Báo cáo khoa học: Deletion of Phe508 in the ﬁrst nucleotide-

Báo cáo khoa học: Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone docx

... (2009) 709 7–7109 ª 2009 The Authors Journal compilation ª 2009 FEBS 7109 Deletion of Phe508 in the ﬁrst nucleotide-binding domain of the cystic ﬁbrosis transmembrane conductance regulator increases ... & Thomas PJ (1997) The molecular chaperone Hsc70 assists the in vitro folding of the N-terminal nucleotide-binding domain of the...

Ngày tải lên : 23/03/2014, 05:22

13
393
0

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... locations of the missense mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinase domain. The mutated residues are indicated in yellow, ... the linker B kinase region of SYK. The PH domain of TFKs usually binds to phosphatidylino- sitol-3,4,5-trisphosphate, thereby bringing them in close proximity to o...

Ngày tải lên : 14/02/2014, 18:20

10
926
0

Tài liệu Báo cáo khoa học: "Liars and Saviors in a Sentiment Annotated Corpus of Comments to Political debates" pdf

... definite descrip- tions and nicknames. 1 Introduction Most of the existing approaches to opinion mining propose algorithms that are independent of the text genre, the topic and the target involved. ... Also interesting is the information contained in the distributions of positive opinions. that there is a large correlation ( The Pearson corr lation coefficient is r...

Ngày tải lên : 20/02/2014, 05:20

5
499
0

Báo cáo khoa học: Polysaccharide binding sites in hyaluronate lyase – crystal structures of native phage–encoded hyaluronate lyase and its complexes with ascorbic acid and lactose docx

... speciﬁc for the binding because of the unique positions of LysC179 and GluB167 and the scope of conformational changes of their side chains (Fig. 2A). On moving further from the N-terminus and ... nature of the binding of ascorbic acid to proteins. Although ascorbic acid is a small molecule, it blocks the most attractive binding subsites in the protein, leading t...

Ngày tải lên : 23/03/2014, 04:21

11
517
0

Báo cáo khoa học: A single mutation in Escherichia coli ribonuclease II inactivates the enzyme without affecting RNA binding pot

... representation of the structure of RNase II. Three different domains can be proposed for RNase II: the N-terminal cold shock domain (CSD), the central RNB domain (RNB), and the C-terminal S1 domain (S1). The ... another acidic residue in the vicinity, allowing the metal binding even in the absence of these residues. This normally results in a decrease in...

Ngày tải lên : 30/03/2014, 15:20

12
320
0

Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc

... thetase to esterify the 13cROL generated in the reaction. Therefore, 13cROL is accumulated in the absence of LRAT in the reaction (Fig. S3B). Under the in vitro assay conditions of the ... RPE65c in the inner retina, including Mu ¨ ller cells, but not in the RPE. Furthermore, double-immuno- staining of dissociated retinal cells using antibodies for RPE65c...

Ngày tải lên : 14/02/2014, 14:20

14
753
0

Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

... integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling. Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... outcome. This minireview summarizes recent progress in the understanding of how osmosensing and osmosignaling integrate into the overall context of growth factor signaling and the...

Ngày tải lên : 18/02/2014, 16:20

5
792
0

Tài liệu Báo cáo khoa học: An intermediate step in the evolution of ATPases – a hybrid F0–V0 rotor in a bacterial Na+ F1F0 ATP synthase pdf

... of the ion-binding site. Therefore, the c ring of A. woodii has only 10 membrane-buried negative charges that are essential for binding the ion and also for the rotational mechanism of the ring. ... to the other two, forming the same pattern as in the AFM surface representation of Fig. 2A. By comparison with the 3D structure of the I. tartaricus c ring [24]...

Ngày tải lên : 18/02/2014, 17:20

9
773
0

Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebraﬁsh pptx

... Follistatin, Chordin and Noggin [12]. These proteins are antagonists of BMP and other members of the TGF-b family, binding to and inhibit- ing these signaling molecules from binding to their receptors ... with a single transmembrane domain. Bind- ing of the ligand to the receptor complex induces the type II receptor to phosphorylate the type I receptor, which then leads to...

Ngày tải lên : 19/02/2014, 00:20

8
845
0

Tài liệu Báo cáo khoa học: Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae docx

... most of the protein components are integral in the membrane, most of these mitochondrial proteins behave as if they have a-helical transmembrane domains, rather than b-barrels. These proteins ... membrane protein with its N-terminal FAD-binding domain facing the intermembrane space. This topology would enable Gut2 to transfer of electrons to Nde1 in the intermembrane...

Ngày tải lên : 19/02/2014, 07:20

9
554
0