Báo cáo khóa học: The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex pptx
Báo cáo khóa học: The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex pptx
... MG132 and the reprogramming of translation (Eur. J. Biochem. 271) 3611 The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of ... investigation into the regulation of protein synthesis in mammalian cells, we have investigated the e ffects of inhibition of the p r...
Ngày tải lên: 23/03/2014, 12:20
Báo cáo khoa học: Unique proteasome subunit Xrpn10c is a specific receptor for the antiapoptotic ubiquitin-like protein Scythe docx
... that Xrpn10c containing the 10c-box functions as a Scythe-binding receptor. We suggest that the region containing the 10c-box is a novel candidate for the UBL protein-binding domain of the 26S proteasome. It ... C-terminal fragment of Scythe (Scythe C312) in Xenopus egg extracts induced Reaper-independent apoptosis [31,32], implying the potential role of the N-terminal...
Ngày tải lên: 30/03/2014, 11:20
Báo cáo khoa học: Peptides from purified soybean b-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain pot
... to that of Orlistat with their amino acid side chains also extending into the interface cavity and short chain pocket. The poten- tial interaction modes of these peptides with the TE domain suggest ... Orlistat (77.3%) at 100 lm. Binding and interaction modes of FAS inhibitory peptides To evaluate in more detail the binding modes of these peptide inhibitors in the...
Ngày tải lên: 06/03/2014, 09:22
Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt
... grafting approach to address this question. As shown in Fig. 1B, the distance between the two termini of the inserted Ca 2+ -binding sites in the model structure of the EF-hand of STIM1 is within 15 ... Ca 2+ . Removing the proposed Ca 2+ -coordinating residues in positions 1 and 3 of the EF-hand motif significantly compromised the metal-binding capability of...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: A novel inhibitor of indole-3-glycerol phosphate synthase with activity against multidrug-resistant Mycobacterium tuberculosis pptx
... substrate and these residues, including two bonds formed with the atoms in the backbone and another two bonds formed with side chains of Glu168 and Asn189. Interestingly, they are the residues ... role in the catalytic pro- cess of mIGPS and may be related to the inhibition mechanism of ATB107. To investigate the role of these residues in the inhib- ito...
Ngày tải lên: 07/03/2014, 03:20
Báo cáo khoa học: Plasminogen activator inhibitor type-1 inhibits insulin signaling by competing with avb3 integrin for vitronectin binding pptx
... demonstrated that the inhibition of PAI-1 on insulin signaling is inde- pendent of uPAR-VN binding. These results constitute the first demonstration of the interaction of PAI-1 with the insulin response. Keywords: ... role of PAI-1 in the VN- mediated induction of insulin signaling, PAI-1 was included in preincubations with VN. There was a significant decrease in...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells pptx
... in obesity-associated insulin resistance and diabetes, inhibit insulin signalling at several points in the signalling cascade. The liver is critical in maintaining cir- culating glucose levels and, in a preliminary ... series of events beginning with the TNFa-mediated prevention of the effect of insulin on Foxa2 localization and lead- ing to the abrogation of...
Ngày tải lên: 16/03/2014, 02:20
Báo cáo khoa học: Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain pdf
... bridges in the analogs with respect to their adenosine moieties. Details of the syntheses will be published elsewhere, and we present, in the Supporting information, only the key steps leading to the ... lupin enzyme and of 2.1 lm (3) and 2.5 lm (4) for the human counter- part. These K i values lie in the range of the K m values for Ap 4 A: 2.5 lm for the...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo khoa học: A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer ppt
... a recombinant form of DT that has been engineered by replacing the native receptor-binding domain of DT with interleukin (IL)-2. This substitution alters the tar- get of the toxin from the membrane-associated ... furin at either of these sites or in the endosomal network during intracellular trafficking between them. In addition to furin cleavage of the PE polypepti...
Ngày tải lên: 22/03/2014, 15:21
Báo cáo khoa học: A monoclonal antibody, PGM34, against 6-sulfated blood-group H type 2 antigen, on the carbohydrate moiety of mucin doc
... region stained by PGM34 were almost identical with those stained by the HID and CCG labeling method (Figs 7Ab and 8). The specificities of HID staining and labeling of CCG for sulfated mucin in the ... and gland mucins are dif- ferent from each other: MUC5AC is the dominant mucin in surface mucus, and MUC6 is the dominant mucin in gland mucus [6,7]. The carboh...
Ngày tải lên: 23/03/2014, 09:21