Báo cáo khoa học: Completing the hypusine pathway in Plasmodium Deoxyhypusine hydroxylase is an E-Z type HEAT repeat protein docx

... (2009) 5881–5891 ª 2009 The Authors Journal compilation ª 2009 FEBS 5891 Completing the hypusine pathway in Plasmodium Deoxyhypusine hydroxylase is an E-Z type HEAT repeat protein David Frommholz 1 , ... pro- teins involved in energy metabolism and conversion. The most significant amino acid identity to HEAT repeats in CpcE from Syn- echococcus elongates...

Ngày tải lên: 29/03/2014, 22:21

... 4A. The occurrence of an enhancement in the RUs is indic- ative of the increase in mass on the chip surface, which indicates binding. As shown in Fig. 4B, wild -type PfFabG showed strong binding, ... also changed these positively charged residues to alanines to deter- mine which of the electrostatic interactions are impor- tant for promoting the binding to PfACP. Intere...

Ngày tải lên: 23/03/2014, 10:20

... simulated in silico. Combining this method of analysis (in vitro, cell-based and in silico analysis) will facilitate systematic understanding of the underlying properties of this signaling pathway. To ... population. In order to shed light on the cause of this result, we car- ried out an in silico analysis by incorporating the inhi- bition kinetics within the existing com...

Ngày tải lên: 16/03/2014, 11:20

... Ranking We view the problem as an instance of statisti- cal ranking, a general machine learning paradigm used for example in statistical parsing (Collins, 2000) and question answering (Ravichandran ... single meeting as a test set and the remaining data as training material; for this experiment, we used the same training set as (Hillard et al., 2003). Per- formance is reported in...

Ngày tải lên: 20/02/2014, 16:20

... residues in proteins [51,52]. The utility of intrinsic protein fluorescence is limited by the fact that many proteins contain multiple tryptophan residues making interpretation of resultant spectra ... Science, Bangalore, India Plasmodium falciparum triosephosphate isomerase (PfTIM) contains two tryptophan residues, W11 and W168. One is positioned in the interior of the pr...

Ngày tải lên: 31/03/2014, 07:20

... contain different analyses of the same phrase in other sentences in the discourse often results in odd outputs of the natural language processing system. Starting from the viewpoint that an interpretation ... for completing incomplete parses by using this information. The first step of the procedure is to extract fi'om an input text discourse information th...

Ngày tải lên: 08/03/2014, 07:20

... [7]. sTF is displayed in space filling and FVIIa in C-alpha ribbon. The TF1 domain is in dark grey and the TF2 domain in light grey. The Gla domain of FVIIa is showningreen;EGF1inmagenta;EGF2inlightblue;PDindark blue. ... Gla domain, is also in contact with the Gla domain of FVIIa in this part of the binding region. Fur- thermore, a region that includes the N-te...

Ngày tải lên: 17/03/2014, 03:20

... acid and nucleotide biosynthesis, it also plays a crucial role in maintaining the cytosolic NADP + ⁄ NADPH balance. In order to maintain this balance, the flux through the oxidative branch of the ... balance mod- els for the nonoxidative branch of the pentose phosphate pathway is not in accordance with the established ping-pong kinetic mechanism of the enzymes transke...

Ngày tải lên: 23/03/2014, 15:21

... [12–14]. The separate K channel is indispensable for proton transfer linked to the reduction of the binuclear site and, consistently, mutations in this channel give rise to a drastically retarded ... from the mediators in the visible and infrared range could be detected in control experi- ments with samples lacking the protein, except for the PO modes of the phosphate...

Ngày tải lên: 30/03/2014, 15:20

... these proteins. The data therefore support the hypothesis that this N-terminal region is important for modulating the aggregation state of the proteins. In conclusion, Cu A biogenesis in humans ... hydrophobic interactions in the surroundings of the metal-binding site (Fig. 6), and only once histidine coordination is lost can Sco pro- teins acquire redox activity [85]....

Ngày tải lên: 14/02/2014, 18:20