Báo cáo khoa học: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand pdf
Báo cáo khoa học: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand pdf
... Asn73 of BMP -6 in the wrist epitope is crucial for recognition by the activin receptor type I. In the absence of the carbohydrate moiety, activin receptor type I- mediated signaling of BMP -6 is totally ... totally diminished. Thus, flexibility within the binding epitope of BMP -6 and an unusual recognition motif, i. e. an N-glycosylation motif, possiblyplay an important role in type I receptor specificity ... possible altera-tions of the type I receptor- binding profile were inves-tigated. Comparison of the receptor binding of Escherichia coli and CHO-cell derived BMP -6 reveals the importance of N-glycosylation...
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Tài liệu Báo cáo khoa học: Type I antifreeze proteins expressed in snailfish skin are identical to their plasma counterparts doc
... in that they do notappear to contain a signal sequence or pro-sequences [6 8].Surprisingly, the amino acid composition of proteinspurified from Atlantic snailfish skin tissue is quite sim-ilar ... snailfish contradicts the ABCDFig. 4. Distribution of type I AFP mRNA in skin and liver tissuesfrom Atlantic and dusky snailfish. (A) Northern blot analysis of skintissue RNA from four individual ... proteins that are identical to circulating plasmaAFPs. Although all fish examined consistently express antifreeze mRNA inskin tissue, there is extreme individual variation in liver expression...
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Báo cáo khoa học: Estrogen-related receptor a and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondria potx
... organism to adapt to its fluctuating nutri-tional status or to varying environmental conditions.However, the identification of the key factors of mito-chondrial biogenesis in the context of proliferatingcells ... oxygen consumption following the inhibition of ERRa confirmed the effect of this factor on the mitochondrial respiratory chain. Inhibition of both members of the ERRa–PRC complex decreased the cellular ... mitochondrial respiratorychain, independent of COX and CS activities.DiscussionMitochondria contribute to the generation of energythrough oxidative phosphorylation. The biogenesis of ABFig. 3. The ERRa–PRC...
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Báo cáo khoa học: Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes potx
... of con-ventional mononuclear cis-diamminedichloroplatinum(II) (cisplatin). Theseexaminations took into account the fact that the local conformation of the DNA at the sites of the contacts of ... thisadditional protection in the duplex 1,4-IEC in the 5¢)5¢ direction is more extensive (Fig. 6) . The latteradditional protection is observed for two sites on the 3¢ side of the platinated guanine ... thymidines on the 3¢ side of the adduct in the top strand is a unique and interestingobservation for the 1,3-intrastrand CL of BBR3 464 (Fig. 2). It is quite plausible that the formation of the 1,3-intrastrand...
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Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf
... G(1991) The purification of tissue inhibitor of metallo-proteinases-2 from its 72 kDa progelatinase complex.Demonstration of the biochemical similarities of tissueinhibitor of metalloproteinases-2 ... know the role of individual MMPs, their expression pattern andactivation mechanisms. The best-described activationmechanism for MMP-2 is the two-step cell-surfaceactivation in which proMMP-2 is ... identification of the in vivo substrates of individual MMPs. It is thus important to discover howeach ECM component in the microenvironment of agiven cancer type affects expression and activation...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... mediated via two distinct sig-naling pathways. The first is enhanced Ca2+mobilization by the inositol1,4,5-trisphosphate receptors due to inhibition of protein kinase A. The second pathway concerns ... PI3-Kcspecific inhibitor, AS252424, antagonized the P2Y12- dependent part of the Ca2+response, indicating thatPI3-Kß is the main isoform in Ca2+signal modulationvia P2Y12. Examination of targets ... 4A). In marked contrast, preincubation with the PI3-K inhibitor wortmannin was ineffective.Further experiments confirmed the sensitivity of InsP3-induced Ca2+mobilization for modulation of PKA...
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Tài liệu Báo cáo khoa học: Specific membrane binding of the carboxypeptidase Y inhibitor IC, a phosphatidylethanolamine-binding protein family member doc
... CPY -binding sites participates inregulation of the specific binding of I Cto the anionicphospholipid membranes (Fig. 4A). The participation of the N-terminal region of bovine PEBP in its mem-brane ... mutational studies on the membrane binding of I Cand the disposition of the I Cresidues thatare positively charged and make up the CPY -binding sites (Fig. 4A,B), the basic residues in the vicinity ... affinity for phospholipid membranes,to obtain additional information on the involvement of the CPY -binding sites of I Cin its phospholipid recogni-tion, we determined the membrane -binding parametersfor...
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Tài liệu Báo cáo khoa học: Liver X receptor agonists inhibit tissue factor expression in macrophages docx
... leastin part through inhibition of the NFjB signaling pathway. In addition,in vivo, LXR agonists reduced TF expression within aortic lesions in anatherosclerosis mouse model as well as in kidney ... preventfunctional activation of NFjB. Several models mightexplain the inhibitory effect of LXR agonists on func-tional NFjB activity. It is known that transcriptionalactivation by nuclear receptors involves ... gene expression in vivo, we first inves-tigated the effect of administration of LXR agonists on induction of TF expression by LPS stimulation inC57Bl ⁄ 6 mice. LPS at 4 mgÆkg)1induced TF mRNA3.5-fold...
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Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx
... replication mechanism of the hepatitis C virus (HCV), we have studied the role of sequences at the 3¢-end of HCV minus-strand RNA in the initiation of synthesis of the viral genome by viral RNA -dependent ... though it is about 25%that of the wild -type (–)IRES. However in the lattercase the synthesis is less processive as a pause is observed in about half of the initiation events. Theseresults indicate ... 16- fold higher than that of wild -type RNA, respectively. The strong effect of the deletion of nt 219–239 on RNA binding correlated with the effect of this deletion on RNA synthesis, suggesting...
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Tài liệu Báo cáo khoa học: "TYPE-RAISING AND DIRECTIONALITY IN COMBINATORY GRAMMAR*" pdf
... in the crucial position in ( 26) , unrelated to the positional condi- tion DP~r9 on the argument of the predicate itself, to define the distinguished position of the predicate argument of the ... like (15) are still allowed Coecause of the non-identity noted in the discussion of (18) between the distinguished posi- tion of arguments of functions and the position of the function itself). ... distinct posi- tions - that is, that Y not be coerced to the empty string. This condition is implicit in the Principle of Adjacency (see above), although in the notation of 3 Declaritivising...
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