Báo cáo khoa học: Paralog of the formylglycine-generating enzyme – retention in the endoplasmic reticulum by canonical and noncanonical signals pptx

... (PGEL in human), split into the variable posi- tions 1 and 2, and the conserved EL ⁄ DL in positions 3 and 4. Species with canonical retention signals are colored in blue, and noncanonical signals in ... noncanonical retention signals S. L. Gande et al. 1130 FEBS Journal 275 (2008) 111 8–1 130 ª 2008 The Authors Journal compilation ª 2008 FEBS Paralog...

Ngày tải lên: 23/03/2014, 07:20

... helix–span–helix domain at the C-terminus shown in blue medi- ates dimerization and, together with the basic domain, (red) DNA-binding. ‘*’, amino acids that are identical in all sequences in the ... helix–span–helix DNA-binding and dimerization domain at their C-terminus, and a less conserved proline-rich and glutamine-rich transactiva- tion domain at their N-terminus [ 8...

Ngày tải lên: 16/02/2014, 09:20

... receptor-blocking experiments. The rates of uptake of both the lipid and protein components are not matched by the rate of cel- lular metabolism of these species, resulting in the accu- mulation of both unmodified ... and glycated apoB in the cells. The rate of removal of the latter species is slow, with only 2 0–3 0% of the glycated protein being de...

Ngày tải lên: 19/02/2014, 02:20

... 17.6 Fig. 5. Insertion of stefins into DOPC and DOPG monolayers. (A) Kinetic traces of the insertion into DOPG lipid monolayers at initial pressure of 5 mNÆm )1 . The proteins were injected into the sub- phase ... signal increase during the injec- tion phase was the largest and there was low dissoci- ation after the end of injection. Discussion The main hypothesis for...

Ngày tải lên: 07/03/2014, 17:20

... similar position as the lowest faint band observed for wild-type Kv3.1 and the lower faint band of the single mutants, and furthermore, the immuno- band did not shift in the presence of TM. To verify that ... utilized in rat brain and infected Sf9 cells, and the role that occupancy of these sites has in the expression of functional Kv3.1s at the cell surf...

Ngày tải lên: 16/03/2014, 13:20

... receptors, including human RXR (which is the ortholog of USP) have shown that an area on the surface of the ligand binding domain involving the C-terminus of a-helix 3, a-helix 4, and the N-terminus of ... activation by JH III by way of binding of JH III or closely related structures to the ligand binding pocket of USP [18]. This binding of JH III by USP in...

Ngày tải lên: 23/03/2014, 13:20

... shown). The basic cluster of amino acids in the binding groove of 14-3-3, including amino acids Lys-49, Arg- 56, Lys-120 and Arg-127, in an otherwise acidic mole- cule, are important for the interaction ... Petri dishes and incubated with medium contain- ing penicillin, streptomycin and gentamicin to ascertain the reversibility of this cytotoxic response (E–H). L. Yasm...

Ngày tải lên: 19/02/2014, 08:20

... traces of animals in the first two weeks of lactation. The fraction containing eugenin is indicated by an asterisk in Fig. 2. Two further HPLC separations of the initial eugenin frac- tion (1 0–7 5% ... as stimulation of the proliferation of lymphocytes, activa- tion of CCK receptors stimulate production of inter- leukins and secretion of immunoglobulins on t...

Ngày tải lên: 19/02/2014, 16:20

... DvHc 3 causing narrower NMR signals and perturbing the chemical shifts of the haem methyl sig- nals in intermediate redox stages. The contraction of the line widths of the NMR signals in intermediate redox ... obtained for DvHc 3 :ZnRb and DvHc 3 is also reported in Fig. 4 and indicated by continuous and dashed lines, respectively. The figure shows that t...

Ngày tải lên: 19/02/2014, 17:20

... We initialize the sampler by randomly as- signing each string in the training corpus a random tree generated by the grammar. Then we randomly select a string to resample, and sample a parse of ... grammar, in which the subtrees are specified in advance, in an adaptor grammar the subtrees, as well as their probabilities, are learnt from the train- ing data. In orde...

Ngày tải lên: 20/02/2014, 09:20