyl-CoA in these tissues is determined by the relative activities of ACC and malonyl-CoA decarboxylase. Role of the...

Báo cáo khoa học: A novel retinol-binding protein in the retina of the swallowtail butterﬂy, Papilio xuthus docx

... staining of the gel indicates that the ﬂuorescing protein is one of the major components of soluble proteins in the crude extract. The surface of the ﬂuorescing protein carries negative charge in ... cellular retinal-binding protein; CRBP,cellular retinol-binding protein; IRBP, interphotoreceptorretinoid-binding protein; RBP, retinol-binding protein.Note: The nucleotide sequence reported in this ... ligand-binding protein in the ﬂy chemosensoryhair [26]). The calculated pI value of the Papilio RBP is 4.92; the protein is highly acidic. This explains the high mobility of the protein in the native...

Tài liệu Báo cáo khoa học: "A HYBRID APPROACH TO REPRESENTATION IN THE JANUS NATURAL LANGUAGE PROCESSOR" pot

... defining the set of items that have ever been the actor in a flight. Their definition is solely within NIKL using the QUA link [14], which is exactly the set of fillers of a slot. While having ... expressions in inten- sional logic. 3 4. Use of the Taxonomy in Janus By domain mode/we mean the set of axioms en- coded in NIKL regarding the constants. The domain model serves several purposes in ... all of the definitions of approximately 200 items from the base vocabulary using the defini. tJons of those vocabulary items themselves in the dictionary. In this attempt, we encountered the...

Tài liệu Báo cáo khoa học: An engineered disulﬁde bridge mimics the effect of calcium to protect neutral protease against local unfolding docx

... the introduction of the disulﬁde bridge (at5mm CaCl2and 25 ° C) is obtained. The in uence of calcium ions on the unfoldingkinetics The in uence of the calcium ion concentration onunfolding ... relatedto the position of the introduced disulﬁde bridge thatis located in the vicinity of calcium binding-site III(Fig. 1). To assign the contribution of bound calcium ions at calcium binding-site ... unfolding region 56–69 determine the stability. The disulﬁde bridge in G8C/N60C mimics the occupation of calcium binding-site IIISimilarly to the occupation of calcium binding-site III, the introduction...

Tài liệu Báo cáo khoa học: "Language Resources Factory: case study on the acquisition of Translation Memories" potx

... help them during the designphase, being able to reuse workﬂows (or parts of them) and thus avoiding reinveinting the wheel.4 Using the tools to work with NLPAll the aforementioned tools were installed, ... continue processing the rest of the input data if the workﬂow is robust (i.e. makesuse of retry and parallelisation) and the error isconﬁned to a WS (i.e. it does not affect the rest of the ... facilitate the acquisition of Language Resources. We build a factorythat automates the stages involved in the ac-quisition, production, updating and mainte-nance of these resources. The factory...

Báo cáo khoa học: A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin pot

... lysine or arginineresidue. Hence, peptide fragments not featuring alysine or arginine residue in the C-terminal ends ortruncated in the N-termini by some amino acids rela-tive to the preceding ... Critchley DR (1996) Acidicphospholipids inhibit the intramolecular associationbetween the N- and C-terminal regions of vinculin,exposing actin-binding and protein kinase C phosphory-lation sites. ... media of cells with non-activatedmeprina ⁄ b (Table 1). These unique protein spots weretherefore absent in the corresponding other condition.Thus, unique spots were indicative of proteins releasedinto...

Báo cáo khoa học: A new molecular tool for transgenic diatoms Control of mRNA and protein biosynthesis by an inducible promoter–terminator cassette docx

... beadded to induce instantaneous expression of the pro-tein of interest, allowing observation of the protein’s in uence on the progression of the cell cycle and the silica biogenesis. As the regulation ... todetermine the 5¢ end of the CfNR cDNA, allowingunequivocal identiﬁcation of the gene’s start codon.On the basis of these data, the CfNR gene is made up of 2619 bp of intron-less sequence encoding ... 40% of the primary bio-logical production in the oceans [1,2]. In addition totheir role in global carbon cycling, diatoms haverecently attracted interdisciplinary interest because of their...

Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf

... stabilityfor crystallins is essential in maintaining lens transparency[4]. Determining the mechanism of folding and assembly of these proteins is important for understanding how they canform stable ... concentrations. The d2-crystallin in lens was recruited during evolutionfrom argininosuccinate lyase, an enzyme involved in arginine biosynthesis derived from the urea cycle. Thesetwo proteins shared ... monomerswere in a molten globule state under these conditions. The similar binding aﬃnity (% 60 lM) of ANS to protein in the presence or absence of GdnHCl suggested the potentialassembly of crystallins...

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