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Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot

Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot

Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot

... E-cadherinor other protein(s) in the hDlg complex under stressfulconditions, and the cortical cytoskeleton is thereforedisrupted and hDlg released into the cytoplasm. The lack of effect of an hDlg ... regulation of early apoptotic events.DiscussionOur aim was to gain a better understanding of the role of hDlg phosphorylation in the adaptation of cells to stress, by determining whether stress ... activation of caspases causes the proteolysis of hDlg at YEVD747 and this releases it from the cortical cytoskeleton at the membrane into the cytoplasm where hDlg may befurther proteolysed. In immunolocalization...
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Báo cáo khoa học: Residues near the N-terminus of protein B control autocatalytic proteolysis and the activity of soluble methane mono-oxygenase doc

Báo cáo khoa học: Residues near the N-terminus of protein B control autocatalytic proteolysis and the activity of soluble methane mono-oxygenase doc

... reaction is independent of the presence of contaminating proteins and so is almostcertainly autocatalytic. The insensitivity of the position o f cleavage to the amino-acid sequence a round the c ... rate of autoproteolysis of protein B, in response to environ-mental factors or the metabolic state of the cell. It is interesting to note that the protein B of Ms. trichosporiumOB3b is much less ... implies t he involve-ment of other parts of the structure in determining the sensitivity of the scissile peptide bond to cleavage. Intrinsicnucleophilic activity within protein B is consistent with...
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Tài liệu Báo cáo khoa học: Proteolysis of Pseudomonas exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying in vitro ADP-ribosylating and apoptotic effects doc

Tài liệu Báo cáo khoa học: Proteolysis of Pseudomonas exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying in vitro ADP-ribosylating and apoptotic effects doc

... membrane and into the cytoplasm.This is initiated by cell surface binding of ETA to the a2MG ⁄ LRP1 receptor [4], which is followed by internalization of the toxin–receptor complex to the endosomal ... hand, and the mitochondrialmembrane on the other hand. However, the potentialrole (if any) of ADP-ribosylation of EF-2 in the mitochondrial apoptotic response induced by the toxin remains to ... it is the ETA–ETA receptor complex that is internalized into toxin-treated cells, there are no published reports on the fate of the ETA receptor during toxin endocytosis. To determine whether...
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Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf

Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf

... addition of ISP and Qcr10p).On the other hand, in the transition from the 500 kDaband to the 670 kDa band, a structural rearrangement of the bc1complex may occur due to the binding of ISP and ... for the insertion of ISP into an immature bc1complex and that the association of the Qcr9p subunitwith the bc1complex precedes the binding of ISP. In fact, the direct absence of ISP (DISP), ... respiratory chain, the assistance of specificchaperone proteins is also required. The available dataindicate that the accessory factor Bcs1p is involved in the binding of ISP to an immature bc1intermediate[28,29]...
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Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt

Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt

... the basic feature discriminating the 4F2hcproteins from both rBATs and GH13 enzymes is the lack of domain B protruding out of the TIM barrel in the place of loop 3 connecting the b3-strand to ... proteins. In allother groups, this domain is more or less distorted,culminating in complete loss in 4F2hc proteins. The presence of full GH13 domain B in hcHAT1 and the absence of its parts in ... barrel domain,including domain B and the C-terminal domain C forrBAT proteins (669 residues on average); (b) the cata-lytic TIM barrel domain, including domain B and the C-terminal domain C for...
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Tài liệu Báo cáo khoa học: Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide doc

Tài liệu Báo cáo khoa học: Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide doc

... with the PRAD domain of ColQ indicates that the WAT domain of the C. intestinalis AChE is capable of organizing the sub-units into a tetramer through interaction with the PRAD domain of ColQ. The ... fromC. intestinalis expressed in vitro and nativeenzyme expressed in vivo indicates the enzyme is AChE To determine the nature of the cholinesterase activity of the recombinant C. intestinalis enzyme ... vertebrate AChEs is missing in C. intestinalisAChE, Tyr70, a member of the peripheral site, which is replaced by Ile97. The Kss of C. intestinalis AChEfor ATCh is rather high and this substitution...
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Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt

Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt

... counterion. In contrast to the stabilizing effects of salts according to the Hofmeister series, the chloride salt is less destabilizingthan the acetate salt. As discussed above, the inactiva-tion by ... of PLDa2 by calcium ions is due to the binding of cal-cium ions to the enzyme, and not (or not only) to bet-ter structuring of the substrate aggregates.From both the CD and the activity data, two ... packing of the aromatic residues in the core of the protein. From the near-UV CD signals and activity data as a function of the calcium ion concentration, two bind-ing events characterized by dissociation...
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Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf

Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf

... after 48 h of incubation in the two celllines (Fig. 2A). Likewise, hypoxia decreased the levels of HO-1 and HO-2 proteins by more than 60% and 30%, respectively, in HeLa cells, and by 90% and 20%, ... of HO-1 and HO-2 mRNA in YN-1 cells To explore the mechanism of the hypoxia -mediated reduction of HO-1 and HO-2 protein levels, we ana-lyzed the effects of hypoxia on the expression of HO-1 and ... respect to the intensity for the a-tubulin signal. Shown are the relativeexpression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and those of HO-2 protein in K562 cells (D). The intensity...
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Tài liệu Báo cáo khoa học: Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina doc

Tài liệu Báo cáo khoa học: Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina doc

... The GLD1 pro-tein was tagged with a histidine tag at the N-terminalend by adding the coding sequence for six histidines to the end of the open reading frame, and then expressed in S. cerevisiae. ... glycerol and NADP in the oxidizing direction and activities withDHA or d-glyceraldehyde and NADPH in the redu-cing direction. According to the International Union of Biochemistry and Molecular ... from the pYX212 [17], and the orientation of the open reading frame in the expression vector was checked. The S. cerevisiaestrain CEN.PK2-1B was then transformed with the expres-sion vector and...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc

Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc

... 20–564), and the model is composed of residues 25–540. The overall structure of the model of IPU and the mutated residues in this study areshown in Fig. 3. To elucidate the mechanism of the substrate ... 372, and 373are the potential catalytic r esidues of I PU. Also, Trp425 of Dex49A, which is the corresponding residue of Trp402 of IPU, is reportedly located in the vicinity of the active site and ... vulgaris, TVA II (PDB ID, 1BVZ;Z score of 3.2) [45] was a solution in the Dali result. It is likely that the inte rface between N-terminal and b-he licaldomains participate in binding of the...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDETrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM