Báo cáo khoa học: Metabolic pathway that produces essential

Báo cáo khoa học: Metabolic pathway that produces essential fatty acids from polymethylene-interrupted polyunsaturated fatty acids in animal cells pot

... acid. Involvement of peroxisomal b-oxidation in the chain shortening of C 20 PMI-PUFAs It is known that peroxisomal b-oxidation of long-chain fatty acids in animals results in chain shortening ... acid are converted into linoleic acid and a-linolenic acid, respectively, in animal cells. This metabolic pathway can be regarded as a way to produce essential fatty acids...

Ngày tải lên : 23/03/2014, 09:20

10
234
0

Báo cáo khoa học: Characterization and cDNA cloning of a cloﬁbrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster potx

... signify amino acids identical among all three proteins; dots indicate amino acids identical between two proteins. The small box indicates the position of substituted amino acids within the mEH catalytic ... laminarin was produced via a mechanism different from that of cloﬁbrate. Discussion We demonstrated that mEH activity was induced by cloﬁbrate in D. melanogaster to a level s...

Ngày tải lên : 07/03/2014, 21:20

10
378
0

Báo cáo khoa học: Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells pdf

... pathways, the ERK1 ⁄ 2 and c-Jun N-terminal kinase pathways, through AP-1 signaling [26]. AP-1 family proteins are good candidates for mediating NGF-induced miR-221 ⁄ 222 expression in PC12 cells. A ... conﬁrmed inhibition of protein synthesis by monitoring expression of c-Fos protein, which is a Fig. 2. Activation of ERK1 ⁄ 2 pathway is involved in miR-221 ⁄ 222 induction. (A, B) PC1...

Ngày tải lên : 16/03/2014, 01:20

8
334
0

Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx

... some interesting ﬁndings along these lines as discussed below. Signaling by Itk in i NKT cells Itk plays a critical role in the increase in intracellular calcium in T cells, in part by interacting ... signal-regulated kinase; Id3, inhibitor of DNA binding 3; IFN, interferon; IL, interleukin; i NKT, invariant natural killer T cells; Itk, interlukin-2 inducible T-cell kinase; MAPK...

Ngày tải lên : 28/03/2014, 22:21

10
454
0

Báo cáo khoa học: Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential doc

... non-P-glycoprotein-containing cells and the same cells transfected in such a way that they express this protein. We demonstrated that in cells that do not contain P-glycoprotein, neither CsA, ... analogs in GLC4 cells. Inhibition of P-glycoprotein by CsA and its analogs, including NIM811, resulted in signiﬁcant increases in JC-1 ﬂuor- escence as compared to GLC4 ⁄ P-gly...

Ngày tải lên : 30/03/2014, 08:20

10
455
0

Báo cáo khoa học: Metabolic fate of L-lactaldehyde derived from an alternative L-rhamnose pathway ppt

... ALDHs in the A. vinelandii genome, indicating that the protein may function as LADH (referred to as AvLADH). Two active bands corresponding to NAD + -dependent LADH were found in Zymogram staining ... This indicates that, although the glutamate residue in PsLADH (and fungal ALDHs) should play a role in coenzyme binding and ⁄ or structural maintenance, other amino acid residues ma...

Ngày tải lên : 30/03/2014, 02:20

11
533
0

Tài liệu Báo cáo khoa học: Functional characterization of an orphan cupin protein from Burkholderia xenovorans reveals a mononuclear nonheme Fe2+-dependent oxygenase that cleaves b-diketones ppt

... ligands. Note that the coordinating histidines are contributed from b-strands of the central cupin barrel, suggesting a rather rigid metal-binding site. Residues in the immedi- ate vicinity of the ... measuring the increase in absorbance at 550 nm resulting from cyto- chrome c being reduced by superoxide in the course of the reaction. The principle of the assay is that the prese...

Ngày tải lên : 18/02/2014, 06:20

15
624
0

Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf

... underlying increased cardioprotection in younger female mice are unclear. We hypothesized that serine-threonine protein kinase (protein kinase B; Akt) triggers a metabolic gene switch (decreased fatty acids, ... nuclear regulators of numerous fatty acid metabolic genes [10]. In light of this, we hypothesized that Akt triggers a metabolic gene switch from fatty acids...

Ngày tải lên : 18/02/2014, 16:20

7
582
0

Tài liệu Báo cáo khoa học: Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects Implications for a mechanism linking obesity and type 2 diabetes pdf

... Turku, Finland). ATP concentrations in the medium and the mitochondrial matrix were determined from yeast hexokinase kinetics as described [16]. As hexokinase kinetics were determined in medium ... nucleotide from its binding site on the protein [8]. It has been hypothesized that increased concentrations of free LCACs interfere with mitochondrial function through inhibition of t...

Ngày tải lên : 19/02/2014, 05:20

15
546
0

Tài liệu Báo cáo khoa học: Metabolic ﬂux proﬁling of Escherichia coli mutants in central carbon metabolism using GC-MS docx

... histidine, isoleucine, leucine, phenylalanine, proline, serine, threonine, tyrosine, and valine for [U- 13 C]glucose experiments and aspartate, isoleucine, leucine, phenylalanine, serine, ... attained assuming that the remaining glycine fraction with two independent C atoms originates from CO 2 and a one carbon unit through the reversible glycine cleavage pathway or through threonin...

Ngày tải lên : 20/02/2014, 23:20

12
421
0