Báo cáo khoa học: Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon doc
Báo cáo khoa học: Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon doc
... of 35 S-labeled proteoglycans from the matrix of tendon explants. The rate of incorporation of [ 3 H]serine into proteins of tendon explant cultures was measured on days 5 and 10 of the culture period in the ... presence of heparin, the catabolism of 35 S-labeled proteoglycans in these cultures was also inhibited. By day 10 of the culture pe...
Ngày tải lên: 23/03/2014, 10:21
Tài liệu Báo cáo khoa học: Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells docx
... to the cytosolic compartments, while the proportion of Fe incor- porated into ferritin remained within the range obtained for the control (Table 3). The changes in the cellular distribution of ... 2), with a big increase in the proportion of Fe in the cytosol suggest that all the chelators including DFO and DFP, act in part intracellularly, mobilizing Fe from...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter docx
... containing the 1G probe appear unchanged in the presence of the inhibitor (–). Thus, a decrease in the expression of MMP-1 in the presence of PD098059 may be due, at least in part, to a decrease in ... with increasing concentrations of PD098059 results in a decrease in the intensity and/ or a complete disappearance of some bands, indicated by arrows. In...
Ngày tải lên: 21/02/2014, 00:20
Báo cáo khoa học: Aspartate transcarbamylase from the hyperthermophilic archaeonPyrococcus abyssi Insights into cooperative and allosteric mechanisms docx
... kDa) and bovine serum albumin (67 kDa) were deter- mined. A standard curve was made with the logarithm of the molecular mass of the proteins in the y-axis and the elu- tion volumes (V e ) in the ... 25% inhibition (Fig. 9). Increasing the UTP concentration from 0 to 5mm resulted in 50% inhibition of the enzyme, the maximal inhibition caused by UTP alone (Fig....
Ngày tải lên: 16/03/2014, 19:20
Báo cáo khoa học: Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A docx
... dodecapeptides covering resi- dues 156–466 of the prey protein were synthesized on A B Fig. 1. Identification of GRINL1A as a DYNLL1-interacting protein and fine map- ping of the binding site. (A) Using a yeast two-hybrid ... Stabilizing salt- bridge interactions are found between the carboxylate group of E422 and the amine groups of K43 and K44 of monomer B, and th...
Ngày tải lên: 29/03/2014, 09:20
Báo cáo khoa học: An ‘Old World’ scorpion b-toxin that recognizes both insect and mammalian sodium channels A possible link towards diversification of b-toxins ppt
... concentration of the radiolabeled toxin was determined according to the specific activity of the 125 I corresponding to 2500–3000 d.p.m.Æfmol )1 of monoiodotoxin, depending on the age of the radiotoxin and ... similar to the anti-insect depressant toxin, LqhIT2, in its toxic symptoms induced in blowfly larvae, and the ability to compete for the binding site of...
Ngày tải lên: 31/03/2014, 01:20
Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc
... with the inhibition of the antiproliferative activity of ATP by the MEK1 ⁄ 2 inhibitors PD98059 and UO126 and the p38 MAPK inhibitor SB20358 (Table 1). The differences in the phosphorylation of ERK1 ... pro- tein kinase (MAPK), protein kinase C and PI3 kinase. All values are means ± SD of 3–6 independent experiments run in triplicate. (A) Signaling pathway inhibi...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: "Medical treatment for the terminally ill: the ‘risk of unacceptable badness’"
... much turmoil regarding the ‘life is sacred at any cost’ maxim [1]. Current technology is capable of indiscriminately maintaining some of the vital functions of the body, but the same technology ... of diminishing returns. However, there is a continuing trend of surrogates demanding that moribund patients be kept on life support after prevailing medical opinions concur that t...
Ngày tải lên: 25/10/2012, 10:45
Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf
... at higher levels in testes than ovaries. The deep interest in Dmrt1 in the field of sex deter- mination in fish came with the discovery of a dmrt1 homologue on the Y chromosome of the fish medaka (Oryzias ... of Sry is translated into cellular structure and organ morphology. Interestingly, Dmrt1, the ancestor of Dmrt1bY, is one of the downstream effec- tors o...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx
... still largely unknown. The aim of the current study was to investigate the potential involvement of nucleolin ⁄ C23 in the antiapoptotic mechanism of Hsp70. We found that primary cultures of neonatal ... 1C). Increased nucleolin/C23 protein levels in Hsp70-transfected cells in response to H 2 O 2 -induced apoptosis We next examined the expression of nucleolin ⁄ C23...
Ngày tải lên: 16/02/2014, 09:20