Báo cáo khoa học: Nuclear factor TDP-43 can affect selected microRNA levels pptx

... authors. E. Buratti et al. TDP-43 and miRNA regulation FEBS Journal 277 (2010) 2268–2281 ª ICGEB. Journal compilation ª 2010 FEBS 2281 Nuclear factor TDP-43 can affect selected microRNA levels Emanuele ... may be controlled by TDP-43. At least for TDP-43, we decided to measure the pre-miRNA levels in TDP-43- depleted and mock-depleted cells. For this reason, we measured...

Ngày tải lên: 22/03/2014, 21:21

... the nuclear factor- jB (NF-jB) subunits p65 ⁄ RELA and p50 ⁄ NFjB1, and also through modulation by tumor necrosis factor a. Transcriptional up-regulation of Rnf33 by NF-jB and tumor necrosis factor- a ... transcriptional activity of differentially phosphorylated nuclear factor- kappa B. J Biol Chem 280, 244–252. 31 Lysiak JJ (2004) The role of tumor necrosis factor- alpha and inte...

Ngày tải lên: 29/03/2014, 00:20

... method. Asterisks indicate statistically significant differ- ences at ****P £ 0.0005; ***P £ 0.005; **P £ 0.05; *P £ 0.1 levels. J. Cruz et al. Nuclear receptors in Aedes aegypti FEBS Journal ... Cho WL, Taylor DG, Leff T & Raikhel AS (1998) Three iso- forms of a hepatocyte nuclear factor- 4 transcription factor with tissue- and stage-specific expression in the adult mosquito. J Bi...

Ngày tải lên: 18/02/2014, 13:20

... necessary for the inhibition of the factor VIIa–tissue factor complex, which forms a ter- tiary complex with factor Xa, whereas the second Kunitz domain inhibits factor Xa. TFPI also inhibits a variety ... T, Nagasaka T, Ohsumi K & Saito H (1996) Human ryu- docan from endothelium-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhi- bitor. J B...

Ngày tải lên: 19/02/2014, 00:20

... potent angiogenic factors, in cluding fibroblast growth factors (FGFs), platelet-derived growth factor B (PDGF-B) and vascular endothelial growth factor (VEGF) [1,2]. These factors are counterbalanced ... endostatin, thrombospondin, and platelet factor- 4 [3–8]. Platelet factor- 4 (PF-4), a member of the CXC chemo- kine family [9], inhibits fibroblast growth factor- 2 (FGF2)- induced pro...

Ngày tải lên: 19/02/2014, 16:20

... of nuclear pro- tein complexes. Nuclear actin plays a role in many nuclear functions [6–8]. First, nuclear actin is required for transcription by all three nuclear RNA polymerases. Second, nuclear ... myocardin-related transcription factor; NLS, nuclear localization signals; NM1, nuclear myosin 1; PBX1, pre-B-cell leukemia transcription factor 1; PCAF, p300 ⁄ CREB binding p...

Ngày tải lên: 07/03/2014, 01:20

... PrP c levels decreased at the 18 and 24 h time points. Similar to the cell lines, PrP c expression levels of BMDMs were analysed at 0 and 12 h after stimulation (bottom panel). A significant increase ... occurs in the spleen. It has been shown that various dendritic cell subsets can degrade PrP Sc [23–25] and, also, can transport PrP Sc , but their importance for neuroinva- sion is sti...

Ngày tải lên: 07/03/2014, 05:20

... spermidine levels in SMO1 and SMO5 cells. These changes in spermine and spermidine levels in both SMO1 and SMO5 overexpressing cell lines were statistically significant compared to those levels in ... mechanisms of polyamine analogs in cancer cells. Anticancer Drugs 16, 229–241. 10 Kingsnorth AN, Wallace HM, Bundred NJ & Dixon JM (1984) Polyamines in breast cancer. Br J Surg 71, 352–...

Ngày tải lên: 07/03/2014, 05:20

... of the pa nels. Ó FEBS 2004 Role of trigger factor in Tat-mediated export (Eur. J. Biochem. 271) 4783 suggesting SufI export i s not significantly affected. TF has been shown to o verlap with ... (reviewed in [2]). Recently, the cytosolic chaperone and folding catalyst trigger factor (TF) was shown to have a significant impact on the efficiency of Sec-mediated transport. Inactivation of the...

Ngày tải lên: 07/03/2014, 16:20

... this group did not demonstrate significant differences compared to the wild-type–wild-type interaction (see Table S1). As pre- viously shown (Fig. 5), a significant fraction of both the wild-type ... comple- ment factor 5a receptors trapped in the endoplasmic reticulum with brefel- din A. These results suggest that the chimeric receptors were properly folded; moreover, native complement fact...

Ngày tải lên: 23/03/2014, 04:21