Báo cáo khoa học: Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes potx
Báo cáo khoa học: Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes potx
... mole-
cules of biological significance [1,6–15], including
antitumor cis-diamminedichloroplatinum(II) (cisplatin)
(Fig. 1B) and its clinically ineffective trans isomer [16].
The bifunctional platinum complexes, ... high sensitivity of
DNase I to DNA conformational alterations induced by platinum com-
plexes so that the platinum adducts which induce specific local conforma-
tion...
Tài liệu Báo cáo khoa học: Molecular cloning, recombinant expression and IgE-binding epitope of x-5 gliadin, a major allergen in wheat-dependent exercise-induced anaphylaxis ppt
... recombinant x-5 gliadin protein that
can be used for diagnosis and possibly treatment of
WDEIA.
Results
Identification of IgE -binding epitopes in
x-5 gliadin
The IgE -binding epitopes of x-5 gliadin ... patients.
The binding of IgE to nOG5 was completely inhibited
by increasing amounts of rOG5C in all patients. At an
inhibitor concentration of 0.1 and 1 lgÆmL
)1
, nOG5
inhibit...
Báo cáo khoa học: Human telomeric G-quadruplex: thermodynamic and kinetic studies of telomeric quadruplex stability potx
... that
folding of G-rich oligonucleotides into quadruplex
structures proceeds via kinetically significant interme-
diates. These intermediates may consist of antiparallel
double hairpins in rapid equilibrium ... Coupling of local
folding to site-specific binding of proteins to DNA.
Science 263, 777–784.
50 Lane AN & Jenkins TC (2000) Thermodynamics of
nucleic acids and their int...
Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx
... the
aromatic pyrimidine ring and the indole group of
Trp27 should to be weaker in comparison with the
purinetrione inhibitors due to the smaller size of the
pyrimidine ring. It has in addition resulted ... active
site with an inhibitor molecule of proper size, shape
and atomic composition clearly stabilizes the interac-
tion of the subunits within the pentamer. This conclu-
sion is in...
Báo cáo khoa học: D-Amino acids in the brain: the biochemistry of brain serine racemase potx
... was
established with its N-terminal 66 residues. Binding of
Golga3 increases d-serine synthesis. Intriguingly, this is
achieved through a decrease in ubiquitin ⁄ proteasomal
degradation of serine racemase, ... of calcium, it is possible that some other
GRIP-interacting protein that also binds to PDZ6
might disrupt the serine racemase–GRIP interaction,
hence diminishing the activity o...
Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf
... its 72 kDa progelatinase complex.
Demonstration of the biochemical similarities of tissue
inhibitor of metalloproteinases-2 and tissue inhibitor of
metalloproteinases-1. Biochem J 278, 179–187.
16 ... cysteine-
rich protein with kazal motifs (RECK) is a cell mem-
brane associated inhibitor of MMP-2 that is able to
inhibit the second activation step of MMP-2 [9].
The small calcium...
Tài liệu Báo cáo khoa học: Type I antifreeze proteins expressed in snailfish skin are identical to their plasma counterparts doc
... all fish
examined had significant levels of protein in blood and
skin during the winter. It is possible that different phy-
siological or environmental cues initiate expression in
each tissue separately. ... as important for ice binding [21–23]. Recently,
amino acid substitution experiments have determined
that it is the conserved Ala-rich hydrophobic surface
which is most important for i...
Báo cáo khoa học: A study on genomic distribution and sequence features of human long inverted repeats reveals species-specific intronic inverted repeats pptx
... expression. The
stem-loops and palindromes constructed by inverted
repeats are involved in RNA interference, transcription
initiation of genes, initiation of DNA replication and
alternative splicing ... cruciforms: significance for initiation of
DNA replication. J Cell Biochem 63, 1–22.
25 McAlinden A, Havlioglu N, Liang L, Davies SR &
Sandell LJ (2005) Alternative splicing of...
Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf
... gene families in rice. In this study, whole genome microarray
analysis of auxin-responsive genes in rice was performed, with the aim of
gaining some insight into the mechanism of auxin action. A ... positively regulate
the expression of downstream genes involved in auxin
signaling. The differential and overlapping expression
patterns of individual members of these gene families
in...
Báo cáo khoa học: Modular kinetic analysis reveals differences in Cd2+ and Cu2+ ion-induced impairment of oxidative phosphorylation in liver pot
... compilation ª 2009 FEBS
Metal-induced impairment of mitochondrial function J. Ciapaite et al.
Modular kinetic analysis reveals differences in Cd
2+
and
Cu
2+
ion-induced impairment of oxidative ... quantification of microgram quantities of protein
utilizing the principle of protein–dye binding. Anal
Biochem 72, 248–254.
40 Ciapaite J, Van Eikenhorst G, Bakker SJ, Diamant M,
Heine...