... radiationresponse of tumor cells. However, the basis of the linkbetween the signaling pathway and the apoptotic cell-death machinery in response to ionizing radiationremains largely unclear. The aim of our ... criticallyinvolved in the apoptotic process, and is induced bymicrotubule-damaging agents such as paclitaxel, docet-axel, vincristine and vinblastine [14]. Recently, multiplekinases have ... mediate the phosphory-lation of Bcl-2 following a variety of stimuli. Theseinclude paclitaxel-activated Raf-1 [15], paclitexel- orvincristine-induced protein kinase A [16], bryostatin-1-induced...