Báo cáo khoa học: Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue pdf

... differentiation and adipose tissue expansion,hypoxia-induced neovascularization, and the relation-ship of adipose tissue with lymphatic circulation. Adipose tissue Adipose tissue depots and obesity Obesity ... in elucidating the key systemic and local effects of adipose tissue [1]. Many of these topics are now areas of intense research and have further supported the con-cept of adipose tissue as an ... MINIREVIEW Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue Joseph M. Rutkowski1, Kathryn E. Davis1 and Philipp E. Scherer1,21...

Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf

... from the c oils that can act asligand binding sites. An overlap of one coil of pelC and TmAFP is shown in Fig. 4 B. The overlap emphasizes the similarity of the b-strand along the TXT face of ... [53].Role of the TXT motif and water in activityExamination of the crystal structures of the insect AFPsalso revealed the presence of an array of water moleculesFig. 4. Comparison of the insect ... d. The top of the panel sho ws the protein with the T XT face oriented to wards the viewer, while the bottom shows the eﬀect of mutations on Thr residue s away from the TXT face. Red,0–10% thermal...

Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deﬁciency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

... latterdepends on (a) the structural integrity of the vascularbed of the penis; (b) the endothelium lining the cavernosal arteries and the helicine arterioles, as wellas the endothelium lining the lacunar ... measurements to assess obesity and this, inaddition to the age of the cohort being studied, hasinﬂuenced the strength of the correlation between ED and obesity. The International Index of Erectile Function ... T2DM, and the latter contrib-utes profoundly to endothelium dysfunction and ED[130,131], the concept of androgen deﬁciency reinforces the important role of androgens in vascular health and erectile...

Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx

... cells in the form of triglycerides, leads to the development of obesity. Despite the pivotal role of obesity and dyslipide-mia in the development of the metabolic syndrome and heart disease, the functional ... [36,37].Despite the pivotal role of obesity and dyslipidemia in the development of the metabolic syndrome and heartdisease, the functional interactions between adipose tis-sue and the lipid and lipoprotein ... expression of ApoE in the adipose tissue. Because other studies showed that ApoE-expression in the adipose tissue promoted lipid accumulation and adipocyte differentiation [39], one interpretation of the results...

Báo cáo khoa học: Mechanisms of obesity and related pathologies: Transcriptional control of adipose tissue development pdf

... discussion of the recent identiﬁcation of molecular mechanisms controlling the devel-opment and function of adipose tissues, as well as how these mechanisms contribute to the regulation of energy ... in a multitude of locations and consists of two major forms: white adipose tissue (WAT) and brown adipose tissue (BAT). WAT is the main site for the storage of energy in the form of triglycerideslocated ... given to the mice after the expression of the PPARc-Cre gene, then the marked cells continued toproduce LacZ because of the indelible nature of the system (ROSA26-ﬂox-stop-ﬂox-lacZ). In the otherGFP...

Báo cáo khoa học: Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulﬁram potx

... treatment[27,28]. The identiﬁcation and characterization of the molec-ular targets of DS are of prime importance in order tounderstand the pharmacological and ⁄ or toxicologicaleffects of this therapeutic ... concentrations of the non-physiological reductantdithiothreitol. These data suggest that the DS-depen-dent inhibition of NAT1 is unlikely to be a result of the formation of a mixed disulﬁde, but rather of ... inter-actions with the active site [33,34]. The incubation of NAT1 with DS (8 lm) caused 93 ± 2% inhibition of the enzyme, whereas the presence of AcCoA at 1 and 2mm decreased the extent of inhibition...

Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the ﬁsh species Seriola quinqueradiata pot

... presence of 6.4 nmol lysoPtdIns and 6.4 nmollysoPtdCho.ResultsFatty acid composition of phospholipids from tissues of yellowtail and rat The fatty acid compositions of PtdCho, PtdEtn, PtdSer and PtdIns ... abundant.In both the PtdEtn and PtdSer fractions, docosahexaenoicacid was the predominant PUFA in all the tissues. The presence of dimethylacetals in PtdEtn suggested the exist-ence of a substantial ... analysis of tissues of yellowtail. Furthermore, they indicate that the one-sidedincorporation of arachidonic acid into lysoPtdIns can beaccomplished in the presence of large amounts of docosa-hexaenoic...

Báo cáo khoa học: Mechanisms of amyloid ﬁbril self-assembly and inhibition Model short peptides as a key research tool pptx

... information required for the molecular recognition and self-assembly mediating the formation of amyloidﬁbrils. The small size of the peptides has reduced the complexity of the amyloid formation ... addition to the ﬁve in normal prionprotein (PrP) [28]. The role of the peptide repeats in the aggregation of yeast prion proteins was demonstra-ted by the observation that the conjugation of the repeats ... model based on the mathematical analysis of many peptide fragments and their analogues had clearly suggested aromaticityas one of the key parameters for predicting the rate of the ﬁbrillization...

Tài liệu Báo cáo khoa học: Mechanisms of amyloid ﬁbril formation – focus on domain-swapping doc

... ourunderstanding of the importance of different parts of the molecule and their ﬂexibility in the process of amy-loid ﬁbril formation often results more from a struc-tural analysis of the amyloid ... with those of Sanderset al. [155]. On the basis of thermodynamic and kineticdata, they concluded that oligomerization of the chicken cystatin occurred in the pre-exponential phase of the ﬁbril ... vari-ants of amyloid ﬁbrils differing in the number of ﬁla-ments and the helicity of their intertwining [22–24]. The structure of the mature ﬁbrils has been deter-mined in a limited number of cases...

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... and 482) and one Thr residue (amino acid 487) were well conservedin the KIND2 of v-KIND in all species analyzed,although not in the other KINDs. To investigate the possible involvement of these ... downstream of v-KIND overexpression [12])enhances the activity of MAP2 to bind to microtubules and promote their assembly [18], and that the inhibition of JNK1 (such as downstream of v-KIND knockdown[12]) ... structure of MAP2 and the alignment of v-KIND-binding core (BD) region of MAP2 CD2domain (702–744 aa) in human, mouse and GallusThis supplementary material can be found in the online version of this...

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