Báo cáo khoa học: Perturbation of folding and reassociation of lactate dehydrogenase by proline and trimethylamine oxide potx
Báo cáo khoa học: Perturbation of folding and reassociation of lactate dehydrogenase by proline and trimethylamine oxide potx
... effects of proline and TMAO on the structure and/ or function of lactate dehydrogenase are based on investigations performed by Bolen and coworkers [3,44,45]. A study of the effect of proline ... FEBS 2003 Perturbation of folding and reassociation of lactate dehydrogenase by proline and trimethylamine oxide Oscar P. Chilson and Anne E. Chilso...
Ngày tải lên: 23/03/2014, 15:21
Báo cáo khoa học: Perturbation of membrane microdomains in GLC4 multidrug-resistant lung cancer cells ) modification of ABCC1 (MRP1) localization and functionality docx
... evidenced either by the rate of efflux of pirarubicin or that of glutathione. Further cholesterol depletion below 40% yielded both a partial shift of MRP1 to the high-density fraction and a decrease of its ... min, and 80% deple- tion being observed after 10 min of incubation; this was not modified by a longer time of incubation. Effect of cholesterol depletion on the ra...
Ngày tải lên: 30/03/2014, 09:20
Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf
... the regulatory effects of miR-23a on the expression of IL6R by RT-PCR and western blot, and found an inverse correlation between miR-23a and IL6R expression at both the mRNA and protein levels. To ... because of its higher fold of upregula- tion in gastric adenocarcinoma tissues. Although the extent of upregulation of miR-23a in the four pairs of gastric tissues showed...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Perturbation of membranes by the amyloid b-peptide – a molecular dynamics study pptx
... the perturbation of lipids, which is a result of both hydro- phobic mismatch of the C-terminal region of Ab within the lipid bilayer and the favorable interaction of the N-terminal segment of ... experienced by the nearby lipids to the motion and tilting of this embedded segment. Thinning of the bilayer in the presence of Ab40 Because Ab40 is known to disrupt the int...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf
... N-terminus of cytochrome b where it is enveloped by subunit 7. The arrows labeled (b) and (c) point to the areas of interaction between the transmembrane helix of subunit 8 and helices G and H1 of cytochrome ... overall structure of this complex and that of chicken and beef [6]. In yeast and higher eukaryotes, cytochrome b is encoded by mito- chondrial DNA, while t...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: Phylogenetic relationships in class I of the superfamily of bacterial, fungal, and plant peroxidases pptx
... evolutionary lines of class I of this superfamily occur, i.e. the CCP line and the KatG fusion line, as is the c ase for Neuro spora crassa [47]. Evolution by the birth -and- death process in class I of the superfamily ... hydrogen peroxide (i.e. the reaction of catalase) and to remain peroxidatically active (oxidation of substrates with hydrogen peroxide). In contrast, C-doma...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... N-terminal and b-he lical domains participate in binding of the polysaccharide, pullulan. Comparison of the active sites of the model of IPU and Dex49A The active site structures of t he model of IPU ... 372, and 373 are the potential catalytic r esidues of I PU. Also, Trp425 of Dex49A, which is the corresponding residue of Trp402 of IPU, is reportedly located in the...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: Evidence for interactions between domains of TatA and TatB from mutagenesis of the TatABC subunits of the twin-arginine translocase docx
... domains of TatA and TatB from mutagenesis of the TatABC subunits of the twin-arginine translocase Claire M. L. Barrett and Colin Robinson Department of Biological Sciences, University of Warwick, ... transmembrane (TM) spans of TatA and TatB, with the aim of generating structural distortions. We show that sub- stitution in TatB of three residues by glycine, or a single...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2 ppt
... Chimera 1C2 encoded residues 1–505 and 653–725 of TAP1 and residues 494–639 of TAP2 and chimera 2C1 encoded residues 1–493 and 640–703 of TAP2 and residues 506–652 of TAP1. The exchange was performed ... EcoRI site of pHbApr1neo [22] and sequenced fully in both directions. Chimera 1V2 encoded residues 1–652 of TAP1 and residues 640–703 of TAP2 and chimera 2V1 enc...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo khoa học: Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells docx
... in Materials and methods. Results are the mean and standard deviation of iron internalized by normal and iron-loaded hepatocytes from three separate experiments, and are expressed as a percentage of the ... was approved by the Animal Experimentation Ethics Committee of the University of Western Australia and is in accordance with the Australian Code of Practice for the...
Ngày tải lên: 20/02/2014, 11:20