Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf

... and apoptosis. Thus, Bcl-2 and Bcl-xL represent a molecular link between autophagy and apoptosis. Here, we discuss the possible roles of Bcl-2 and Bcl-xL in apoptosis and autophagy, and the crosstalk ... on how Bcl-2 and Bcl-xL are involved in the molecular events. The crosstalk between the autophagy and apoptosis may redefine the...

Ngày tải lên: 28/03/2014, 23:20

... receptors, including human RXR (which is the ortholog of USP) have shown that an area on the surface of the ligand binding domain involving the C-terminus of a-helix 3, a-helix 4, and the N-terminus of ... promoter reporter. These two motifs (DR1 and IR1) contain identical half sites and the same intervening single base, the differ- ence being the orientation of the se...

Ngày tải lên: 23/03/2014, 13:20

... mm spermidine, and maintained at 37 °C during 12 h. After inactivating the enzyme at 95 °C, during 10 min, in the presence of 5 mm EDTA, the remnant inhibitory action was assayed on the TPO enzyme ... of the time factor in signalling specificity: application to mitogenic and metabolic signalling by the insulin and insulin-like growth factor I receptor tyrosine kinases. Gl...

Ngày tải lên: 30/03/2014, 14:20

... of these materials (e.g. N e -carboxymethyl-lysines and N e -carboxy- ethyl-lysines and pentosidine) being known to accumu- late with age on tissue proteins, and at an increased rate in LDL and ... (1994) Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with Nalpha-acetylarginine, Nalpha-acetylcysteine, and Na...

Ngày tải lên: 19/02/2014, 02:20

... peroxynitrite (ONOO ) ). These findings indicate that the cysteine residues exposed on the surface of proteins are the dominant intracellular thiol and that they may play an important role in intracellular ... borohydride and mea- suring the released GSH using the glutathione recycling assay [11]. To measure the binding of [ 3 H]GSH to mitochondrial membranes, membranes (...

Ngày tải lên: 06/03/2014, 09:22

... Ponting CP (1998) Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide. ... C-terminal lysines, plays a role in fibrinolytic propagation by serving as more effi- cient binding sites for plasminogen. The high-affinity lysine-binding sites in K1 and K4...

Ngày tải lên: 06/03/2014, 22:21

... of the normal replication fork differing in the gap sizes of the lagging strand. The gaps in the RF2, RF3 and RF4 are 8, 4 and 0 bp, respectively. As shown in Fig. 7C, DmGEN cleaved the lagging ... in Fig. 2B, these active-site residues (asterisks 2 and 3 in Fig. 2B) are highly conserved in the I domain of the RAD2 ⁄ XPG family, and are important in coo...

Ngày tải lên: 07/03/2014, 10:20

... enhances the binding affinity of the dimeric DYNLT and the resulting complex will be rather stable [15,29]. On the other hand, binding of DYNLRB to the preformed com- plex does not cause further binding ... fragment containing the binding sites for LC8 and Tctex1 in complex with these two light chains [15,29], and LC8 in complex with an artificially dimer- ized binding mot...

Ngày tải lên: 14/03/2014, 22:20

... by intro- ducing the context words as nodes into the graph and linking them with their respective synsets. 3. These nodes corresponding to the context words then inject probability mass into the synsets ... class includes words which are en- countered only in the source domain D 1 and do not appear in the target domain D 2 . Since we are interested in adapting to the t...

Ngày tải lên: 17/03/2014, 00:20

... sku and BmIVD genes To determine the consistency between the sku pheno- type and the BmIVD genotype, linkage analysis between the wild-type and sku strains was performed. For this, crossing of the ... strains revealed the presence of a single point mutation in 1337 nucleotides of BmIVD. In the sku mutant, the 1127th guanine from the start codon was substituted...

Ngày tải lên: 18/02/2014, 04:20