Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot
... implicated the Tec family kinases Itk and Rlk ⁄ Txk as important regulators of cyto- kine production by CD4 + effector T- cell populations. Emerging data now suggest that the Tec family kinases not ... Tec kinases contribute to human diseases involving distinct types of T- cell activation and cytokine production. In this minireview, we cover the roles of...
Ngày tải lên: 28/03/2014, 22:21
... nonreceptor protein tyrosine kinases which includes Rlk and Tec, and is important for effective signaling through the T- cell receptor (TCR) [1,2]. There are additional Tec family kinases that signal ... development [38,62]. Further analy- sis indicates that Itk regulates the migration and hom- ing, but not maturation and homeostasis, of these cd skin-resident intraepith...
Ngày tải lên: 28/03/2014, 22:21
... binding and mutation to tryptophan most probably causes instability of the SH2 domain. Thus, these patients had undetectable levels of ITK protein despite normal levels of mRNA. Consistent with this, ... ligand-binding pocket and reduce protein stability. The two patients with the R335W mutation had negligible levels of NKT cells. This suggests that NKT cells protect against inc...
Ngày tải lên: 14/02/2014, 18:20
Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation ppt
... regulator of cytokine production in mast cells. Tec is essential for efficient cytokine production upon FceRI-mediated mast-cell activation Tec is the third member of the Tec kinase family for which ... class of protein tyrosine kinases that are implicated in FceRI-mediated mast-cell activation [22]. The Tec kinase family consti- tutes the second largest family...
Ngày tải lên: 28/03/2014, 22:21
Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf
... prevent or facilitate the invasion and metastasis process, depending on the time and localization of their expression. The N-terminal part of TIMPs is involved in binding to the active site of MMPs ... been shown to regulate expression of MMPs and their inhibitors in several cell lines [10]. The protein itself has no known enzymatic activity, but binds to distinct intracellu...
Ngày tải lên: 18/02/2014, 11:20
Báo cáo khoa học: Evidence for two different electron transfer pathways in the same enzyme, nitrate reductase A from Escherichia coli potx
... site of interaction between the cytochrome and the quinones by studying inhibition of the nitrate reductase activity by HOQNO. It has therefore clarified the binding site of the menaquinols, but ... constants indicates that there are two distinct reactions, and so oxidation of the cytochrome by nitrate follows separate pathways according to the nature of the electron donor. The k...
Ngày tải lên: 07/03/2014, 15:20
Báo cáo khoa học: E1 – Protein kinases pptx
... binding, suggesting Abstracts 320 that the N-terminal, WD repeat-containing domain interacts with the plasma membrane. Through its capacity to interact with the F-actin cytoskeleton and the plasma ... cells, we tested the hypothesis that beta-catenin is linked to these kinases in neoplastic thyrocytes and that this pathway may be modulated by the selective tyrosine kinase inhibitor, G...
Ngày tải lên: 23/03/2014, 15:20
Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx
... one in the N-terminal domain, an addi- tional client-binding site exists in the C-terminal domain of HSP90. The aim of the present study is to elucidate the regions within the C-terminal domain ... protein with a Table 1. Effect of amino acid substitutions in the hydrophobic segment in the C-terminal domain of HSP90a. The bacterial two-hybrid system was used to evaluate the bin...
Ngày tải lên: 23/03/2014, 20:22
Báo cáo khoa học: A family of killer toxins Exploring the mechanism of ADP-ribosylating toxins pptx
... the YST motif. This ring stacking stabilizes the bound NAD and plays a similar role to that of the STS motif in other toxins; that of stabilizing and maintaining the structure of the active site ... NAD binding and maintains the structure of the active site cleft; (c) the Aromatic-hydrophobic- serine-threonine-serine motif (STS motif) on a b-strand that stabilizes the NAD bind...
Ngày tải lên: 30/03/2014, 10:20
Báo cáo khoa học: "Medical emergency teams: deciphering clues to crises in hospitals"
... Australia. Although there are no randomized clinical trials showing benefit from introduction of METs, many single center reports [2-4] support the notion that timely intervention may interrupt ... requiring a MET if no action is taken to prevent it. On the other hand, the MET patient may be instead a symptom of a hospital in crisis. In other words, the MET patient may be created by t...
Ngày tải lên: 25/10/2012, 10:45