Báo cáo khoa học: Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization pptx
Báo cáo khoa học: Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization pptx
... arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization Tsui-Yi ... translation inhibitory activity and subcellular localization. Results Phosphorylation of the RS-rich motif of the SARS-CoV N protein Coronavirus N proteins are phosphoproteins [30,32]. The N protein of ... as those of the SR protein kinase(SRPK) and Clk families [28]. Phosphorylation of the RS domain modulates the activity, protein protein interactions and subcellular localization of SR proteins[29]....
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Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
... Bud32p-depen-dent phosphorylation of other subunits of the complexcould directly regulate its activity. In addition to the components of the EKC ⁄ KEOPScomplex, many other proteins have been ... elongation. We have then examined the effects of Ser258 phosphorylation of Bud32p on the transcriptional activity of the EKC ⁄ KEOPS com-plex by analyzing the activation rate of the galactose-inducible ... Bud32p phosphorylation state and finely tuning its functions. These results highlight for the first timeBud32p as a substrate of Sch9p and probably one of the effectors of this crucial protein...
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Báo cáo khoa học: Phosphorylation modulates the local conformation and self-aggregation ability of a peptide from the fourth tau microtubule-binding repeat pdf
... atneutral pH, affects the electrostatic potential and quite often the conformation of the modified protein. Even in the absence of rearrangement, the changein the electric field and steric hindrance ... tubulin-binding motif might offer some clueson its role in the progression of AD. The modulation of phosphorylation on aggregation might be essentialfor the aggregation of tau protein in vivo. The peptideconcentration ... pKa1 and pKa2. The pKavalue is deter-mined from a fit of the phosphorus chemical shifts of the without ionic, monoionic and diionic forms of the phosphate group as a function of pH [33,34]. The phosphorus...
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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... 3–4), the phosphorylation was much weakerthan that detected at 37 °C, supporting the idea thatendocytosis of the receptor/ligand complex is important for the phosphorylation of Hrs. Nevertheless, ... thoughHrs was identified as a phosphorylated protein, neither the responsible kinase(s), the exact phosphorylation site(s) nor the functional significance of the phosphorylation have beenidentified so ... lackSrc, Yes and Fyn The previous results led us to suspect that Src plays animportant role in the phosphorylation of Hrs. Therefore, wewanted to examine whether EGF-induced phosphorylation of Hrs...
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Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"
... 22-beddedgeneral ICU. The sampling periods were 28 weeks before and 2, 10, 25 and 37 weeks after introduction of CPOE. The unitpharmacist prospectively recorded details of MEs and the totalnumber of drugs ... committee. Prior tointroduction of CPOE, local standards of prescribing existedspecifying the tenets of good practice, including the avoid-ance of the use of abbreviations.An ME was defined ... (where the patient received the drug). The intercepted errors were scored separately on the basis of their possible impact on the patient, if the prescriptionhad been administered as prescribed.The...
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Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx
... composed of a hOrn and a haOrn moiety.Furthermore, a long-range1H–13C correlation wasdetected between the carbonyl carbon of the serine and the d-CH2 of the hOrn, which constitutes the DKP.Therefore, ... characterization of these compounds isgrowing and may result in the synthesis of specificinhibitors based on the structure of the pathogensiderophore [16].A promising approach for the isolation of secondarymetabolites, ... MbtH-like protein (etcE) and proteins for siderophore export and uptake (etcCFGK).A bioinformatic overview of the encoded proteins and the corresponding functions is provided in Table S1. The amino...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... to study the binding of ATP alone to the protein were unsuccessful,as the protein precipitated upon addition of ATP in the absence of pantoate. An important feature of the NMR study is the fact ... molecule takes the position of the adenine ring of ATP. The carbon and oxygen atoms of pantoate are shown inyellow and red, respectively. The carbon and oxygen atoms of ATP are shown in red, the nitrogen ... from low amounts of pantoate [9]. Here, wereport the results of the structural studies of the panto-ate-bound form of the N-terminal domain of E. coliPS (nPS). The structure and substrate-binding...
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Tài liệu Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area ppt
... to the relatively largenumber of studies devoted to the elucidation of the phosphorylation sites in HSL and the regulation of its translocation, few studies have addressed the effects of PKA phosphorylation ... to LPL in the vicinity of the active site and also to inhibit the enzymatic activity [12]. Simi-larly, we show here that bis-ANS inhibits the lipase activity of HSL. Interestingly, there were ... concentrations of the hydro-phobic probe bis-ANS, using TO as substrate. The activity of phos-phorylated HSL in the TO assay was normalized to the activities of nonphosphorylated HSL, and the activities...
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Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf
... a molecular mass of 16 309.7 Da, butthis matched none of the DNA-predicted proteins.MS ⁄ MS of these ions gave the C-terminal sequence of Fig. 5. These and all other peaks of that spectrum ... acceptedfor the routine identification of proteins in complexmixtures. Usually, the identification of the gene thatencodes the protein is more important than full struc-tural characterization of the protein. ... proteolysis destroys the information on the size of the protein and the connectivities of the pep-tide fragments, but it has no size limit for protein digestion. In contrast, the top-down approach...
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Tài liệu Báo cáo khoa học: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases pptx
... and foundthat the cellular phosphorylation of CDK4 on Y17 ismediated by Src family kinases.ResultsDetection of CDK4 Y17 phosphorylation and kinase activity The N-termini of CDKs 1, 2, 4 and ... the appearance of kinase activity inthose samples. The level of depletion of kinase activity mirrored the level of depletion of C-YES, indicatingthat C-YES contributes a large fraction of the ... pathway [7], and a better understanding of howCDK4 ⁄ cyclin D kinase is controlled could provide newtherapeutic targets and strategies for the treatment of cancer. The activity of the CDK4 ⁄...
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