Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... Direct CIII HflB interaction is responsible for the
inhibition of the HflB (FtsH)-mediated proteolysis
of Escherichia coli r
32
by kCIII
Sabyasachi Halder
1
, Subhamoy ... the
absence of CIII, CII is rapidly degraded by the ATP-
dependent host metalloprotease HflB (FtsH). The
molecular mechanism for CIII-mediated inhibition of
the pro...
Báo cáo khoa học: A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis doc
... with the protein
kinase C theta isoform [27]. Transient expression of
Grx3 positively regulates calcineurin–NFAT activation
in rat basophilic leukemia cells (RBL-2H3) [33]. Fur-
thermore, forced ... deletion of
Grx3 did not alter the G
1
⁄ S phase progression.
A
B
C
D
EF
Fig. 4. Disruption of Grx3 in mice. (A) Shown is the schematic dia-
gram of MmGrx3 genomic DNA structure an...
Báo cáo khoa học: TioS T-TE – a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides potx
... in their natural
habitat. Among such compounds, the class of biologi-
cally active peptides represents a rich resource for the
discovery of novel pharmaceutical agents. The biosyn-
thesis of the ... Encouraged by the results obtained,
and to investigate the mechanism of macrocyclization,
the steric demand of the C-terminal amino acid was
further increased by t...
Tài liệu Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells doc
... death [27]. The functional
roles of the activation of these kinases are often con-
troversially discussed. The ERK1 ⁄ 2 cascade is
regarded to be the main method of transmission for
cell proliferative ... that
the anti-apoptotic function of NF-jB activation might
consist of the promotion or repression of autophagy,
depending on whether autophagy is a survival or...
Tài liệu Báo cáo khoa học: Direct identification of hydrophobins and their processing in Trichoderma using intact-cell MALDI-TOF MS docx
... 841
mechanism of mycoparasitism as well as the coloniza-
tion of decaying wood.
Our information about the roles of hydrophobins
in the physiology of Trichoderma, as well as in other
fungi, is mostly ... conditions,
different strains of this taxon displayed different MS
fingerprints. Because of the ease and speed of the
analysis, we investigated whether the hydrophob...
Tài liệu Báo cáo khoa học: "Direct Word Sense Matching for Lexical Substitution" ppt
... which could play the role of the source
word (that is, 41% of the synsets consisted of the
target word only). Similarly, 62% of the test exam-
ples of the target words were annotated by a synset
that ... in
this multi-class setting it is less straightforward to
tradeoff recall for precision, as all senses compete
with each other.
Direct. In the direct supervi...
Báo cáo khoa học: Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic b-islets ppt
... in other metabolically relevant tissues [11,12].
In this study, we have further investigated the role
of mirs in the control of insulin secretion. We report
that the 3¢UTR of Sirt1 mRNA is targeted ... response to glucose chal-
lenge (GSIS). These reports strongly suggest a role for
Sirt1 in the regulation of insulin secretion. In spite of
this, it is not known whether...
Báo cáo khóa học: Direct electrochemistry of the Desulfovibrio gigas aldehyde oxidoreductase docx
... This is not surprising for the
values obtained at both the PGE and GCE for the
diffusionless process. The difference in the response
stability reported at the carbon electrodes is related to
the ... and in the presence of neomycin, the redox
reaction observed is due to the reduction of the Mo atom of
the molybdopterin cofactor. Indeed, although the mo...
Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
... intracellular trafficking of NCT.
Effect of Synoviolin on the production of Ab
NCT is one of the essential cofactors of the c-secretase
complex. We therefore investigated the effect of the
Synoviolin-mediated ... most
likely that the accumulation of NCT in synoviolin-null
cells is a result of the suppression of the degradation
of NCT. To further investig...
Báo cáo khoa học: Direct interaction between CD91 and C1q docx
... analyzed by
SPR analysis, using the latter proteins as soluble
ligands. In the case of the globular domain, the two-
state binding model also provided the best fit. More-
over, the affinity of the interaction ... of calreticulin. The CD91–C1q interaction
showed all of the signs for being specific because the
interaction was time- and concentration-dependent....