Báo cáo khoa học: Investigation of leucine-rich repeat kinase 2 Enzymological properties and novel assays pptx
Báo cáo khoa học: Investigation of leucine-rich repeat kinase 2 Enzymological properties and novel assays pptx
... IC
50
(nM) G2019S IC
50
(nM)
JAK3 inhibitor VI 22 ± 2. 5 40 ± 4
K252A 3.6 ± 0 .2 2.8 ± 0.1
Staurosporine 2. 0 ± 0.1 1.8 ± 0.09
Su-1 124 8 15 ± 1.3 26 ± 1.7
Ro-31- 822 0 26 71 ± 895 1 922 ± 665
V. S. Anand et ... (pmol·min
–1
·µg
–1
)
–1 2
0 1 3 4 5
0.0
0 .2
0.4
0.6
0.8
1.0
1 .2
[D1994A]
[WT]
[G2019S]
[I2 020 T]
[I1 122 V]
[R1441C]
[Y1699C]
WT
G2019S D1994A R1441C Y1...
Báo cáo khoa học: Investigation of the contribution of histidine 119 to the conduction of protons through human Nox2 pptx
... UK, 20 03.
(Received 1 6 July 20 04, accepted 20 August 20 04)
Eur. J. Biochem. 27 1, 4 026 –4033 (20 04) Ó FEBS 20 04 doi:10.1111/j.14 32- 1033 .20 04.04340.x
whether introduced into the full-length Nox2 ... cPLA
2
for both the
activation of superoxide generation [26 ] and the gating of
the proton channel [27 ,28 ] can be over come by the addition
of arachidonate acid. The si...
Báo cáo khoa học: Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor f chain by the protein tyrosine kinase Lck potx
... No.
1N 2. 3 ± 0.1 28 .0 ± 3.0 121 .8 2
1C 3.1 ± 0 .2 2.3 ± 0.7 7.4 2
2N 3.9 ± 1.6 7.8 ± 3.0 20 .0 3
2C 21 .7 ± 2. 0 3.8 ± 0.8 1.8 2
3N 9 .2 ± 0.4 95.0 ± 6.8 103.8 2
3C 11.9 ± 1.8 98.4 ± 16.8 82. 7 3
23 72 H. ... TCRf;PTK,protein
tyrosine kinase; SH2, src homology domain 2; TCR, T-cell receptor.
(Received 18 February 20 03, revised 29 March 20 03,
accepted 2 April 20 0...
Báo cáo khoa học: Investigation of the substrate specificity of a b-glycosidase from Spodoptera frugiperda using site-directed mutagenesis and bioenergetics analysis pdf
... (EC 3 .2. 1 .21 ) GenBank access no.: A F0 527 29.
(Received 2 8 March 20 04, revised 24 August 20 04,
accepted 3 September 20 04)
Eur. J. Biochem. 27 1, 4169–4177 (20 04) Ó FEBS 20 04 doi:10.1111/j.14 32- 1033 .20 04.04354.x
Agrobacterium ... 0.68 0. 027
E451A
a
0.0000 82 3.1 0.000 026 0.00 028 5 0.50 0.00057 0.00061 1.53 0.0039
Q39E 0.051 1.61 0.0 321 0.0377 2. 8 0.0134 1.49 2....
![Báo cáo khoa học: Investigation of the interaction between the atypical agonist c[YpwFG] and MOR docx](https://media.store123doc.com/images/document/14/rc/ht/medium_57MlXT7HZ5.jpg)
Báo cáo khoa học: Investigation of the interaction between the atypical agonist c[YpwFG] and MOR docx
... ligand are those corresponding to
Tyr148, Met151 and Phe1 52 (TMH III), Lys233 and
Phe237 (TMH V), Ile296, Val300, Lys303 and Thr307
(TMH VI), Trp318 and Ile 322 (TMH VII) and
Thr218, Leu219 and ... within 5 A
˚
of com-
pound 3, one between O
c1
of Thr218 (EL -2) and the
backbone oxygen of Phe4 (2. 94 A
˚
), and one between
the hydroxyl oxygen of the Tyr1 group and...
Báo cáo khoa học: Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism pptx
... June 20 06, revised 21 Septem-
ber 20 06, accepted 22 September 20 06)
doi:10.1111/j.17 42- 4658 .20 06.05513.x
Prolonged exposure of pancreatic beta cells to the sulfonylureas glibenca-
mide and tolbutamide ... decarboxylation
of pyruvate in pancreatic islets. Metabolism 42, 122 9–
123 1.
18 Khan A, Ling ZC & Landau BR (1996) Quantifying the
carboxylation of pyruvate in pan...
Tài liệu Báo cáo khoa học: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases pptx
... in regulation of src family kinases. J Biol
Chem 26 6, 24 249 24 2 52.
23 Blake RA, Broome MA, Liu X, Wu J, Gishizky M,
Sun L & Courtneidge SA (20 00) SU6656, a selective src
family kinase inhibitor, ... Institute of
Cancer Research, Haddow Laboratories, 15
Cotswold Road, Sutton, Surrey SM2 5NG,
UK
Fax: +44 020 8 722 4 126
Tel: +44 020 8 722 43 52
E-mail: michelle.garrett@icr.a...
Tài liệu Báo cáo khoa học: Dimers of light-harvesting complex 2 from Rhodobacter sphaeroides characterized in reconstituted 2D crystals with atomic force microscopy docx
... the
11.4
10.8
12. 8 7.0
6.0
12. 9 7.0
7.0
7.15.3
10.9
Strongly protruding LH2 (up) Weakly protruding LH2 (down)
12. 0
15.0
22 000
F
A
B
C
D
E
20 000
21 000
18 367
ABCDE
21 20 8 21 22 4
20 408
19 047
19 ... dialysis [26 ].
On the basis of AFM imaging of both the periplasmic
and cytoplasmic sides of LH2’s after reconstitution,
ellipticity and tilt of the LH2’s have been r...
Tài liệu Báo cáo khoa học: Role of receptor-mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity pdf
... D
FEBS Journal 27 4 (20 07) 26 14 26 29 ª 20 07 The Authors Journal compilation ª 20 07 FEBS 26 27
protein of the rat liver after partial hepatectomy. Bio-
chim Biophys Acta 122 2, 81–87.
24 Wedegaertner ... action of cholera toxin and cathepsin D T. El Hage et al.
26 20 FEBS Journal 27 4 (20 07) 26 14 26 29 ª 20 07 The Authors Journal compilation ª 20 07 FEBS
Assessment of...
Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... mg, 82% ), m.p. 22 0 22 3 °C, lit.
21 6 21 8 °C [37].
1
H NMR (dimethylsulfoxide-d
6
) d: 8. 72 (s,
1H, 2- H), 8 .20 (d, J ¼ 2 Hz, 1H, 4-H), 7.65 (d, J ¼ 2 Hz,
1H, 6-H), 5.81–6. 12 (br, 3H, NH, NH
2
) ... concentrations of 11 l
M (·), 22 lM (m), 67 lM (d) and 22 4 lM (j).
Methionine synthase inhibitors E. C. Banks et al.
29 0 FEBS Journal 27 4 (20 07) 28 7 29 9 ª 20 06 Th...