Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines ppt

... ovarian carcinoma). In this study we investigated the expression pattern of the 23 MMPs, currently known in humans, in different gynecological cancer cell lines. Methods: In total, cell lines from ... same expression pattern concerning endometrial cancer cell lines. In addition, MMP-3, -10 and - 13 were expressed in cervical carcinoma and teratocarcinoma...

Ngày tải lên: 28/03/2014, 14:20

... siRNA in breast cancer cells lines abolishes the ability of estradiol to up-regulate the expression of MMP-9, highlighting the importance of signaling by estrogen receptors in the expression pattern ... release of negative regulators of angiogenesis, such as angiostatin, tumstatin, endostatin and endorepellin. MMPs also modulate the cell cell and cell ECM interactio...

Ngày tải lên: 15/03/2014, 00:20

... MMP- 9 expression in the hippocampus is involved in Ab- induced cognitive dysfunction [10]. These findings together point to the need to increase our understand- ing of the role of MMPs in AD ... study that investigated the levels of diff erent MMPs in plasma of AD patients [30]. The increased levels of seve ral MMPs in the CSF of individuals with increased risk for AD...

Ngày tải lên: 22/03/2014, 14:20

... breast cancer cell growth To investigate the role of ERa in miR-22-mediated repression of human cancer cell growth of ERa-posi- tive breast cancer cells we used two specific small inter- fering RNAs ... downregulation of miR-22 expression in ERa-posi- tive breast cancer cell lines and tumor specimens. (A) For breast cancer cell lines, the expression level...

Ngày tải lên: 22/03/2014, 21:20

... thapsigargin-induced activation of ERK1 ⁄ 2in Rat1 cells [29]. Thapsigargin-induced phosphorylation of ERK1 ⁄ 2 in HEK293 cells was inhibited by pretreat- ment with 20 lm CAI for 25 min, demonstrating ... was also eliminated in cells incubated with 20 lm H89, an inhibitor of PKA but also of other kinases [28], for 25 min prior to treatment with 10 lm serotonin (Fig. 3B). The sero...

Ngày tải lên: 19/02/2014, 18:20

... Although most cystatins inhi- biting cathepsin L also inhibit cathepsin S, an inhibitory activity of cystatin F against cathepsin S has not yet been reported. The expression of the cystatin F (CST7)andC(CST3) genes ... to be involved in invariant chain [8] and antigen [11] processing, respectively. Our present results showing a distinct intracellular localiza- tion of cystatin F are...

Ngày tải lên: 21/02/2014, 01:21

... signal (anti-Stk33 in red and anti-a-tubulin in green). (D–I) Immunostaining combined with nuclear staining in mouse lung preparations (anti-Stk33 in red and nuclear staining in blue). (D,E,F) ... anti- body staining. Immunoreactivity is observable in recombinant protein (Rec), protein extracts from testis of mice at 20 and 30 dpp but absent in 10 dpp. Coomassie blue staining...

Ngày tải lên: 16/03/2014, 23:20

Ngày tải lên: 31/08/2012, 16:33

... concept of human rights. Human rights as an article of faith According to a standard definition, human rights are those rights one has by virtue of being human. 1 This definition suggests that human ... belong to every human being in every human society: all human beings have them, equally and in equal measure. Implied in one’s humanity, human rights are generall...

Ngày tải lên: 01/11/2013, 10:20

... dpf in enterocytes of the pos- terior part of the intestine (Fig. 5M,Q,R). This last finding should be of interest because in terms of func- tion, the fish intestine is highly regionalized both in ... lumen [43,44]. Considering the importance of the intestinal barrier in the process of oral prion infection, this find- ing might help clarify the entry and routing of PrP Sc...

Ngày tải lên: 19/02/2014, 16:20