... use of vitamin E and vitamin C in combi- nation reduced the prevalence and incidence of AD in an elderly population; however, the use of either of these vitamins alone had no effect [110]. Finally, ... Peroxynitrite-induced alterations in synapto- somal membrane proteins: insight into oxidative stress in Alzheimer& apos;s disease. J Neurochem 1999, 72:310-317. 87. Bonfoco E, Krainc D, Ankarcrona ... complex leads to the initiation of complex signaling events leading to protein tyrosine phosphorylation and activation of the src-family kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52]....
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16]. This finding sug- gests ... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis. Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3 Effect of indomethacin plus ... brain sections from mice on placebo or receiving indomethacin plus vitamin EFigure 6 Representative pictures of brain sections from mice on placebo or receiving indomethacin plus vitamin E. Indomethacin Vitamin...
Ngày tải lên: 19/06/2014, 22:20
Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... activation of p38 induced by oxidative stress, we further examined whether its activation is responsible for the induction of apoptosis in F9 cells using SB202190, a potent inhibitor of p38. As shown in ... important role in protection of neuronal cells against stress- induced apoptosis [26]. In accordance with these findings, ischemia/reperfusion in the rat forebrain induces the expression of HSP105/110 ... mitogen-activated protein kinase (p38). Furthermore, oxidative stress- induced apoptosis was suppressed by SB202190, a potent inhibitor of p38, in F9 cells. These findings indicated that the activation of p38...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... depolarization of in situ mitochondria by oxidative stress parallels a decrease in NAD(P)H level in nerve terminals. Neurochem Int 36, 483–488. 61 Chinopoulos C & Adam-Vizi V (1999) Depolarization of in ... imposing a continuous load of calcium to the neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase ... element binding protein, iso- citrate dehydrogenase is an RNA-binding protein, while kgd2p is a mitochondrial DNA binding protein [81–84]. Mitochondria from different brain regions contain different...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARP activation within 5 min that was inhibited by benzamide. Oxidative stress- induced ... confirming PARP activation in D. discoideum under oxidative stress. PARP inhibition during oxidative stress- induced growth changes in D. discoideum PARP inhibition conferred protection against ... observed during oxidative stress (Fig. 4A,B). Under oxidative stress, partial inhi- bition of PARP activity led to altered growth, suggest- ing that oxidative stress could be leading to cell...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... cell activity of several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein (a 12/15-LOX inhibitor), ... apoptosis. In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of many antineoplastic agents [13,14]. To investigate whether oxidative stress is involved in the ... treatment of H460 cells with 1 μM of NSC- 741909 induced cluster formation of MKP1 and MKP7 at all time points examined (2 - 8 h after the treatment) (Fig. 1A, B), suggesting that oxidative stress...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... proteins including CD59, clus- terin, vitronectin, C1-inhibitor, C4-binding protein, decay-activating factor, and Factor H, which inhibit differ- ent steps in the complement cascade. All of these ... present in the brains of Alzheimer patients, but not in the brains of patients with other demen- Journal of Neuroinflammation 2004, 1:18 http://www.jneuroinflammation.com/content/1/1/18 Page 4 of ... entorhinal cortex and the molec- ular layer of the dentate gyrus [106,107], systemic admin- istration of the excitotoxin kainic acid [108,109], or injection of the neurotoxin colchicine into the...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... response of the organism to particle-induced oxida- tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat- ing from a response to oxidative ... only 10% of urate is excreted in the urine (the remaining 90% being recirculated by the renal system [3]), an increase of this antioxidant in blood will also lead to an increase in urine. The ... been reported to increase the serum levels of uric acid in North Carolina police officers [4]. A similar increase of plasma antioxidants in response to an increased oxid a- tive stress was observed in newborns...
Ngày tải lên: 20/06/2014, 00:20
Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... PM10 suggesting that PM2.5 induced more oxidative stress than PM10. In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total plasmid DNA (form F ig. 10. RT-PCR analysis of ... analysis of Nrf-2 No remarkable change of expression level in Nrf-2, proteins related with many transcriptional and anti -oxidative stress enzyme, was observed in the groups of three concentration of ... Expression of Nrf2 protein in the PM2.5 - and PM10 - t reated rat lung epithelial cell was determined by Weste rn B lotting. The lower shows the ratio of Nrf2/actin usi ng c alculatging by densitometor....
Ngày tải lên: 07/08/2014, 17:22
Báo cáo y học: "The role of stress in rheumatic diseases" ppsx
Ngày tải lên: 12/08/2014, 14:21
Báo cáo y học: "Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure" potx
Ngày tải lên: 13/08/2014, 13:20
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... influx (41). The increased activity of NOS and the increased for- mation of NO in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of ... supply of oxygen in reperfusion group. The increased activity of arginase in reperfusion group may be beneficial by the way of competing NOS for arginine. In a recent study using GS inhibitor,...
Ngày tải lên: 26/10/2012, 09:07
Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
... the BRCA1 protein is strongly associ- ated with NFT in AD yet a feature of only about half of the cases of normal aging containing tau-positive NFT. Elevations in BRCA1 in neurons in AD may represent ... tangles of normal aging. Key words: Alzheimer disease, BRCA1, cell cycle, oncogenesis 1. Introduction Neurofibrillary tangles (NFT) are the cardinal intracellular lesion of Alzheimer disease ... altera- tions in oncogenic proteins may play a role in neurodegeneration. To this end, in this study, we examined brain tissue from cases of Alzheimer disease for the presence of BRCA1, a known...
Ngày tải lên: 26/10/2012, 10:04