Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
... names PAS-40, PAS-52, PAS-70, PAS-110,PAS-151 and PAS-170. (PrtA Substrate molar mass). The N-ter-minal amino acid sequence of two PAS proteins, PAS-52 and PAS-110, identified the former as Manduca ... new inhibitors of proteases from various sources.Among known protease inhibitors from fungi are, yeasts inhibitors of proteinases A (asparagine protease) and B (serine protease), and low molecular ... perform structure- based drug design of new POP inhibitors in the future as well as to study the interaction of the candidates with the act-ive site of the enzyme.Abstracts147B1-032PPurification and...
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Báo cáo khoa học: Missense mutations as a cause of metachromatic leukodystrophy Degradation of arylsulfatase A in the endoplasmic reticulum potx
... addition of inhibitors.Influence of ER a1,2-mannosidase I inhibitionon ER exit of amino acid-substituted ASAsIn order to investigate whether stabilization of mutantASAs through inhibition of ER ... Effects of protease or phosphataseinhibitors on the stability of mutant ASAs.Ltk–cells stably expressing the indicatedamino acid-substituted ASAs were incuba-ted in the presence of various inhibitors(Lc, ... A2 and A5. After25 min of chase, precipitation with mAbs A2 and A5is almost as efficient as with mAb B1. The location of epitopes suggests that folding of ASA starts within acentral part of...
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Báo cáo khoa học: "Vocabulary Choice as an Indicator of Perspective" pdf
... percentage of the available words to ob-tain the same classification accuracy as with thefull feature set, even in high-accuracy cases such as PBA and BL. The effectiveness of a smallsubset of features ... related tasks of movie review and political party classification.We use SVMlight(Joachims, 1999) for SVM and WEKA toolkit (Witten and Frank, 2005; Hall etal., 2009) for both version of Naive ... gave20-60% support to one of the positions.2Death Penalty (DP) blogs: We use University of Maryland Death Penalty Corpus (Greene and Resnik, 2009) of 1085 texts from a number of pro- and anti-death penalty...
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Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf
... region.1.01.20.8A5700.40.60.200.51.01.59080706040503020100A570Number of colonies00.51.01.52.0A5700ASO-NC miR-23aASO24 hAB48 h72 h****pcDNA3 pri-23aASO-NC miR-23aASOpcDNA3 pri-23aASO-NC miR-23aASOpcDNA3 pri-23aASO-NC miR-23aASOpcDNA3 ... and activated T-cell populations [21]. Ingastric cancer, IL6 contains polymorphisms [22]. Theexpression of IL6 is involved in gastric cancer invasion and lymph node and ⁄ or hepatic metastasis, ... the four pairs of gastric tissues showed great variance because of the different malignancies as well as individual differ-ences, the dysregulation of miR-23a in gastric cancerwas consistent....
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Tài liệu Báo cáo khoa học: Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells docx
... range of chelators.Toxicity studies. Aspartate aminotransferase (AST)release from cells was measured using the optimized ASTkit purchased from Sigma. This was carried out at every step of the ... (mobilizationstudies). AST release was measured at every step of the experiments as described in Materials and methods. Results are the mean and standard deviation from a typical experiment (n ¼ 3), and are ... cytosol.Tren-N-Me-3,2-HOPO was only slightly less effectivethan DFP, and showed no toxicity even at 1 mM ,as assessed from the lack of change in cell morphology and AST release (Table 4). This is most encouraging as...
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Tài liệu Báo cáo khoa học: "A Composite Kernel to Extract Relations between Entities with both Flat and Structured Features" ppt
... tree through a path of non-terminals and a list of base phrase chunks. Prior kernel-based methods for this task focus on using individual tree kernels to exploit tree structure- related features. ... such as rule-based (MUC, 1987-1998; Miller et al., 2000), feature-based (Kambhatla 2004; Zhou et al., 2005) and kernel-based (Zelenko et al., 2003; Culotta and Sorensen, 2004; Bunescu and ... amounts of implicit (structured) features, until now the fea-ture-based methods enjoy more success. One may ask: how can we make full use of the nice properties of kernel methods and define...
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Báo cáo khoa học: Comparing the substrate specificities of cytochrome c biogenesis Systems I and II docx
... c550was detected in periplasmicextracts of cells containing pHP86 (H. pylori ResBC) and pKPD1 (cytochrome c550) and was quantifiedspectroscopically (Fig. 2). The yield was approximately0.6% of ... level of spontaneous heme attachment. Uncata-lyzed heme attachment to cytochrome c552is known tooccur in the E. coli cytoplasm [9], and a small amount of cytoplasmic contamination of periplasmic ... SDS-PAGE analysis of the periplasmic fractions in thisstudy demonstrated that the spontaneous holocyto-chrome formation detected was essentially all periplas-mic, as the observed mass was consistent...
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Báo cáo khoa học: DmGEN shows a flap endonuclease activity, cleaving the blocked-flap structure and model replication fork docx
... similar to those of FEN-1 and EXO-1, and the molecular mass of DmGEN wasfound to be close to that of EXO-1. Therefore, we pro-posed a new class (class IV) to categorize DmGEN and SEND-1, which ... BF2 and BF3 – were 15,17 and 19 bp, respectively (Fig. 7A). The single-stran-ded region of the BF structure was 19 bp, and the gapsizes of the blocked strand of BF1, BF2 and BF3 were4, 2 and ... biochemical properties of native and anactive-site mutant DmGEN to more deeply understandthe nature of this new class of nucleases. As for the biochemical features, class I consists of XPG homologues,...
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Báo cáo khoa học: "Speakers’ Intention Prediction Using Statistics of Multi-level Features in a Schedule Management Domain" ppt
... treated as a part of researches on dialogue models such as a finite-state model, a frame-based 229model (Goddeau, 1996), and a plan-based model (Litman, 1987). However, a finite-state model has ... given task by using shared domain knowledge. Since a frame-based model is more flexible than a finite-state model and is more easy-implementable than a plan-based model, we adopt the frame-based ... con-necting basic concepts with bar symbols) (Kim, 2007) based on Table 2. Then, we generalize speaker’s intention into a pair of a speech act and a concept sequence. In the remains of this paper,...
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Báo cáo khoa học: Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells ppt
... release of the noco-dazole block. However, in the presence of curcumin,the percentage of cells in the mitotic phase was 83% and 81% after 4 and 8 h of block release. Thus, treat-ment of cells ... combination of 8 lm curcumin and 2 nm paclitaxelwas found to be 3.1 ± 1.5. The proliferation of MCF-7 cells was inhibited by 22% and 24% in the presence of 2 and 3 nm vinblastine, respectively, whereas ... interactwith Eg5 and inhibit its function.Effects of curcumin on the progression of thecell cycleCurcumin increased the metaphase ⁄ anaphase ratio and slowed the release of mitotic block in...
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