Báo cáo khoa học: E1 – Protein kinases pptx

... PKC beta II is regulated by PI 3-kinase in HT29 human adenocarcinoma Abstracts 316 E1 – Protein kinases E1- 001 Protein interactions in cell signaling and polarity T. Pawson Samuel Lunenfeld Research ... panasyuk_g@imbg.org.ua The ribosomal protein S6 kinase (S6K) belongs to the AGC fam- ily of Ser/Thr protein kinases which includes the protein kinase C’s, protein kinas...

Ngày tải lên: 23/03/2014, 15:20

... the PH–TH domain differences between BTK–SYK and ITK– SYK fusion proteins lead to differential phosphorylation levels of the fusion proteins themselves, as well as the downstream adapter proteins ... activation of ITK–SYK and BTK–SYK To determine its activation capacity, we constructed the corresponding fusion kinase BTK–SYK, harboring the PH–TH domain doublet (amino acids 1–1 96) of BTK fu...

Ngày tải lên: 14/02/2014, 18:20

... such as receptor protein tyrosine kinase/growth factor receptor binding protein 2-son of sevenless protein/ Ras/Raf/mitogen activated protein kinase kinase/mitogen activated protein kinase pathway ... Cancer Res. 54, 326 0– 3266. 33. Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randall, R.J. (1951) Protein measurement with the Folin-phenol reagent. J. Biol. Chem. 193, 26 5–2...

Ngày tải lên: 21/02/2014, 00:20

... sur- vival [ 1–4 ]. The Akt subfamily of protein kinases con- sists of three isoforms – Akt1, Akt2 and Akt3 (also termed PKBa, PKBb and PKBc) – which are the products of distinct genes. All three proteins ... signal-regulated kinases 1 ⁄ 2 pathway. J Neurochem 77, 122 6–1 236. 35 Luttrell DK & Luttrell LM (2004) Not so strange bedfellows: G -protein- coupled receptors an...

Ngày tải lên: 16/03/2014, 05:20

... phosphoinositide-dependent protein kinase PDK1 is a Ser/ Thr protein kinase, which phosphorylates and activates a number of other protein kinases, including protein kinase PKB (also called AKT), protein kinase ... the protein structure database, protein mj1187 from the archaean M. jannaschii (pdb 1t5j). This protein is a putative Abstracts 89 ADP-ribosyl hydrolase. The ARH-pr...

Ngày tải lên: 23/03/2014, 15:20

... soluble protein 12 2–2 28 mPrP(12 2–2 28) No expression data f 12 2–2 30 mPrP(12 2–2 30) No expression data f 12 7–2 28 mPrP(12 7–2 28) No expression data f 12 7–2 30 mPrP(12 7–2 30) No expression data f 2 3–1 44 ... data e hPrP(2 3–2 22) No expression data e hPrP(2 3–2 26) No expression data e hPrP(12 1–2 26) b High-yield expression, high yield of refolded soluble...

Ngày tải lên: 18/02/2014, 08:20

... substrate (S ⁄ T)XX(D/E) – – Glycogen synthase kinase 3 (GSK3) (S/T)XXX(Sp ⁄ Tp) – Primed substrate Protein kinase B (PKB ⁄ Akt) RXRXX(S ⁄ T )– – Protein kinase C (PKC) (S ⁄ T)X(K ⁄ R) – – Tyr kinases EGF ... E)YX– – Abl tyrosine kinase (I ⁄ V ⁄ L)YXX(P ⁄ F) – SH2 domain Ser ⁄ Thr phosphatases Dual-specificity protein phosphatase 6 (DUSP6) TpXYp – – P...

Ngày tải lên: 18/02/2014, 08:20

... and SREBP-2. HEK293 cells were transfected with either 0.1 lg of pGAL4–SREBP1a (Gal4–DBD–SREBP1a) or pGAL4–SREBP2 (Gal4–DBD–SREBP2), 0.2 lg of pG5Luc containing five copies of the Gal4-binding ... Brown MS (1993) SREBP-1, a basic-helix–loop–helix-leucine zipper protein that con- trols transcription of the low density lipoprotein recep- tor gene. Cell 75, 18 7–1 97. 8 Yieh L, Sanchez HB &am...

Ngày tải lên: 18/02/2014, 13:20

Ngày tải lên: 19/02/2014, 19:20

... prokaryotes as well as eukaryotes [ 7–1 0]. The peroxiredoxin proteins show no significant homology with previously identified antioxidant proteins. The nomenclature of these proteins is still confu- sing, ... 268, 92 1–9 27. 18. Iakoubova, O.A., Pacella, L.A., Her, H. & Beier, D.R. (1997) LTW4 protein on mouse chromosome 1 is a member of a family of antioxidant proteins. Genomics 42,...

Ngày tải lên: 20/02/2014, 23:20