Báo cáo khoa học: Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system pot
Báo cáo khoa học: Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system pot
... Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system Aneta Ringholm1, Janis Klovins1, Robert Fredriksson1, ... char-acterization and tissue distribution of a melanocortin (MC) receptor gene in a shark, the spiny dogfish (Squalus acanth-ias) (Sac). Phylogenetic analysis showed that this receptor is an ortholog of the ... peptide), ghrelin and MSH are involved in the regulation of energy balance by binding to GPCRs in the central regions of the brain [12,13]. However, in ÔlowerÕvertebrates, the molecular mechanisms for...
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Tài liệu Báo cáo khoa học: Shaped by the environment – adaptation in plants Meeting report based on the presentations at the FEBS Workshop ‘Adaptation Potential in Plants’ 2009 (Vienna, Austria) pdf
... mechanisms involved in acquired thermotol-erance in plants. Transcriptome profiling revealed 57transcripts specifically upregulated in acclimatedplants, including heat shock proteins, transcriptionfactors ... exposuredepending on the time of day of the exposure [51].Cold induction of CBF2 involves multiple cis-actingregulatory elements, one of which binds members of the calmodulin-binding transcription ... isolate Arabidopsis lines with quantitative dif-ferences in secondary dormancy. An epigenetic recom-binant inbred line was identified that was unable togerminate in the presence of the gibberellic...
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Báo cáo khoa học: Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy pot
... enabled by quantitative PCR of key metabolic enzymesincluding uncoupling protein 2 (UCP2) and fatty acid translocase (CD36).DNA microarray analysis of gene expression changes in exercise-inducedcardiac ... exercise-inducedhypertrophy was accompanied by a marked upregula-tion of genes involved in extracellular matrix remode-ling (biglycan, matrix gla protein, cathepsins, cystatins,integrin a7 and ... acid binding protein 4 (FABP4), fatty acid trans-port protein (Slc27a1), and glucokinase regulatory pro-tein (GCKR) were upregulated and uncoupling protein2 (UCP2) was downregulated confirming...
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Báo cáo khoa học: Presence of membrane ecdysone receptor in the anterior silk gland of the silkworm Bombyx mori pdf
... determinedusing 25 nM[3H]PonA and increasing amounts of proteins in individual incubations. The percentage of specific b indingincreased in a protein concentration-dependent mannerwithin the range of ... the binding activities for[3H]PonA in the detergent-rich phase, indicating that themEcR is an integral membrane protein which might beanchored in the membrane by transmembrane sequence of hydrophobic ... for t he presence of a putative receptor for ecdysteroid in tissuemembranes and its biochemical characterization in an insect. The membrane receptor exhibits a specific andsaturable binding for...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... neuropeptide Y and agouti related peptide in hypo-thalamic malonyl-CoA while promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated transcript. Taken together, these findingsprovide ... plays a key role in maintaining energybalance [1–4]. In more advanced, mammalian systemsthere is compelling evidence for the control of energymetabolism via the central nervous system (CNS),notably ... integration of nutrient sensing in the central nervous system hasbeen shown to be an important regulator of adiposity by affecting foodintake and peripheral energy expenditure. Modulation of...
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Tài liệu Báo cáo khoa học: Amino acid discrimination by arginyl-tRNA synthetases as revealed by an examination of natural specificity variants doc
... FEBSbean and soybean. When binding of arginine in the presence of tRNA was investigated, some changes in the binding architecture were observed [35], in thatN(153:Y), in addition to interacting ... December2008)doi:10.1111/j.1742-4658.2009.06866.xl-Canavanine occurs as a toxic non-protein amino acid in more than 1500leguminous plants. One mechanism of its toxicity is its incorporation intoproteins, replacing l-arginine and giving rise ... OHL-Arginine H2NNNH2NH2NH2NH2OOHOL-Canavanine Fig. 1. Structures of L-arginine and its guanidinooxy analogue,L-canavanine.Arginyl-tRNA synthetase amino acid discrimination...
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Tài liệu Báo cáo khoa học: Enlarging the gas access channel to the active site renders the regulatory hydrogenase HupUV of Rhodobacter capsulatus O2 sensitive without affecting its transductory activity docx
... first-order kinetics, wasassayed in the absence of protein. In vitro interaction of HupUV and HupTThe proteins (50 pmol HupUV and 250 pmol HupT) wereincubated for 10 min at 30 °C in buffer containing ... proteins wereintroduced into the vessel, and the changes in D2,HDand H2were monitored by scanning masses 4, 3 and 2,Table 3. Bacterial strains and plasmids used in this study.Strain or ... lower in the mutant proteinOD7 than that of wild-type HupUV [9.2 vs. 2.0 lmolreduced benzyl viologenÆmin)1Æ(mg protein))1). Tocheck the stability of the proteins in the presence of O2,...
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Tài liệu Báo cáo khoa học: "A Method for Correcting Errors in Speech Recognition Using the Statistical Features of Character Co-occurrence" pptx
... actual utterance, and with perfect expression. (B) No lacking in meaning, but with slightly awkward expression. (C) Slightly lacking in meaning. (D) Considerably lacking in meaning. (E) Unable ... such errors. In integrating recognition and translation into a speech translation system, the development of the following processes is therefore important: (1) detection of errors in speech ... EPC+SSC. 1 Introduction In spite of the increased performance of speech recognition systems, the output still contains many errors. For language processing such as a machine translation, it...
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Tài liệu Báo cáo khoa học: "STRING-TREE CORRESPONDENCE GRAMMAR: A DECLARATIVE GRAMMAR FORMALISM FOR DEFINING THE CORRESPONDENCE BETWEEN STRINGS OF TERMS AND TREE STRUCTURES" pdf
... mapping between elements of the set of substrings of the string and elements of the set of subtrees of the tree : such a relation is called a string- tree correspondence. An example of a string-tree ... processing (say for translation into another language), where all and only the relevant conten~.s or 'meaning' (in some sense adequate for the purpo- se) of the related string are ... 162 As an immediate consequence to the above, an STCG rule thus defines a correspondence between a set of strings of terms on one hand and a set of trees on the other (by means of a linear...
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Báo cáo khoa học: A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components ppt
... Tissue-specificexpression of mast cell granule serine proteinases andtheir role in inflammation in the lung and gut. Immunol-ogy 105, 375–390.5 Caughey G (2001) New developments in the geneticsand activation of ... electron-dense secretory granules, and thesegranules are released following MC activation, a pro-cess that can be accomplished by various mechanisms,including antigen-mediated crosslinking of surface-associated ... immu-nohistochemistry, and were released following exposure to calcium iono-phore, indicating that they were correctly targeted into secretory granuleseven in the absence of serglycin. In the absence of serglycin,...
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