... and the induction of genes for transcription. For exampe, FAS gene is known to berepressed by DNA methylation, for which a signal is transduced by H-Ras (Fig. 3A) and radiation can induce FAS ... TNFRI.High expression of FADD in mammalian cells inducesapoptosis, which can be blocked by Crma, a Pox-virusgene product that also blocks FAS-induced apoptosis[115,116].The FAS protein shows ... induced. The interactionbetween FAS and FASL induces cell death that occursin a cell-autonomous manner, similar to the classicapoptotic sequence [117,118]. FAS activates caspase 3by inducing...