... alcohol in the binding pocket. In clusters 1 and 3, the ring is oriented‘inside’, towards the conserved core of the bindingpocket, but in cluster 2, it is oriented towards the longloop covering the ... within the vicinity of the active site, therefore significantly reducing the sizeand accessibility of the acceptor binding pocket(Fig. S6). In SlUGT5, this tyrosine is replaced by aphenylalanine ... b-isosal-icin as the reaction product. Docking of salicyl alcoholinto the acceptor binding pocket yielded three mainbinding clusters (Fig. 4C). In cluster 1, the primaryalcohol hydroxyl group of salicyl...