Báo cáo khoa học: Mechanisms of amyloid fibril self-assembly and inhibition Model short peptides as a key research tool pptx
Báo cáo khoa học: Mechanisms of amyloid fibril self-assembly and inhibition Model short peptides as a key research tool pptx
... MINIREVIEW
Mechanisms of amyloid fibril self-assembly and inhibition
Model short peptides as a key research tool
Ehud Gazit
Department of Molecular Microbiology and Biotechnology, Tel Aviv University, ... interaction and self-
assembly of fibrils but also revealed that aromatic interactions are import-
ant in many cases of amyloid formation. The reali...
Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
... on
domain-swapping
‘Run-away’ and ‘propagated domain-swapping’ models
The domain-swapped oligomer can act either as a seed
for fibril elongation (propagated domain-swapping) or
as an end product (off-pathway ... Modler AJ, Gast K, Lutsch G & Damaschun G (2003)
Assembly of amyloid protofibrils via critical oligo-
mers – a novel pathway of amyloid formation. J Mol
Biol 3...
Báo cáo khoa học: Modulation of amyloid-b aggregation and toxicity by inosose stereoisomers pot
... indication of the
amount of soluble Ab species. We measured samples
at a 48 h time point, as preliminary aggregation assays
demonstrated that approximately 60% of Ab40 and
Ab42 was pelleted at ... 2008)
doi:10.1111/j.1742-4658.2008.06321.x
Amyloid- b (Ab) aggregation and amyloid formation are key pathological
features of Alzheimer’s disease, and are considered to be two...
Tài liệu Báo cáo khoa học: Oxidation inhibits amyloid fibril formation of transthyretin ppt
... amino acids may
alter their tertiary structure contacts, and oxidation
can be used as a facile method of investigating the
Keywords
amyloid fibril; footprinting; radical probe
mass spectometry; reactive ... 90% after 1 day and 74% after
14 days. After 1 day of incubation, 60% of the unoxi-
dized V30M TTR was in the supernatant, whereas
80% of the oxidized protein was in th...
Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
... Effects of testosterone replacement
and its pharmacogenetics on physical performance and
metabolism. Asian J Androl 10, 364–372.
112 Yassin AA, Saad F & Traish A (2006) Testosterone
undecanoate ... by
increased inflammatory factors, decreased plasma TT
levels and endothelial dysfunction. Obesity is associ-
ated with decreased TT, BAT and FT levels, as well as
elevated E
2
l...
Báo cáo khoa học: Structure of amyloid b fragments in aqueous environments docx
... 511–
524.
25 Yutani K, Takayama G, Goda S, Yamagata Y, Maki
S, Namba K, Tsunasawa S & Ogasahara K (2000) The
process of amyloid- like fibril formation by methionine
aminopeptidase from a hyperthermophile, ... Mori-
kawa M, Kanaya S & Morikawa K (2001) Catalytic
center of an archaeal type 2 ribonuclease H as revealed
by X-ray crystallographic and mutational analyses.
Prot...
Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot
... PtdIns to accumulate arachidonate in the
presence of large amounts of docosahexaenoic acid and a
limited supply of arachidonic acid. As PtdIns plays an
important role as a source of signaling molecules, ... yellowtail.
Materials and methods
Materials
Yellowtails (S. quinqueradiata) were obtained from a
local market. Standard fatty acids were purchased from
Serdary Resea...
Báo cáo khoa học: Mechanisms of cholinesterase inhibition by inorganic mercury potx
... toxicologicas
de las enzimas colinesterasas. In Toxicologia Avanzada
(Repetto M, ed) pp. 117–145. Diaz de Santos SA,
Madrid.
17 Basu N, Scheuhammer AM, Rouvinen-Watt K,
Grochowina N, Klenavic K, Evans ... choli-
nesterase: its inhibition by carbamates and automatic
assay. Comp Biochem Physiol 21, 99–104.
19 Tomlinson G, Mutus B & McLennan I (1981) Activa-
tion and inactivation of...
Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx
... clearance. (B)
Depicting the pathway of de novo biogenesis of ApoE-containing HDL with the participation of the lipid transporter ABCA1 and plasma
enzyme LCAT. Minimally lipidated ApoE in plasma ... development of obesity and glucose
tolerance was assessed. Analysis of total fat content
showed that ApoE3
knock-in
mice had more total and
subcutaneous fat than ApoE4
knock-in
mic...
Báo cáo khoa học: Mechanisms of obesity and related pathologies: Transcriptional control of adipose tissue development pdf
... by a plethora of extracellular
and intracellular signaling molecules and transcription
factors that are common to both white and brown
lineages, as well as specific to a particular type of prea-
dipocyte ... under-
standing its formation and function.
Differentiation of white and brown
preadipocytes
Changes in adipose tissue mass as a result of genetic
and envir...
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