Báo cáo khoa học: Function of microRNA-375 and microRNA-124a in pancreas and brain doc

... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the ... neurogenesis and neuronal migration in different parts of the mouse brain. HSF1 and HSF2 might interact in the develop- ing mouse brain in a stage- and tissue-specific re...

Ngày tải lên: 18/02/2014, 04:20

... define the operation of adjoining. Consider the adjoining of/ ~ at the node marked with * in a. The subtree of a under the node marked with * is excised, and/ 3 is inserted in its place. Finally, ... marks as to the linguistic significance of restrict- ing the use of regular sets in the functional uncer- tainty machinery by showing that the linguistic theory instantiat...

Ngày tải lên: 21/02/2014, 20:20

... property of not only the compounds in this series but also of other linear inhibitors [44]. The positioning of the inhibitor in the active site results in a tight interaction between the inhibitor’s ... A ˚ on one of the sides leading to loss of the interaction with O of Gly127 but instead making contact with C and O of Gly149. Optimization of the P2/P2¢ side chains Th...

Ngày tải lên: 08/03/2014, 02:20

... processing of one or several nuclear proteins, whereas the other is independent of the processing capacity of the protein- ase and involves the HPX domain. A DNA-binding domain was found in the ... illustrated in Fig. 2B (step 1). Interactions with small integrin-binding ligand N-linked glycoprotein (SIBLING) Individual members of the SIBLING family are known to bind strongly to...

Ngày tải lên: 15/03/2014, 00:20

... 6521 REVIEW ARTICLE Function of microRNA-375 and microRNA-124a in pancreas and brain Nadine N. Baroukh 1 and Emmanuel Van Obberghen 1,2 1 INSERM U907, Faculte ´ de Me ´ decine, Institut de Ge ´ ne ´ tique ... miR-124a in development and their role in the establishment of organ identity. In addition, several studies have demonstrated that Function of miR-375...

Ngày tải lên: 29/03/2014, 22:21

... consists of the rapid binding of the N-terminus of the partner, regardless of whether it is a twin-arginine signal peptide or not, followed by its release once cofactor loading and protein folding ... only minor confor- mational changes upon binding the twin-arginine signal peptide of NapA [18]. In this case, biogenesis of the NapA protein is assisted by NapF in charge of...

Ngày tải lên: 16/02/2014, 14:20

... efficiency of the siRNAs and their binding to the RNA-induced silencing complex loading complex proteins HIV transactivating response RNA-binding protein and Dicer in H1299 cytoplasmic extracts. Binding ... cells, the dsRNA binding proteins HIV transactivating response RNA-binding protein (TRBP) and Dicer recognize and bind the siRNA and form RNA-induced silencing complex (RISC)...

Ngày tải lên: 18/02/2014, 06:20

... side-chains of K89, residue 90 and residue 97 are shown. The dis- tances between the e-amino groups of K89 and K90, and between the e-amino group of K90 and the guanidino group of R97, in the ... because of the intrinsic flexibility of the loop containing His124 and the crystal packing effect. Destabilization mechanism of So-RNase HI A combination of the six thermos...

Ngày tải lên: 18/02/2014, 13:20

... pivotal roles in develop- ment and in health and disease [1]. Their properties have been studied by a combination of in vitro analy- ses of human primary ECs and in vivo analyses of genetically ... Uterus Brain DAPI A B C D tsA58T Ag Merge Brain Uterus Brain Fig. 3. Endothelial cell culture from organs of T26 ⁄ Tie2–Cre dou- ble-transgenic mice. (A) Proliferating c...

Ngày tải lên: 18/02/2014, 17:20

... transcripts during development and in adult tissues To gain insights into possible physiological functions of Cg-Clp2, determination of its tissue distribution and temporal pattern of expression during ... findings argue for an early evolutionary origin and a high con- servation of this class of proteins at both the structural and functional levels. Given the multiplicity...

Ngày tải lên: 19/02/2014, 00:20