Báo cáo khoa học: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand pdf

... Asn73 of BMP -6 in the wrist epitope is crucial for recognition by the activin receptor type I. In the absence of the carbohydrate moiety, activin receptor type I- mediated signaling of BMP -6 is totally ... totally diminished. Thus, flexibility within the binding epitope of BMP -6 and an unusual recognition motif, i. e. an N-glycosylation motif, possibl...

Ngày tải lên: 23/03/2014, 07:20

... in that they do not appear to contain a signal sequence or pro-sequences [6 8]. Surprisingly, the amino acid composition of proteins purified from Atlantic snailfish skin tissue is quite sim- ilar ... snailfish contradicts the A B C D Fig. 4. Distribution of type I AFP mRNA in skin and liver tissues from Atlantic and dusky snailfish. (A) Northern blot analysis of skin tissue RNA...

Ngày tải lên: 20/02/2014, 02:22

... organism to adapt to its fluctuating nutri- tional status or to varying environmental conditions. However, the identification of the key factors of mito- chondrial biogenesis in the context of proliferating cells ... oxygen consumption following the inhibition of ERRa confirmed the effect of this factor on the mitochondrial respiratory chain. Inhibition of both members...

Ngày tải lên: 06/03/2014, 09:22

... of con- ventional mononuclear cis-diamminedichloroplatinum(II) (cisplatin). These examinations took into account the fact that the local conformation of the DNA at the sites of the contacts of ... this additional protection in the duplex 1,4-IEC in the 5¢)5¢ direction is more extensive (Fig. 6) . The latter additional protection is observed for two sites on the...

Ngày tải lên: 23/03/2014, 10:21

... G (1991) The purification of tissue inhibitor of metallo- proteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 ... know the role of individual MMPs, their expression pattern and activation mechanisms. The best-described activation mechanism for MMP-2 is the two-step cell-surface ac...

Ngày tải lên: 18/02/2014, 11:20

... mediated via two distinct sig- naling pathways. The first is enhanced Ca 2+ mobilization by the inositol 1,4,5-trisphosphate receptors due to inhibition of protein kinase A. The second pathway concerns ... PI3-Kc specific inhibitor, AS252424, antagonized the P2Y 12 - dependent part of the Ca 2+ response, indicating that PI3-Kß is the main isoform in Ca 2+ signal modulati...

Ngày tải lên: 18/02/2014, 16:20

... CPY -binding sites participates in regulation of the specific binding of I C to the anionic phospholipid membranes (Fig. 4A). The participation of the N-terminal region of bovine PEBP in its mem- brane ... mutational studies on the membrane binding of I C and the disposition of the I C residues that are positively charged and make up the CPY -binding s...

Ngày tải lên: 19/02/2014, 05:20

... least in part through inhibition of the NFjB signaling pathway. In addition, in vivo, LXR agonists reduced TF expression within aortic lesions in an atherosclerosis mouse model as well as in kidney ... prevent functional activation of NFjB. Several models might explain the inhibitory effect of LXR agonists on func- tional NFjB activity. It is known that transcriptional activatio...

Ngày tải lên: 19/02/2014, 17:20

... replication mechanism of the hepatitis C virus (HCV), we have studied the role of sequences at the 3¢-end of HCV minus-strand RNA in the initiation of synthesis of the viral genome by viral RNA -dependent ... though it is about 25% that of the wild -type (–)IRES. However in the latter case the synthesis is less processive as a pause is observed in about hal...

Ngày tải lên: 20/02/2014, 01:20

... in the crucial position in ( 26) , unrelated to the positional condi- tion DP~r9 on the argument of the predicate itself, to define the distinguished position of the predicate argument of the ... like (15) are still allowed Coecause of the non-identity noted in the discussion of (18) between the distinguished posi- tion of arguments of functions and...

Ngày tải lên: 20/02/2014, 21:20