Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx

... on in ammatory cells in diseases such as asthma may offer new and effective approaches to immunomodulatory therapy. In an attempt to identify such new targets on in ammatory cells at sites of in ammation, we ... tyrosines, two of which are embedded in ITIM -signaling motifs (Y5 97 and Y6 67) and are likely involved in intracellular signaling. The ability...

Ngày tải lên: 24/03/2014, 04:21

... C-terminal domain of MABO to other proteins of the sarcosine dehydrogen ase and oxidase family may indicate that this is the site of attachment of tetra- hydrofolate to the enzyme. c-Aminobutyrate produced during ... cofactor of the enzyme. Methylene-tetra- hydrofolate may then be turned over by the bifunctional enzyme methylene-tetrahydrofolate dehydrogenase/cyc...

Ngày tải lên: 19/02/2014, 16:20

... activity of CYP17 and the differential regulation thereof have been the subject of many studies. It is apparent that the normal expression and dual hydroxylase and lyase activities of this key enzyme ... guinea pig CYP17 favours the D 4 -steroid pathway, the enzyme being incapable of meta- bolizing 17-OHPREG to DHEA [13]. Rat, porcine and hamster CYP17 catalyse...

Ngày tải lên: 08/03/2014, 09:20

... filling a gap created by a glycine in helix aA within the SH2 domain of the phosphatase [31,46–48]. The glycine is conserved in the N- and C-terminal SH2 domains of both SHP1 and SHP2 and is required ... member of this family, CIS, was cloned as an immediate- early gene induced by several cytokines. CIS has been demonstrated to bind to tyrosine-phosphoryl...

Ngày tải lên: 24/03/2014, 00:21

... breakage in three different substrates by Alcaligenes faecalis AADH [39], the fast substrates dopam- ine and tryptamine, and the slow substrate benzylamine. Again,aswithMADHandTSOX,anindicationasto ... 100-fold in a H172Q mutant TMADH [44], and by an additional factor of 4 in a Y1 69F mutant TMADH [43]. Both His172 and Tyr169 are located near the substrate-binding s...

Ngày tải lên: 31/03/2014, 23:20

... cyanobacteria, corals and other marine organisms are much more advanced than those of mammals because photosynthetic organisms depend on solar irradiation as their primary source of energy, and at the same ... bases (enamino ketones), which possess a common cyclohexenone ring system linked by an aminoacidoranamino-alcohol[11].Incontrast,MAAsare UV absorbing metabolites of alga...

Ngày tải lên: 07/03/2014, 15:20

... N-terminal 8-kDa domains. The capacity of the 8-kDa domain to bind a terminal phosphate group is particularly important for both processivity and binding of polymerase b during gap- filling synthesis ... poly- merase b, amino acids 43–52 of bovine DNA polymerase b, and amino acids 24–33 of yeast (Sac- charomyces cerevisiae and S. pombe) DNA poly- merase IV is shown i...

Ngày tải lên: 30/03/2014, 08:20

... likely that at least some of the  17 genes of the family are spaced several kb ap art (as fo r Afp-Lu1 and 2 . 7a) , e ven though they may be linked. In both Afp-Lu1 an d Afp-Iu1, the majority of the sequence ... found. AFP-Iu1 had the same polyadenylation signal, AATATA, found in the cDNA 10 isoform. Southern analysis In order to estimate the copy number of...

Ngày tải lên: 21/02/2014, 15:20

... DSC, of caseins, synucleins and tau, together with several mutants of a- synuclein and tau that cause neurodegenerative diseases. The ROA spectra of all these proteins are very similar to those of ... that, as in the caseins and synucleins, the major con formational element present in the wild-type Fig. 3. The backscattered Raman and ROA spectra of recombi...

Ngày tải lên: 21/02/2014, 15:20

... steroidogenic compartments of the adrenal gland and gonads [12], at the anterior pituitary gland and at the ventromedial hypothalamic nucleus in the brain. Confirming these histological observations, mice ... lines. MATERIALS AND METHODS Parasites A Puerto-Rican strain of S. mansoni was maintained in Biomphalaria glabrata snails and golden hamsters (Meso- cricetus aur...

Ngày tải lên: 23/03/2014, 21:20