Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells potx
Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells potx
... culture HL-60 cells, a human leukemia cell lines, were cultured in RPMI 1640 containing 10% fetal bovine serum in a 5%CO2atmosphere.Cytotoxicity of Py/Zn in HL-60 cells The cytotoxicity of Py/Zn ... that caspase activation is required for Zn-induced apoptosis in human Burkittlymphoma B cells. An increase in labile Zn in the cytoplasmmay suppress apoptosis by inhibition of the action of caspase, ... understood. In the present study, weinvestigated the role of intracellular Zn level in the induction of apoptosis in human leukemia cells (HL-60 cells) using aZn ionophore [pyrithione (Py)]. Treatment...
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Báo cáo y học: "Use of chinese and western over-the-counter medications in Hong Kong"
... role of medical professionals is a dominant factor in defining, controlling and scoping the work of theallied health professionals [21,22] as extending pharma-cists’ roleinprimarycaremayaffecttheautonomyandcontrol ... medicine community pharmacistsmight be the only point of contact when they hadminor aliments. Therefore, there is a need in promoting and extending the roles of the western medicine com-munity ... Patterns of OTC uses reflect the characteristics of populations who rely on community pharma-cists and Chinese medicine retailers as their main point of contact with the healthcare system. Analyzing...
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Báo cáo y học: "Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia"
... outcome of up-per/lower endoscopy in outpatients with iron defi-ciency anemia. The aim of our study was to investi-gate the incidence of GI pathological findings in symptomatic and asymptomatic ... evaluate the diagnos-tic yield of endoscopy in patients with IDA and to define predictive factors of gastrointestinal (GI) le-sions causing IDA and identify clinical and biochem -ical variables ... its severity calculated by presence of ab -dominal pain, abdominal pain with hungry and an -xiety, abdominal distension, nausea, vomiting, poor appetite and symptoms of gastroesophageal reflux....
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Báo cáo y học: "Characterization of N200 and P300: Selected Studies of the Event-Related Potential Salil H. Patel 1 and Pierre N. Azzam 2"
... methods, and interdisciplinary interest in its application as a prognostic, diagnostic, and investigative tool, an understanding of the underpinnings of P300 and N200 physiology may support ... possibly clinically manifesting as apathy. 3.2 P300 and the N2b Data indicate that the P300 is involved not only in processes of working memory, but may interact with the N2b in the control of ... decrease in the older population, suggesting a shortening of the sensory auditory memory trace with increasing age [19]. The same phenomenon occurs in the very young, indicating the necessity of...
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Báo cáo y học: "Comparison of Classical and Clozapine Treatment on Schizophrenia Using Positive and Negative Syndrome Scale of Schizophrenia (PANSS) and SPECT Imaging"
... passivity and apathy, difficulty in abstract thinking, lack of spontaneity and flow of conversation, and stereotyped thinking (N1 to N7); and health concerns, anxiety, guilt, tension, mannerisms and ... receptors involved in Clozapine therapy included D4, D2, serotonin type 2, norepinephrine, acetylcholine, and histamine [20-22]. Functional brain imaging methods have been applied for studying schizophrenia. ... hallucination. By contrast, drugs such as amphetamine reinforce signal transmissions by dopamine and induce schizophrenic symptoms such as delusion and hallucination. A large body of theory and...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... manganese.Selectivity of the proteins for their metal cofactor has beendemonstrated in vivo [3] and although apoenzymes of eachtype of SOD may be reconstituted by the addition of metals,the resulting enzyme ... determined by the characteristic position of a glutamine residueThe´re`se Hunter1, Joe V. Bannister1,2 and Gary J. Hunter11Department of Physiology and Biochemistry, University of Malta, ... within 2.1 A˚ of themetal ion). Azide binding residues include the three Hismetal ligands (H26, H81 and H171) and gateway residuesH30 and H34. A further gateway residue, H31, is involvedin...
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Báo cáo Y học: Ubiquitination of soluble and membrane-bound tyrosine hydroxylase and degradation of the soluble form ppt
... (1997)Molecular characterization of disease related mutant forms of human phenylalanine hydroxylase and tyrosine hydroxylase. In Chemistry and Biology of Pteridines and Folates (Pfleiderer,W.&Rokos, ... (1986) In duction of tyrosinehydroxylase by cyclic AMP and glucocorticoids in a rat pheo-chromocytoma cell line. effect o f t h e inducing ag ents alone or in combination on the enzyme levels and ... catalyzes theconversion of L-tyrosine toL-dihydroxyphenylalanine(L-DOPA), the rate-limiting step in the biosynthesis of dopamine and noradrenaline/adrenaline [ 1]. The cellularactivity of...
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Báo cáo Y học: Modelling of simple and complex calcium oscillations From single-cell responses to intercellular signalling pdf
... dynamics of the IP3R [113]. In Cacyt/protein models, the role of alternating supply and withdrawal of Ca2+is played by the fluxes of thedissociation and b inding of Ca2+to and from binding ... (1994). Nonlinear Dynamics and Chaos. WithApplications to Physics, Biology, Chemistry, and Engineering.Addison-Wesley, R eading (Mass.).31. Glendinning, P. (1994) Stability, Instability, and Chaos. ... 8–64.201. Rottingen, J.A., Cam e rer, E., Mathiesen, I., Prydz, H. & I versen,J.G. (1997) Synchronized Ca2+oscillations induced in MadinDarby canine kidney cells b y bradykinin and thrombin but...
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Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx
... R.D. (1993) Roles of cellular retinol-binding protein and cellular retinoic acid-binding protein in themetabolic channeling of retinoids. In Retinoids. Progress in Research and Clinical Applications. ... differences in NADcontents among various Xenopus tissues. Next, T3-bindingactivity of xCTBP/xALDH1 was directly examined byphotoaffinity-labeling using intact Xenopus cells. Analyses of the cytosol ... inhibitorsagainst propionaldehyde [31]. These distinct inhibitorymodes might reflect the differences of the iodothyroninebinding pocket within xALDH1 and mammalian ALDHs.The inhibitory interactions of...
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Báo cáo Y học: Effect of ibuprofen and warfarin on the allosteric properties of haem– human serum albumin A spectroscopic study potx
... theantioxidant capacity of human serum, either directly or bybinding and carrying radical scavengers, or by sequesteringtransition metal ions with pro-oxidant activity. Finally, HSAacts as a nitric ... the binding isotherms of ferric haem to HSA in the absence and presence of ibuprofen and warfarin, asobtained by electronic absorption spectroscopy at pH 7.0 and 25.0 8C. Data analysis according ... the N-form [1,3,4,14,35,36]. Haem inhibitsdrug binding, possibly stabilizing the N-species of HSA(present study). Accordingly, binding of ibuprofen and warfarin to Sudlow’s site I impairs ferric...
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