Báo cáo khoa học: Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes docx

... FEBS Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes Jun Inoue, Yuka Ito, Satoko Shimada, ... the addition of glutamine, the gene expression of the SREBP targets, such as HMG CoA synthase and the LDL receptor, was slightly...

Ngày tải lên: 28/03/2014, 22:21

... Elevated serine ⁄ threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamem- brane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine ... been the subject of intensive research for many years. Yet, we don’t know the details of the molecular dysregulation in the target cells of the hormone....

Ngày tải lên: 07/03/2014, 16:20

... (in this case on the tumbling of the rigid part), with the extent of the perturbation being proportional to the length of the disordered region. With the aim of investigating the reciprocal confor- mational ... of disordered and ordered moieties within the fusion proteins, we calculated the theoretical average spectra of equimolar IDP and GFP mixtures by...

Ngày tải lên: 18/02/2014, 04:20

... conditions [22], but with the wall of the pore made of both lipid and pro- tein molecules. At the rim of the membrane hole, the two leaflets of the bilayer can make contact with each other, forming a membrane ... This software allows the use of different reference sets of proteins, including membrane proteins, increasing the reliability of the analysis....

Ngày tải lên: 19/02/2014, 07:20

... analysed the thermal unfolding profile of lysozyme in the presence of additives. Figure 3A shows the thermal unfolding curve of lysozyme in the presence of ArgEE as m onitored by DSC. In the absence of ... to Arg is related to the ethylation of the main chain of the carboxyl group. Figure 5B shows the amount of aggregation of lysozyme at pH 6.5 and 10.0 in...

Ngày tải lên: 19/02/2014, 16:20

... regarding the identification and distribution of TLP genes in nature, the structural and functional characterization of the TLP from various organisms, and the evolution of TLP and transthyretin. The ... in the peroxisomes of metazoan and plant species, and the co-regulation of TLP genes in some bacteria, suggests a concerted effort in the rapid genera...

Ngày tải lên: 07/03/2014, 00:20

... levels of cytokines and chemokines enhance the expression of adhesion molecules on cerebral endothelial cells, facilitating the adhesion and transendothelial migration of circulating neutrophils and ... [24–26]. These mediators induce the expression of the adhesion mole- cules ICAM-1 [27–30], P-selectin and E-selectin [31,32] and integrins [33,34] on endothelial...

Ngày tải lên: 07/03/2014, 03:20

... picture of the enzyme and should be helpful in a comprehensive under- standing of the role of hKAT-I, especially in KYNA biosynthesis in the human brain. Experimental procedures Enzyme expression and ... by their rather low affinity to the enzyme. Effects of other keto acids on hKAT-I activity Ability to function as the amino group acceptor for a number of biologica...

Ngày tải lên: 07/03/2014, 16:20

... mentioned above, the shared features are the total number and the values of the data points themselves, and the variation is given by the number of times the data points appear. Another type of bootstrap ... and the iteration of the above mentioned analyses with the experimental data gathering phase is the topic of an accompanying mini- review [56], and...

Ngày tải lên: 23/03/2014, 06:20

... isomerase and many other proteins. The active site of enolase is present at the C terminus of this barrel. The small or N-terminal domain wraps around the outside of the main domain [8]. Most of the ... possibilities for the design of selective inhibitors, although their presence in the second shell of the catalytic site, rather than in the first (Fig. 4) ra...

Ngày tải lên: 23/03/2014, 21:20