Báo cáo khoa học: Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe–S proteins pot

... and significant progressive loss of mitochondrial Fe–S pro- teins with no substantial change in their mRNA level. The correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe–S ... Upregulation of mitochondrial proteases in FRDA FEBS Journal 276 (2009) 1036–1047 ª 2009 The Authors Journal compilation ª 2009 FEBS 1047 Frataxin deficiency...

Ngày tải lên: 23/03/2014, 06:20

... exhibits both hyperphagia and severe features of type 2 diabetes. Both the KK and KK-A y strains are useful for study- ing therapies for the prevention of diabetes and obes- ity. We thus crossed ... Expression of RMI1 in normal (5 weeks of age) and obese (15 weeks of age) KK-A y mice (n = 6 per group). Sub, subcutaneous; Abd, intra- abdominal. (C) Expression of RMI1 in t...

Ngày tải lên: 16/02/2014, 09:20

... important adaptation mechanism of all muscle types to increased demands of energy as a result of extensive work and chronic exercise [8]. The mechanism of control of mitochondrial biogenesis in muscles ... fibers display a large degree of plasti- city [7,26], including rearrangement of gene expression of myofibrillar and other protein isoforms (such as mitochondrial pro...

Ngày tải lên: 19/02/2014, 07:20

... were a result of basal [Ca 2+ ] i dif- ferences among cell types. In both R42P and G328E cells, the effects of carbachol on [Ca 2+ ] i lasted for a longer time, and a long tail-off effect was ... degradation of misfolded proteins derived from the endoplasmic reticulum (ER) [10,11]. The ER plays a pivotal role in the processing and folding of proteins, as well as in the regula...

Ngày tải lên: 16/03/2014, 03:20

... in the level of Lon protein from the mitochondrial matrix of 10-month- and 27-month-old rats, as shown by Western blot analysis (Fig. 2B,C). Fig. 1. Assessment of the purity of mitochondrial ... intense signals of 70 and 50 kDa, while the bands at 60 and 150 kDa vanished. With oxyblot (Fig. 4C), antibodies stained carbonylated proteins mainly in band ranges of 30–60...

Ngày tải lên: 20/02/2014, 11:20

... BÁO CÁO KHOA HỌC CHUYÊN ĐỀ SỞ HŨU CHUNG HỢP NHẤT TRONG QUAN HỆ HÔN NHÂN THEO QUY ĐỊNH CỦA LUẬT HÔN ... điều 27 luật HNGĐ 2000 Điểm 3b Nghị quyết 02-2000 của HĐTP TAND tối cao cũng mang ý nghĩa tương tự Trích Nghị quyết 02-2000 của HĐTP TAND tối cao: 3. Tài sản chung của vợ chồng (Đìêu 27). a. Khoản ... : không có - thu nhập khác trong thời kỳ hôn nhân ( hướng dẫn tại điểm 3a NQ 02-2000 của...

Ngày tải lên: 10/04/2013, 11:57

... minh, hp eiing phii nghien eiiu cdng chiing nhu viee nghien ciiu thi trubng cua nganh khoa hpc marketing trong kinh te. Vai trb ciia cdng chiing dan ed vai trb tich cue nguge ... cdng chiing nhd den ciing cho thay mdi quan he giua edng ehiing va van nghe si cbn nhilu long leo. Cd 31 ngdi sao ea nhac dugc edng ehiing nhac den, trong dd ehi ed 12 nhac si,...

Ngày tải lên: 18/02/2014, 03:20

... at the level of the portal area, as expected in response to the protrusion of the glycine moieties, and at the level of strand F, strand H and strand I, in close contact with the ligand bound at ... combination of those of the free ligand and the protein. Diffusion experiments were performed on wild-type and T91C L-BABP complexed with GCDA and GCA at protein ⁄ ligand ratio...

Ngày tải lên: 18/02/2014, 06:20

... Khoa hoc Gido due- Ngh VAN DE QUAN U CHAT LUtfNG QUA TRINH DAY HOC Of CAC TRITONG DAI HOC NGOAI NGUf • TUS. NGUYEN ... cac chua'n mdc se phat hien ddoc 46 KHGD so 57, thdng 6 - 2010 nf T—ft Nghien cdu Khoa hoc Gido due loi xay ra trong qua trinh thdc hien nham dam bao va nang cao chat luong ... quan trong trong vai trd cau ndi bdi le con dddng...

Ngày tải lên: 06/03/2014, 22:20

Ngày tải lên: 06/03/2014, 22:21