Báo cáo khoa học: An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase b2 mRNA translation potx
Báo cáo khoa học: An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase b2 mRNA translation potx
... bothtranscription and scanning translation. It also suggeststhat the initiation of sGC b2 translation is through an alternative mechanism that is less efficient than scan-ning translation. The ... 2008)doi:10.1111/j.1742-4658.2008.06505.x The soluble guanylyl cyclases (sGC), the receptor for nitric oxide, are hete-rodimers consisting of an a- and b-subunit. This study aimed to investigate the translational mechanism of the ... translationalmechanism of the sGC b2- subunit. We found thatsGC b2 translation is mediated by an IRES. This is the first example of an IRES being identified in one of the sGC genes.ResultsCloning of the sGC b25 ¢-UTRsThe...
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Tài liệu Báo cáo khoa học: An engineered disulfide bridge mimics the effect of calcium to protect neutral protease against local unfolding docx
... Model of the 3D structure of the neutral protease from Bacillus stearothermo-philus, including the position of the disulfidebridge in mutant G8C ⁄ N60C. The modelwas created on the basis of the ... kB, h and R as Boltzmann’s constant, Planck’sconstant and gas constant, respectively, and T andDG#as absolute temperature and Gibbs free energy of activation, respectively, the DG# of unfolding ... kinetics of the pseudo-wild type (pWT) neutralprotease from Bacillus stearothermophilus, of the disulfide bondmutant G8C ⁄ N60C, and of the protease variant W55F, in the pres-ence of 7.25M guanidine...
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Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx
... similar in the fractions in the periphery [20].In the absence of Itk, there are reduced numbers of iNKT cells in the thymus and periphery [21]. Moredetailed analysis of the development of Itk-nulli ... including the sec-ondary lymphoid organs and the epithelial layers of tissue such as the skin, intestinal epithelium and lung. The different subsets of cd T cells express distinct cdTCRs and develop ... andIFN-c, they lack the capacity to translate and secretethese cytokines upon antigenic stimulation bothin vitro and in vivo [20,22,25]. By contrast, bypassing the TCR with the addition of 4b-phorbol...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... reflect the energy sta-tus of the animal. These nutrients too can provokechanges in feeding behavior and energy expenditure.For example, the hypothalamus can sense and respondto fluctuations in the ... lipid nutrient sensing in the brain and is an example of an enzyme that can senseand respond to the nutritional environment. The majorchallenge to understanding the role of CPT1c is todetermine ... rodents[21]; (d) changes in malonyl-CoA level in the hypothal-amus correlate closely and rapidly with reciprocalchanges in the levels of the orexigenic and anorecticneuropeptide expression in the hypothalamus...
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Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... interval, there are six types of serial-order process that can occur and affect the state of the process. The most important aspect of the control is that all of the serial order computations can ... mathematically better defined than through other methods, because it enables one to develop a broader perspective of the questions within an analysis of the hypothesis in the con- text of ... both the change in state that results over time and "how" the change occurred. Analyzing both aspects of the process is the focus of comparison between "normal" and "lesion"...
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Tài liệu Báo cáo khoa học: "Language Resources Factory: case study on the acquisition of Translation Memories" potx
... robust (i.e. makesuse of retry and parallelisation) and the error isconfined to a WS (i.e. it does not affect the rest of the workflow). An instance of Biocatalogue and one of my-Experiment have ... On the other hand, GrAFcan be used as a pivot format between other for-mats (Ide and Bunt, 2010), e.g. there is softwareto convert GrAF to UIMA and GATE formats (Ideand Suderman, 2009) and ... al., 2012).Another aspect of the factory that is being eval-uated is its performance and scalabilty. They donot depend on the factory itself but on the design of the workflows and WSs. WSPs...
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Báo cáo khoa học: A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin pot
... LC-MS ⁄ MS analysis. Of 22(17 nonredundant) candidate substrates identified, the proteolytic process-ing of vinculin, lysyl oxidase, collagen type V and annexin A1 was analysedby means of immunoblotting ... PAGE-based image analyses of the third quadrant.Fig. S3. 2D IEF ⁄ SDS ⁄ PAGE-based image analyses of the fourth quadrant.This supplementary material can be found in the online version of this article.Please ... level 1 match-sets are the reference gels of the respective quadrants from the 2D gel sections of eachcondition and the four higher-level match-sets are the reference gels of the two different conditions...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
... from the other bran-ches, which was indeed predicted. The other maingroup, obtained 97% of the time in 20 740 exploredtrees, contained the DIDO PHD sequences clusteredwith the PHF and the ... yeast and other organisms. These homologues have a rolein DNA regulation and chromatin stability, and form part of higher com-plexes linked to active chromatin. Further domain composition analysesperformed ... conserved among the sequences and always follows the PHD domain.Using PSI-BLAST, the dPHD of DIDO1 hits CGBP_MOUSE at the second iteration, with an e-value of 2e-06 (inclusion threshold of 0.03)....
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Báo cáo khoa học: cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells pdf
... feature in the regulation of cholesterol transport by AA and the release of AA in a specialized compartment of the cells could offer novel means for understanding the regulation of steroid synthesis, ... through the CPT1-dependent pathway. The specificity of this mechanismto release AA inside the mitochondria is shown by the fact that the content of labeled AA in another organ-elle such as the ... that the role of DBI is to facilitate the transport of fatty acids through the mitochondrial outer membrane. The homologybetween the DBI and an acyl-CoA binding protein cer-tainly enhances...
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Báo cáo khoa học: A novel retinol-binding protein in the retina of the swallowtail butterfly, Papilio xuthus docx
... upstream from the start of the poly(A)+tail.Fig. 2. HPLC analysis of the intrinsic ligand of Papi lio RBP. The lig-ands were extracted from Papilio RBP purified from the soluble fraction of the dark-adapted ... the stained bands using a Sharp JX-350 image scanner. Wefurther analyzed the isomer composition of the intrinsicligands of Papilio RBP extracted separately from the distaland proximal portions of the ... increases the 11-cis isomer of the ligand and inducesredistribution of the Papilio RBP from the proximal to the distal part of the photoreceptor layer. These results suggestthat the Papilio...
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