Báo cáo khoa học: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation doc

... 2006 FEBS Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation Guilhem Larigauderie 1,2,3 , Clarisse Cuaz-Pe ´ rolin 1,2,3 , ... content of macrophages was increased by overexpression of adipophilin and ⁄ or loading with VLDL. In contrast, inhibition of adipo- philin express...

Ngày tải lên: 23/03/2014, 10:21

... baseline levels by 30–45 min, depending upon the dose. The increases in serum insulin, glucose and choline induced by choline were time- and dose-dependent. Ó FEBS 2003 Choline increases serum insulin ... Turkey Intraperitoneal injection of choline (30–90 mgÆkg )1 ) produced a dose-dependent increase in serum insulin, glu- cose and choline levels in rats. The increase i...

Ngày tải lên: 17/03/2014, 09:20

... that bind to EGFR and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin (NRG) (also known as heregulin) that binds to ERBB3 and ERBB4. NRG1 and NRG2 bind to ... domain; and a C-terminal regulatory domain [2]. The extracellular domain is subdivided further into four domains. The tyrosine kinase domain consists of an N-lobe and a C-lobe, and...

Ngày tải lên: 16/02/2014, 09:20

... proteins. Thus, the MEN1 ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, ... 2010) doi:10.1111/j.1742-4658.2010.07608.x The increasing number of chromosomal rearrangements involving the human MLL gene, in combination with differences in clinical behavior and out...

Ngày tải lên: 16/02/2014, 14:20

... obtained to date indicate that inhibition of Ras activity suppresses cell proliferation and induces regression in a broad range of tumors. Intracellular antibodies, in particular single-chain ... to misfold and represent specific substrates of the UPS. In fact, targeted inhibition of the 26S proteasome increases the formation of large perinuclear scFv aggresomes and...

Ngày tải lên: 21/02/2014, 00:20

... pro- gressing lagging strand. RF2, RF3 and RF4 are the forms of the normal replication fork differing in the gap sizes of the lagging strand. The gaps in the RF2, RF3 and RF4 are 8, 4 and 0 bp, ... representation of the conserved N and I domains of some members of the RAD2 ⁄ XPG family. The total number of amino acids in each protein and homology (% identity) betwe...

Ngày tải lên: 07/03/2014, 10:20

... wild-type strain was investigated in liquid cultures. The inhibitory effect of propionate in combination with glucose was tested by use of 50 mm glucose as main carbon source and addition of different ... explained by the accumulation of propionyl-CoA from amino acid degradation (valine, isoleucine and methionine) at con- ditions of carbon starvation. In contrast, inh...

Ngày tải lên: 23/03/2014, 15:20

... reticulum, and three folded domains: an FAD- and NADPH-binding domain related to ferredoxin-NADP + reductase, a flavo- doxin-like FMN-binding domain and a connecting ÔlinkerÕ domain. In addition ... reduc- tion in rate of interflavin electron transfer in NADH- reduced CPR thus suggests a role for coenzyme binding, and in particular for interactions made by the 2¢-phosphate...

Ngày tải lên: 23/03/2014, 17:22

... positioning of the imidazole side chain of H260 #381 adjacent and hydrogen-bonded to the ring C nitrogen in 1ZTU; (b) the role of B ⁄ C ring nitrogen protona- tion in electronic coupling [36]; and ... His6-tagged apoproteins in E. coli, purified and tested for PCB-binding, apopro- tein folding, Pr–Pfr photochromicity and thermal reversion using SDS ⁄ PAGE ⁄ zinc fluorescence...

Ngày tải lên: 30/03/2014, 11:20

... our model by verifying that it in- deed correctly predicts human judgements, and by comparing its performance with that of a standard role labeller in terms of both judgement prediction and role ... com- binations of verbs and arguments are still mostly unseen in training for all data sets. We describe two complementary approaches to smoothing sparse training data. One...

Ngày tải lên: 31/03/2014, 20:20