... mechanisms; one of these is the control of GnRH synthesis andrelease. In the past, the scarcity of GnRH neurons and their widespreaddistribution in the brain hindered the study of GnRH gene expression.Until ... Because of the recent discovery of GnRH-IIas a new isoform of GnRH, the majority of the studieshave been done on the GnRH-I promoter, and thereare only a few regarding regulation of the GnRH-IIgene. The ... have therefore variedaccording to the time at which the animals werekilled, the dose and duration of estrogen treatment,and the region of the brain analyzed [75]. During the estrous cycle, the...